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David M Cachia MD

TitleAssociate Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionHematology Oncology

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    University of Malta Medical School, Qroqq, , MaltaMD

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Das A, Gunasekaran A, Stephens HR, Mark J, Lindhorst SM, Cachia D, Patel SJ, Frankel BM. Establishing a Standardized Method for the Effective Intraoperative Collection and Biological Preservation of Brain Tumor Tissue Samples Using a Novel Tissue Preservation System: A Pilot Study. World Neurosurg. 2022 May; 161:e61-e74. PMID: 35032716.
      Citations:    Fields:    Translation:Humans
    2. Martínez Santos JL, Suarez-Meade P, Cachia D, Lindhorst SM, Das A. Current Use and Limitations of Cultured High-Grade Meningioma Cells in Neuro-Oncological Research - In Response to: "Caution Using Meningioma Cell Lines as Tumor Models". Cancer Invest. 2022 02; 40(2):132-133. PMID: 34620006.
      Citations:    Fields:    Translation:HumansCells
    3. Ajinkya S, Fox J, Houston P, Greenblatt A, Lekoubou A, Lindhorst S, Cachia D, Olar A, Kutluay E. Seizures in Patients With Metastatic Brain Tumors: Prevalence, Clinical Characteristics, and Features on EEG. J Clin Neurophysiol. 2021 Mar 01; 38(2):143-148. PMID: 31856045.
      Citations: 1     Fields:    Translation:Humans
    4. Frankel BM, Cachia D, Patel SJ, Das A. Analysis of the P53N a Novel Protein Encoded on Chromosome 22q12.1-12.3 in Glioblastomas and Ependymomas Specimens. J Mol Neurosci. 2021 Aug; 71(8):1714-1722. PMID: 33595778.
      Citations:    Fields:    Translation:HumansCells
    5. Alshareef MA, Klapthor G, Lowe SR, Barley J, Cachia D, Frankel BM. Strategies for posterior-only minimally invasive surgery in thoracolumbar metastatic epidural spinal cord compression. Surg Neurol Int. 2020; 11:462. PMID: 33408947.
    6. Cloughesy TF, Petrecca K, Walbert T, Butowski N, Salacz M, Perry J, Damek D, Bota D, Bettegowda C, Zhu JJ, Iwamoto F, Placantonakis D, Kim L, Elder B, Kaptain G, Cachia D, Moshel Y, Brem S, Piccioni D, Landolfi J, Chen CC, Gruber H, Rao AR, Hogan D, Accomando W, Ostertag D, Montellano TT, Kheoh T, Kabbinavar F, Vogelbaum MA. Effect of Vocimagene Amiretrorepvec in Combination With Flucytosine vs Standard of Care on Survival Following Tumor Resection in Patients With Recurrent High-Grade Glioma: A Randomized Clinical Trial. JAMA Oncol. 2020 12 01; 6(12):1939-1946. PMID: 33119048.
      Citations: 34     Fields:    Translation:Humans
    7. Das A, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. Preconditioning with INC280 and LDK378 drugs sensitizes MGMT-unmethylated glioblastoma to temozolomide: Pre-clinical assessment. J Neurol Sci. 2020 Nov 15; 418:117102. PMID: 32866816.
      Citations: 2     Fields:    Translation:HumansCells
    8. Das A, Henderson FC, Alshareef M, Porto GBF, Kanginakudru I, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. MGMT-inhibitor in combination with TGF-?RI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells. Clin Transl Oncol. 2021 Mar; 23(3):612-619. PMID: 32710211.
      Citations:    Fields:    Translation:HumansCells
    9. Das A, Martinez Santos JL, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells. Cancer Invest. 2020 Jul; 38(6):349-355. PMID: 32441531.
      Citations: 5     Fields:    Translation:HumansCells
    10. Frankel BM, Cachia D, Patel SJ, Das A. Targeting Subventricular Zone Progenitor Cells with Intraventricular Liposomal Encapsulated Cytarabine in Patients with Secondary Glioblastoma : A Report of Two Cases. SN Compr Clin Med. 2020 Jun; 2(6):836-843. PMID: 32704621.
    11. Nam JY, Gilbert A, Cachia D, Mandel J, Fuller GN, Penas-Prado M, de Groot J, Kamiya-Matsuoka C. Pineal parenchymal tumor of intermediate differentiation: a single-institution experience. Neurooncol Pract. 2020 Dec; 7(6):613-619. PMID: 33312675.
    12. Frankel BM, Cachia D, Patel SJ, Das A. Analysis of P78: A Novel Cytoplasmic Membrane-Associated Protein Encoded on Chromosome 19q13.3 in Glioma Specimens. J Mol Neurosci. 2020 Sep; 70(9):1415-1424. PMID: 32367506.
