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Susan G Pfefferle PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentFamily Medicine and Community Health
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentFamily Medicine and Community Health

    Collapse Biography 
    Collapse education and training
    Earlham College, Richmond, IN, United StatesBAMusic
    University of Massachusetts Amherst, Amherst, MA, United StatesMED
    Brandeis University, Waltham, MA, United StatesPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pfl?ger LS, N?rz D, Grunwald M, Pfefferle S, Giersch K, Christner M, Weber B, Aepfelbacher M, Rohde H, L?tgehetmann M. Analytical and clinical validation of a multiplex PCR assay for detection of Neisseria gonorrhoeae and Chlamydia trachomatis including simultaneous LGV serotyping on an automated high-throughput PCR system. Microbiol Spectr. 2024 Mar 05; 12(3):e0275623. PMID: 38345391.
    2. Woo MS, Shafiq M, Fitzek A, Dottermusch M, Altmeppen H, Mohammadi B, Mayer C, Bal LC, Raich L, Matschke J, Krasemann S, Pfefferle S, Brehm TT, L?tgehetmann M, Sch?dler J, Addo MM, Schulze Zur Wiesch J, Ondruschka B, Friese MA, Glatzel M. Vagus nerve inflammation contributes to dysautonomia in COVID-19. Acta Neuropathol. 2023 09; 146(3):387-394. PMID: 37452829.
      Citations: 4     Fields:    Translation:HumansCells
    3. L?tgehetmann M, Albert E, Hamilton A, Jarem D, Pfefferle S, Stucki H, Navarro D. Evaluation of a Quantitative Dual-Target EBV DNA Test on a Fully Automated Molecular Testing System. J Clin Microbiol. 2023 08 23; 61(8):e0051823. PMID: 37432105.
      Citations:    Fields:    Translation:HumansCells
    4. Soh TK, Pfefferle S, Wurr S, von Possel R, Oestereich L, Rieger T, Uetrecht C, Rosenthal M, Bosse JB. A validated protocol to UV-inactivate SARS-CoV-2 and herpesvirus-infected cells. PLoS One. 2023; 18(5):e0274065. PMID: 37163509.
      Citations:    Fields:    Translation:HumansCells
    5. Knobloch JK, Pfefferle S, L?tgehetmann M, N?rz D, Klupp EM, Belmar Campos CE, Kluge S, Aepfelbacher M, Knobling B, Franke G. Infectivity of SARS-CoV-2 on Inanimate Surfaces: Don't Trust Ct Value. Int J Environ Res Public Health. 2022 Dec 19; 19(24). PMID: 36554950.
      Citations:    Fields:    
    6. Hermanussen L, Grewe I, Tang HT, N?rz D, Bal LC, Pfefferle S, Unger S, Hoffmann C, Berzow D, Kohsar M, Aepfelbacher M, Lohse AW, Addo MM, L?tgehetmann M, Schulze Zur Wiesch J, Schmiedel S. Tecovirimat therapy for severe monkeypox infection: Longitudinal assessment of viral titers and clinical response pattern-A first case-series experience. J Med Virol. 2023 01; 95(1):e28181. PMID: 36177717.
      Citations: 4     Fields:    Translation:Humans
    7. N?rz D, Brehm TT, Tang HT, Grewe I, Hermanussen L, Matthews H, Pestel J, Degen O, G?nther T, Grundhoff A, Fischer N, Addo MM, Jordan S, Hertling S, Unger S, Sch?fer G, Schewe K, Hoffmann C, Aepfelbacher M, Pfefferle S, Schulze Zur Wiesch J, Schmiedel S, L?tgehetmann M. Clinical characteristics and comparison of longitudinal qPCR results from different specimen types in a cohort of ambulatory and hospitalized patients infected with monkeypox virus. J Clin Virol. 2022 10; 155:105254. PMID: 36057206.
