"ADAM12 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS.
Descriptor ID |
D000072199
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MeSH Number(s) |
D08.811.277.656.675.374.102.125 D09.400.430.500.125 D12.776.395.033.125
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Concept/Terms |
ADAM12 Protein- ADAM12 Protein
- ADAM-12 Protein
- Meltrin-alpha Protein
- Meltrin alpha Protein
- Disintegrin and Metalloproteinase Domain-Containing Protein 12
- Disintegrin and Metalloproteinase Domain Containing Protein 12
- ADAM 12 Protein
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Below are MeSH descriptors whose meaning is more general than "ADAM12 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAM12 Protein".
This graph shows the total number of publications written about "ADAM12 Protein" by people in this website by year, and whether "ADAM12 Protein" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "ADAM12 Protein" by people in Profiles.
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Fr?hlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara-Fujisawa A, Mercurio AM, Wewer UM. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res. 2011 Nov; 9(11):1449-61.
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Kveiborg M, Fr?hlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, Kronqvist P, Rank F, Mercurio AM, Wewer UM. A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res. 2005 Jun 01; 65(11):4754-61.
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Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, M?ller P, Mercurio AM, Albrechtsen R, Wewer UM. ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci. 2003 Oct 01; 116(Pt 19):3893-904.
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Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM. ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. J Biol Chem. 2003 Mar 14; 278(11):9576-84.