      Citations:    Fields:    Translation:HumansCells
    13. Das A, Alshareef M, Martinez Santos JL, Porto GBF, McDonald DG, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. Evaluating anti-tumor activity of palbociclib plus radiation in anaplastic and radiation-induced meningiomas: pre-clinical investigations. Clin Transl Oncol. 2020 Nov; 22(11):2017-2025. PMID: 32253706.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    14. Das A, Alshareef M, Henderson F, Martinez Santos JL, Vandergrift WA, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D. Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth. Clin Transl Oncol. 2020 Jul; 22(7):1138-1145. PMID: 31732915.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    15. Fox J, Ajinkya S, Greenblatt A, Houston P, Lekoubou A, Lindhorst S, Cachia D, Olar A, Kutluay E. Clinical characteristics, EEG findings and implications of status epilepticus in patients with brain metastases. J Neurol Sci. 2019 Dec 15; 407:116538. PMID: 31644990.
      Citations:    Fields:    Translation:Humans
    16. Harrison RA, Anderson MD, Cachia D, Kamiya-Matsuoka C, Weathers SS, O'Brien BJ, Penas-Prado M, Yung WKA, Wu J, Yuan Y, de Groot JF. Clinical trial participation of patients with glioblastoma at The University of Texas MD Anderson Cancer Center. Eur J Cancer. 2019 05; 112:83-93. PMID: 30951926.
      Citations: 7     Fields:    Translation:Humans
    17. Fox J, Ajinkya S, Houston P, Lindhorst S, Cachia D, Olar A, Kutluay E. Seizures in patents with primary central nervous system lymphoma: Prevalence and associated features. J Neurol Sci. 2019 May 15; 400:34-38. PMID: 30901566.
      Citations: 3     Fields:    Translation:Humans
    18. D'Angelo F, Ceccarelli M, Garofano L, Zhang J, Frattini V, Caruso FP, Lewis G, Alfaro KD, Bauchet L, Berzero G, Cachia D, Cangiano M, Capelle L, de Groot J, DiMeco F, Ducray F, Farah W, Finocchiaro G, Goutagny S, Kamiya-Matsuoka C, Lavarino C, Loiseau H, Lorgis V, Marras CE, McCutcheon I, Nam DH, Ronchi S, Saletti V, Seizeur R, Slopis J, Suñol M, Vandenbos F, Varlet P, Vidaud D, Watts C, Tabar V, Reuss DE, Kim SK, Meyronet D, Mokhtari K, Salvador H, Bhat KP, Eoli M, Sanson M, Lasorella A, Iavarone A. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nat Med. 2019 01; 25(1):176-187. PMID: 30531922.
      Citations: 66     Fields:    Translation:HumansCells
    19. Burton C, Das A, McDonald D, Vandergrift WA, Patel SJ, Cachia D, Bartee E. Oncolytic myxoma virus synergizes with standard of care for treatment of glioblastoma multiforme. Oncolytic Virother. 2018; 7:107-116. PMID: 30538967.
    20. Das A, Henderson F, Lowe S, Wallace GC, Vandergrift WA, Lindhorst SM, Varma AK, Infinger LK, Giglio P, Banik NL, Patel SJ, Cachia D. Single agent efficacy of the HDAC inhibitor DATS in preclinical models of glioblastoma. Cancer Chemother Pharmacol. 2018 12; 82(6):945-952. PMID: 30209569.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Cachia D, Johnson DR, Kaufmann TJ, Lowe S, Andersen S, Olar A, Cooper SL, Frankel BM, Gilbert MR. Case-based review: ependymomas in adults. Neurooncol Pract. 2018 Aug; 5(3):142-153. PMID: 31386035.
    22. Mandel JJ, Yust-Katz S, Patel AJ, Cachia D, Liu D, Park M, Yuan Y, Kent TA, de Groot JF. Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma. Neuro Oncol. 2018 01 10; 20(1):113-122. PMID: 29016865.
      Citations: 20     Fields:    Translation:Humans
    23. Yust Katz S, Cachia D, Kamiya-Matsuoka C, Olar A, Theeler B, Penas Prado M, Gilbert MR, Armstrong T. Corrigendum to 'Ependymomas arising outside of the central nervous system: A case series and literature review' [J Clin Neurosci 47 (2018) 202-207]. J Clin Neurosci. 2018 05; 51:105. PMID: 29295763.