      Citations: 14     Fields:    Translation:HumansCells
    8. Olearo F, Radmanesh LS, Felber N, von Possel R, Emmerich P, Pekarek N, Pfefferle S, N?rz D, Hansen G, Diemert A, Aepfelbacher M, Hecher K, L?tgehetmann M, Arck PC, Tallarek AC. Anti-SARS-CoV-2 antibodies in breast milk during lactation after infection or vaccination: A cohort study. J Reprod Immunol. 2022 09; 153:103685. PMID: 36029724.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    9. Krasemann S, Dittmayer C, von Stillfried S, Meinhardt J, Heinrich F, Hartmann K, Pfefferle S, Thies E, von Manitius R, Aschman TAD, Radke J, Osterloh A, Schmid S, Buhl EM, Ihlow J, Dubois F, Arnhold V, Elezkurtaj S, Horst D, Hocke A, Timm S, Bachmann S, Corman V, Goebel HH, Matschke J, Stanelle-Bertram S, Gabriel G, Seilhean D, Adle-Biassette H, Ondruschka B, Ochs M, Stenzel W, Heppner FL, Boor P, Radbruch H, Laue M, Glatzel M. Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses. EBioMedicine. 2022 Sep; 83:104193. PMID: 35930888.
      Citations: 14     Fields:    Translation:HumansCells
    10. N?rz D, Tang HT, Emmerich P, Giersch K, Fischer N, Schmiedel S, Addo MM, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Rapid Adaptation of Established High-Throughput Molecular Testing Infrastructure for Monkeypox Virus Detection. Emerg Infect Dis. 2022 09; 28(9):1765-1769. PMID: 35905463.
      Citations: 3     Fields:    Translation:HumansCells
    11. Matschke J, Lahann H, Krasemann S, Altmeppen H, Pfefferle S, Galliciotti G, Fitzek A, Sperhake JP, Ondruschka B, Busch M, Rotermund N, Schulz K, Lohr C, Dottermusch M, Glatzel M. Young COVID-19 Patients Show a Higher Degree of Microglial Activation When Compared to Controls. Front Neurol. 2022; 13:908081. PMID: 35785352.
    12. Brehm TT, Pfefferle S, von Possel R, Karolyi M, Zoufaly A, Wichmann D, Kobbe R, Emmerich P, N?rz D, Aepfelbacher M, Schulze Zur Wiesch J, Addo MM, Schmiedel S, L?tgehetmann M. Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants. J Med Virol. 2022 10; 94(10):5038-5043. PMID: 35662058.
      Citations: 2     Fields:    Translation:HumansCells
    13. N?rz D, Pfefferle S, Brehm TT, Franke G, Grewe I, Knobling B, Aepfelbacher M, Huber S, Klupp EM, Jordan S, Addo MM, Schulze Zur Wiesch J, Schmiedel S, L?tgehetmann M, Knobloch JK. Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022. Euro Surveill. 2022 06; 27(26). PMID: 35775427.
      Citations: 11     Fields:    Translation:HumansCells
    14. Smeets R, Pfefferle S, B?ttner H, Knobloch JK, L?tgehetmann M. Impact of Oral Rinsing with Octenidine Based Solution on SARS-CoV-2 Loads in Saliva of Infected Patients an Exploratory Study. Int J Environ Res Public Health. 2022 05 04; 19(9). PMID: 35564977.
