Proof of Concept Study

"Proof of Concept Study" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An empirical investigation which pertains to the development of prototypes or models that demonstrate the feasibility of novel concepts, ideas, principles, schema or their practical application.

Descriptor ID	D000075082
MeSH Number(s)	H01.770.644.578
Concept/Terms	Proof of Concept Study Proof of Concept Study Concept Study Proof Study Proof, Concept Proof of Concept Investigation Concept Investigation Proof Investigation Proof, Concept Proof of Concept Research Concept Research Proof Concept Research Proofs Research Proof, Concept Proof of Concept Testing Concept Testing Proof Concept Testing Proofs Testing Proof, Concept Testing Proofs, Concept Proof of Concept Experiment Concept Experiment Proof Concept Experiment Proofs Experiment Proof, Concept Proof of Concept Approach Approach Proof, Concept Approach Proofs, Concept Concept Approach Proof Concept Approach Proofs Proof of Concept Studies Proof of Concept Prototype Proof of Concept Prototype Concept Prototype Proof Concept Prototype Proofs Prototype Proof, Concept Proof of Concept Model Concept Model Proof Concept Model Proofs Model Proof, Concept Proof of Concept Evaluation Proof of Concept Evaluation Concept Evaluation Proof Concept Evaluation Proofs Evaluation Proof, Concept Proof of Concept Demonstration Concept Demonstration Proof Demonstration Proof, Concept

Below are MeSH descriptors whose meaning is more general than "Proof of Concept Study".

Natural Sciences [H]
Natural Science Disciplines [H01]
Science [H01.770]
Research [H01.770.644]
Proof of Concept Study [H01.770.644.578]

Below are MeSH descriptors whose meaning is related to "Proof of Concept Study".

Below are MeSH descriptors whose meaning is more specific than "Proof of Concept Study".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proof of Concept Study" by people in this website by year, and whether "Proof of Concept Study" was a major or minor topic of these publications.

Bar chart showing 28 publications over 10 distinct years, with a maximum of 7 publications in 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2016	0	1	1
2017	0	1	1
2018	0	5	5
2019	1	6	7
2020	0	7	7
2021	0	1	1
2022	0	2	2
2023	0	2	2
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "Proof of Concept Study" by people in Profiles.

Kurland J, Varadharaju V, Liu A, Stokes P, Gupta A, Hudspeth M, O'Connor B. Large Language Models' Ability to Assess Main Concepts in Story Retelling: A Proof-of-Concept Comparison of Human Versus Machine Ratings. Am J Speech Lang Pathol. 2025 Dec 15; 34(6S):3636-3646.

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Brink L, Romero RA, Coombs L, Tilkin M, Mazaheri S, Gichoya J, Zaiman Z, Trivedi H, Medina A, Bizzo BC, Chang K, Kalpathy-Cramer J, Kalra MK, Astuto B, Ramirez C, Majumdar S, Lee AY, Lee CI, Cross NM, Chen PH, Ciancibello M, Chiunda A, Nachand D, Shah C, Wald C. Multi-Institutional Evaluation and Training of Breast Density Classification AI Algorithm Using ACR Connect and AI-LAB. J Am Coll Radiol. 2025 02; 22(2):211-219.

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Houston KE, Singh M, Sedeh AE, Paschalis EI. A Magnetic Actuator Device for Fully Automated Blinking in Total Bidirectional Eyelid Paralysis: First Proof of Concept in a Human Participant. Transl Vis Sci Technol. 2024 05 01; 13(5):2.

View in: PubMed
Santangelo G, Pieters TA, Jalal MI, Rahmani R, Silberstein HJ, Stone JJ. Treatment of hydrocephalus in an ovine model with an intraparenchymal stent. J Neurosurg Pediatr. 2023 10 01; 32(4):437-446.

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Castiglione JA, Drake AW, Hussein AE, Johnson MD, Palmisciano P, Smith MS, Robinson MW, Stahl TL, Jandarov RA, Grossman AW, Shirani P, Forbes JA, Andaluz N, Zuccarello M, Prestigiacomo CJ. Complex Morphologic Analysis of Cerebral Aneurysms Through the Novel Use of Fractal Dimension as a Predictor of Rupture Status: A Proof of Concept Study. World Neurosurg. 2023 07; 175:e64-e72.

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Degrush E, Shazeeb MS, Drachman D, Vardar Z, Lindsay C, Gounis MJ, Henninger N. Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease. Alzheimers Res Ther. 2022 09 17; 14(1):134.

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Del Rosario RCH, Poschmann J, Lim C, Cheng CY, Kumar P, Riou C, Ong ST, Gerges S, Hajan HS, Kumar D, Marzuki M, Lu X, Lee A, Wijaya GC, Rayan NA, Zhuang Z, Du Bruyn E, Chee CBE, Lee B, Lum J, Zolezzi F, Poidinger M, Rotzschke O, Khor CC, Wilkinson RJ, Wang YT, Chandy GK, De Libero G, Singhal A, Prabhakar S. Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection. Nat Microbiol. 2022 02; 7(2):312-326.

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Dillon GA, Stanhewicz AE, Serviente C, Greaney JL, Alexander LM. Hydrogen sulfide-dependent microvascular vasodilation is improved following chronic sulfhydryl-donating antihypertensive pharmacotherapy in adults with hypertension. Am J Physiol Heart Circ Physiol. 2021 10 01; 321(4):H728-H734.

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Sood RN, Dudiki N, Alape D, Maxfiel MW. Healthcare Personnel Safety During Percutaneous Tracheostomy in Patients With COVID-19: Proof-of-Concept Study. J Intensive Care Med. 2021 May; 36(5):612-616.

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Bennike TB, Fatou B, Angelidou A, Diray-Arce J, Falsafi R, Ford R, Gill EE, van Haren SD, Idoko OT, Lee AH, Ben-Othman R, Pomat WS, Shannon CP, Smolen KK, Tebbutt SJ, Ozonoff A, Richmond PC, van den Biggelaar AHJ, Hancock REW, Kampmann B, Kollmann TR, Levy O, Steen H. Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life. Front Immunol. 2020; 11:578505.

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