      Citations:    Fields:    
    24. Yust Katz S, Cachia D, Kamiya-Matsuoka C, Olar A, Theeler B, Penas Prado M, Gilbert MR, Armstrong T. Ependymomas arising outside of the central nervous system: A case series and literature review. J Clin Neurosci. 2018 Jan; 47:202-207. PMID: 29054328.
      Citations: 5     Fields:    Translation:Humans
    25. Cachia D, Elshafeey NA, Kamiya-Matsuoka C, Hatami M, Alfaro-Munoz KD, Mandel JJ, Colen R, DeGroot JF. Radiographic patterns of progression with associated outcomes after bevacizumab therapy in glioblastoma patients. J Neurooncol. 2017 Oct; 135(1):75-81. PMID: 28702781.
      Citations: 11     Fields:    Translation:Humans
    26. Pinnix CC, Chi L, Jabbour EJ, Milgrom SA, Smith GL, Daver N, Garg N, Cykowski MD, Fuller G, Cachia D, Kamiya-Matsuoka C, Woodman K, Dinardo C, Jain N, Kadia TM, Pemmaraju N, Ohanian M, Konopleva M, Kantarjian HM, Dabaja BS. Dorsal column myelopathy after intrathecal chemotherapy for leukemia. Am J Hematol. 2017 Feb; 92(2):155-160. PMID: 27874212.
      Citations: 1     Fields:    Translation:Humans
    27. Kamiya-Matsuoka C, Cachia D, Waguespack SG, Crane CH, Mahajan A, Brown PD, Nam JY, McCutcheon IE, Penas-Prado M. Radiotherapy with concurrent temozolomide for the management of extraneural metastases in pituitary carcinoma. Pituitary. 2016 Aug; 19(4):415-21. PMID: 27106209.
      Citations: 6     Fields:    Translation:Humans
    28. Mandel JJ, Cachia D, Liu D, Wilson C, Aldape K, Fuller G, de Groot JF. Impact of IDH1 mutation status on outcome in clinical trials for recurrent glioblastoma. J Neurooncol. 2016 08; 129(1):147-54. PMID: 27270908.
      Citations: 18     Fields:    Translation:Humans
    29. Day J, Yust-Katz S, Cachia D, Wefel J, Katz LH, Tremont I, Bulbeck H, Armstrong T, Rooney AG. Interventions for the management of fatigue in adults with a primary brain tumour. Cochrane Database Syst Rev. 2016 Apr 13; 4:CD011376. PMID: 27074263.
      Citations: 16     Fields:    Translation:Humans
    30. Strickland BA, Cachia D, Jalali A, Cykowski MD, Penas-Prado M, Langford LA, Li J, Shah K, Weinberg JS. Spinal Anaplastic Oligodendroglioma With Oligodendrogliomatosis: Molecular Markers and Management: Case Report. Neurosurgery. 2016 Mar; 78(3):E466-73. PMID: 26352098.
      Citations: 1     Fields:    Translation:Humans
    31. Das A, McDonald DG, Dixon-Mah YN, Jacqmin DJ, Samant VN, Vandergrift WA, Lindhorst SM, Cachia D, Varma AK, Vanek KN, Banik NL, Jenrette JM, Raizer JJ, Giglio P, Patel SJ. RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma. Tumour Biol. 2016 Jun; 37(6):7525-34. PMID: 26684801.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Das A, Cheng RR, Hilbert ML, Dixon-Moh YN, Decandio M, Vandergrift WA, Banik NL, Lindhorst SM, Cachia D, Varma AK, Patel SJ, Giglio P. Synergistic Effects of Crizotinib and Temozolomide in Experimental FIG-ROS1 Fusion-Positive Glioblastoma. Cancer Growth Metastasis. 2015; 8:51-60. PMID: 26648752.
    33. Alfaraj WA, Cachia D, Tummala S, Thomas SK, Manasanch EE. Severe peripheral neuropathy following carfilzomib, rituximab, and dexamethasone for initial treatment of Waldenström's macroglobulinemia. Ann Hematol. 2016 Jan; 95(2):347-8. PMID: 26432713.
      Citations: 1     Fields:    Translation:Humans
    34. Cachia D, Kamiya-Matsuoka C, Mandel JJ, Olar A, Cykowski MD, Armstrong TS, Fuller GN, Gilbert MR, De Groot JF. Primary and secondary gliosarcomas: clinical, molecular and survival characteristics. J Neurooncol. 2015 Nov; 125(2):401-10. PMID: 26354773.
      Citations: 22     Fields:    Translation:Humans
    35. Kamiya-Matsuoka C, Cachia D, Yust-Katz S, Rodriguez YA, Garciarena P, Rodarte EM, Tremont-Lukats IW. Ischemic stroke in patients with gliomas at The University of Texas-M.D. Anderson Cancer Center. J Neurooncol. 2015 Oct; 125(1):143-8. PMID: 26272599.