      Citations: 1     Fields:    Translation:HumansCells
    15. Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G, Barth P, Bohle RM, B?ttner A, B?ttner R, Dettmeyer R, Eichhorn P, Elezkurtaj S, Esposito I, Evert K, Evert M, Fend F, Ga?ler N, Gattenl?hner S, Glatzel M, G?bel H, Gradhand E, Hansen T, Hartmann A, Heinemann A, Heppner FL, Hilsenbeck J, Horst D, Kamp JC, Mall G, M?rkl B, Ondruschka B, Pablik J, Pfefferle S, Quaas A, Radbruch H, R?cken C, Rosenwald A, Roth W, Rudelius M, Schirmacher P, Slotta-Huspenina J, Smith K, Sommer L, Stock K, Str?bel P, Strobl S, Titze U, Weirich G, Weis J, Werner M, Wickenhauser C, Wiech T, Wild P, Welte T, von Stillfried S, Boor P. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Arch. 2022 Aug; 481(2):139-159. PMID: 35364700.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    16. Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, L?tgehetmann M, Meister E, Lu S, Noriega MLM, G?nther T, Grundhoff A, Fischer N, Br?uninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Molecular consequences of SARS-CoV-2 liver tropism. Nat Metab. 2022 03; 4(3):310-319. PMID: 35347318.
      Citations: 57     Fields:    Translation:HumansCells
    17. N?rz D, Grunwald M, Tang HT, Weinschenk C, G?nther T, Robitaille A, Giersch K, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants. Viruses. 2022 03 15; 14(3). PMID: 35337015.
      Citations: 5     Fields:    Translation:HumansCells
    18. Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, K?nig EM, Bodem J, Franzenburg S, Franke A, Moese S, M?ller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. Stem Cell Reports. 2022 02 08; 17(2):307-320. PMID: 35063125.
      Citations: 73     Fields:    Translation:HumansCells
    19. Heinrich F, Schr?der AS, Gerberding AL, Gerling M, Langenwalder F, Lange P, Heinemann A, Bibiza-Freiwald E, N?rz DS, Aepfelbacher M, Pfefferle S, Ondruschka B, L?tgehetmann M. Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths. Emerg Infect Dis. 2022 01; 28(1):244-247. PMID: 34726595.
      Citations: 4     Fields:    Translation:HumansCells
    20. Wenzel J, Lampe J, M?ller-Fielitz H, Schuster R, Zille M, M?ller K, Krohn M, K?rbelin J, Zhang L, ?zorhan ?, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, F?hnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Co?lho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, K?nig P, Busch H, Collin L, Villase?or R, J?hren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, P?schel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. 2021 11; 24(11):1522-1533. PMID: 34675436.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    21. Heinrich F, Nentwich MF, Bibiza-Freiwald E, N?rz D, Roedl K, Christner M, Hoffmann A, Olearo F, Kluge S, Aepfelbacher M, Wichmann D, L?tgehetmann M, Pfefferle S. SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients. Open Forum Infect Dis. 2021 Nov; 8(11):ofab509. PMID: 34796247.
    22. N?rz D, Grunwald M, Tang HT, Olearo F, G?nther T, Robitaille A, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection. Diagnostics (Basel). 2021 Oct 01; 11(10). PMID: 34679517.
    23. Olearo F, N?rz D, Hoffman A, Grunwald M, Gatzemeyer K, Christner M, Both A, Campos CEB, Braun P, Andersen G, Pfefferle S, Zapf A, Aepfelbacher M, Knobloch JKM, L?tgehetmann M. Clinical performance and accuracy of a qPCR-based SARS-CoV-2 mass-screening workflow for healthcare-worker surveillance using pooled self-sampled gargling solutions: A cross-sectional study. J Infect. 2021 11; 83(5):589-593. PMID: 34499947.
      Citations: 3     Fields:    Translation:HumansCells
    24. Pfl?ger LS, N?rz D, Volz T, Giersch K, Giese A, Goldmann N, Glebe D, Bockmann JH, Pfefferle S, Dandri M, Schulze Zur Wiesch J, L?tgehetmann M. Clinical establishment of a laboratory developed quantitative HDV PCR assay on the cobas6800 high-throughput system. JHEP Rep. 2021 Dec; 3(6):100356. PMID: 34712932.
    25. Apostolidou S, Harbauer T, Lasch P, Biermann D, Hempel M, L?tgehetmann M, Pfefferle S, Herrmann J, R?ffer A, Reinshagen K, Kozlik-Feldmann R, Gieras A, Kniep I, Oh J, Singer D, Ebenebe CU, Kobbe R. Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report. Children (Basel). 2021 Jun 30; 8(7). PMID: 34208887.
