Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
"Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The largest subunit of the anaphase-promoting complex. It acts primarily as a scaffold for the proper organization and arrangement of subunits. The C-terminal region of Apc1 contains a series of tandem amino acid repeats that are also seen in the 26S proteasome regulatory particle, and may assist with forming and stabilizing protein-protein interactions.
Descriptor ID |
D064189
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MeSH Number(s) |
D08.811.464.938.750.092.500 D12.776.167.024.500
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome".
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Below are the most recent publications written about "Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome" by people in Profiles.
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Tran K, Mahr JA, Choi J, Teodoro JG, Green MR, Spector DH. Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. J Virol. 2008 Jan; 82(1):529-37.
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Heilman DW, Teodoro JG, Green MR. Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies. J Virol. 2006 Aug; 80(15):7535-45.
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Teodoro JG, Heilman DW, Parker AE, Green MR. The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Genes Dev. 2004 Aug 15; 18(16):1952-7.