      Citations: 4     Fields:    Translation:Humans
    36. Cachia D, Makhija M, Smith T. Cough and confusion in an elderly man with chronic lymphocytic leukemia. J Clin Neurosci. 2015 Dec; 22(12):1963,1996. PMID: 26870858.
      Citations:    Fields:    
    37. Cachia D, Kamiya-Matsuoka C, Pinnix CC, Chi L, Kantarjian HM, Cortes JE, Daver N, Woodman K. Myelopathy following intrathecal chemotherapy in adults: a single institution experience. J Neurooncol. 2015 Apr; 122(2):391-8. PMID: 25666482.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    38. Cachia D, Wani K, Penas-Prado M, Olar A, McCutcheon IE, Benjamin RS, Armstrong TS, Gilbert MR, Aldape KD. C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma. Brain Tumor Pathol. 2015 Apr; 32(2):105-11. PMID: 25388523.
      Citations: 9     Fields:    Translation:HumansCells
    39. Cachia D, Smith T, Paydarfar D, Pomorska G. A case of early-onset rapidly progressive dementia. JAMA Neurol. 2014 Nov; 71(11):1445-9. PMID: 25265527.
      Citations: 2     Fields:    Translation:Humans
    40. Cachia D, Prado MP, Theeler B, Hamilton J, McCutcheon I, Fuller GN. Synchronous rosette-forming glioneuronal tumor and diffuse astrocytoma with molecular characterization: a case report. Clin Neuropathol. 2014 Nov-Dec; 33(6):407-11. PMID: 24986181.
      Citations: 6     Fields:    Translation:Humans
    41. Cachia D, Singh C, Tetzlaff MT, Penas-Prado M. Middle cerebral artery territory infarct due to Cryptococcus infectionstitle: an uncommon indication for cerebrospinal fluid analysis in stroke patients. Diagn Cytopathol. 2015 Aug; 43(8):632-4. PMID: 25352313.
      Citations:    Fields:    Translation:HumansAnimals
    42. Kamiya-Matsuoka C, Cachia D, Olar A, Armstrong TS, Gilbert MR. Primary brain tumors and posterior reversible encephalopathy syndrome. Neurooncol Pract. 2014 Dec; 1(4):184-190. PMID: 26034631.
    43. Mandel JJ, Yust-Katz S, Cachia D, Wu J, Liu D, de Groot JF, Yung AW, Gilbert MR. Leptomeningeal dissemination in glioblastoma; an inspection of risk factors, treatment, and outcomes at a single institution. J Neurooncol. 2014 Dec; 120(3):597-605. PMID: 25168214.
      Citations: 19     Fields:    Translation:Humans
    44. Deeb W, Cachia D, Quinn C, Salameh J. Peripheral neuropathy after hair dye exposure: a case report. J Clin Neuromuscul Dis. 2014 Jun; 15(4):161-3. PMID: 24872215.
      Citations:    Fields:    Translation:Humans
    45. Cachia D, Izzy S, Berriosmorales I, Ionete C. Drug-induced thrombocytopenia secondary to natalizumab treatment. BMJ Case Rep. 2014 May 30; 2014. PMID: 24879724.
      Citations: 2     Fields:    Translation:Humans
    46. Cachia D, Stine C. Child Neurology: cognitive delay in a 7-year-old girl. Neurology. 2013 Nov 12; 81(20):e148-50. PMID: 24218321.
      Citations: 1     Fields:    Translation:Humans
    47. Cachia D, Izzy S, Smith T, Ionete C. A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma. JAMA Neurol. 2013 Sep 01; 70(9):1192-3. PMID: 23857254.
      Citations: 2     Fields:    Translation:Humans
    48. Cachia D, Izzy S, Ionete C, Salameh J. Brachial amyotrophic diplegia in the setting of complete HIV viral load suppression. BMJ Case Rep. 2012 Dec 06; 2012. PMID: 23220836.
      Citations: 2     Fields:    Translation:Humans
    49. Cachia D, Alderson L, Smith T, Yunus S. Widely metastatic meningioma. Arch Neurol. 2012 Oct; 69(10):1372-3. PMID: 22776979.
      Citations: 2     Fields:    Translation:Humans
    50. Cachia D, Swearer J, Ferguson W, Moonis M. Selective cognitive patterns resulting from bilateral hippocampal ischemia. Arch Med Sci. 2011 Feb; 7(1):168-72. PMID: 22291752.
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