    26. N?rz D, Grunwald M, Olearo F, Fischer N, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with built-in screening functionality for del-HV69/70- and N501Y variants such as B.1.1.7. J Clin Virol. 2021 Aug; 141:104894. PMID: 34182299.
      Citations: 14     Fields:    Translation:HumansCells
    27. Schr?der AS, Edler C, Ondruschka B, P?schel K, Sch?dler J, Heinemann A, Heinrich F, L?tgehetmann M, Pfefferle S, Aepfelbacher M, Fitzek A, Sperhake JP. The handling of SARS-CoV-2 associated deaths?-?infectivity of the body. Forensic Sci Med Pathol. 2021 09; 17(3):411-418. PMID: 34076852.
      Citations: 13     Fields:    Translation:HumansCellsPHPublic Health
    28. N?rz D, Pfefferle S, Grunwald M, Fischer N, Aepfelbacher M, L?tgehetmann M. Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay. J Mol Diagn. 2021 06; 23(6):777-778. PMID: 33862239.
      Citations: 5     Fields:    Translation:HumansCells
    29. Brehm TT, Pfefferle S, von Possel R, Kobbe R, N?rz D, Schmiedel S, Grundhoff A, Olearo F, Emmerich P, Robitaille A, G?nther T, Braun P, Andersen G, Knobloch JK, Addo MM, Lohse AW, Aepfelbacher M, Fischer N, Schulze Zur Wiesch J, L?tgehetmann M. SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. Viruses. 2021 04 12; 13(4). PMID: 33921216.
      Citations: 17     Fields:    Translation:HumansCells
    30. Casagrande M, Fitzek A, Spitzer M, P?schel K, Glatzel M, Krasemann S, Aepfelbacher M, N?rz D, L?tgehetmann M, Pfefferle S, Schultheiss M. Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19. Br J Ophthalmol. 2022 09; 106(9):1313-1317. PMID: 33836988.
      Citations: 13     Fields:    Translation:HumansCells
    31. Casagrande M, Fitzek A, Spitzer MS, P?schel K, Glatzel M, Krasemann S, N?rz D, L?tgehetmann M, Pfefferle S, Schultheiss M. Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19. JAMA Ophthalmol. 2021 04 01; 139(4):383-388. PMID: 33475692.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    32. Olearo F, N?rz D, Heinrich F, Sutter JP, Roedl K, Schultze A, Wiesch JSZ, Braun P, Oestereich L, Kreuels B, Wichmann D, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR. J Clin Virol. 2021 04; 137:104782. PMID: 33711691.
      Citations: 24     Fields:    Translation:HumansCells
    33. Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schulthei? C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, L?tgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF. Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. Sci Immunol. 2021 02 23; 6(56). PMID: 33622974.
      Citations: 76     Fields:    Translation:HumansCells
    34. Fritzsche A, Berneking L, N?rz D, Reucher S, Fischer N, Roggenkamp H, Aepfelbacher M, Rohde H, Pfefferle S, L?tgehetmann M. Clinical evaluation of a laboratory-developed quantitative BK virus-PCR assay using the cobas? omni Utility Channel. J Virol Methods. 2021 04; 290:114093. PMID: 33549574.
      Citations:    Fields:    Translation:HumansCells
    35. N?rz D, Hoffmann A, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Clinical evaluation of a fully automated, laboratory-developed multiplex RT-PCR assay integrating dual-target SARS-CoV-2 and influenza A/B detection on a high-throughput platform. J Med Microbiol. 2021 Feb; 70(2). PMID: 33404401.
      Citations: 17     Fields:    Translation:HumansCells
    36. Roedl K, Heidenreich S, Pfefferle S, Jarczak D, Urbanowicz TT, N?rz D, Aepfelbacher M, Kr?ger N, Kluge S, L?tgehetmann M, Christopeit M, Wichmann D. Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19. Am J Respir Crit Care Med. 2021 01 15; 203(2):242-245. PMID: 33253054.
      Citations: 8     Fields:    Translation:HumansCells
    37. Heinrich F, Mei?ner K, Langenwalder F, P?schel K, N?rz D, Hoffmann A, L?tgehetmann M, Aepfelbacher M, Bibiza-Freiwald E, Pfefferle S, Heinemann A. Postmortem Stability of SARS-CoV-2 in Nasopharyngeal Mucosa. Emerg Infect Dis. 2021 01; 27(1). PMID: 33327991.
      Citations: 13     Fields:    Translation:HumansCells
    38. Ghandili S, Pfefferle S, Roedl K, Sonnemann P, Karagiannis P, Boenisch O, Kluge S, Schmiedel S, Ittrich H, Rohde H, L?tgehetmann M, Weisel K, Bokemeyer C, Wichmann D, Fiedler W, Jarczak D, Modemann F. Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients. Blood Adv. 2020 12 08; 4(23):5936-5941. PMID: 33275765.
      Citations: 10     Fields:    Translation:HumansCells
    39. Matschke J, L?tgehetmann M, Hagel C, Sperhake JP, Schr?der AS, Edler C, Mushumba H, Fitzek A, Allweiss L, Dandri M, Dottermusch M, Heinemann A, Pfefferle S, Schwabenland M, Sumner Magruder D, Bonn S, Prinz M, Gerloff C, P?schel K, Krasemann S, Aepfelbacher M, Glatzel M. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020 11; 19(11):919-929. PMID: 33031735.
      Citations: 578     Fields:    Translation:HumansCellsPHPublic Health
    40. Pfefferle S, G?nther T, Kobbe R, Czech-Sioli M, N?rz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch JK, L?tgehetmann M, Fischer N. SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany. Clin Microbiol Infect. 2021 Jan; 27(1):130.e5-130.e8. PMID: 33007476.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    41. N?rz D, Frontzek A, Eigner U, Oestereich L, Wichmann D, Kluge S, Fischer N, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Pushing beyond specifications: Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations. J Clin Virol. 2020 11; 132:104650. PMID: 33011643.
      Citations: 22     Fields:    Translation:HumansCells
    42. Braun F, L?tgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, N?rz D, Heinrich F, Mei?ner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schr?der AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB. SARS-CoV-2 renal tropism associates with acute kidney injury. Lancet. 2020 08 29; 396(10251):597-598. PMID: 32818439.
      Citations: 157     Fields:    Translation:HumansCellsPHPublic Health
    43. Pfl?ger LS, Bannasch JH, Brehm TT, Pfefferle S, Hoffmann A, N?rz D, van der Meirschen M, Kluge S, Haddad M, Pischke S, Hiller J, Addo MM, Lohse AW, Schulze Zur Wiesch J, Peine S, Aepfelbacher M, L?tgehetmann M. Clinical evaluation of five different automated SARS-CoV-2 serology assays in a cohort of hospitalized COVID-19 patients. J Clin Virol. 2020 09; 130:104549. PMID: 32763809.
      Citations: 26     Fields:    Translation:HumansCellsPHPublic Health
    44. Reisinger EC, von Possel R, Warnke P, Geerdes-Fenge HF, Hemmer CJ, Pfefferle S, L?bermann M, Littmann M, Emmerich P. [Screening of Mothers in a COVID-19 Low-Prevalence Region: Determination of SARS-CoV-2 Antibodies in 401 Mothers from Rostock by ELISA and Confirmation by Immunofluorescence]. Dtsch Med Wochenschr. 2020 08; 145(17):e96-e100. PMID: 32572869.
      Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
    45. Pfefferle S, Huang J, N?rz D, Indenbirken D, L?tgehetmann M, Oestereich L, G?nther T, Grundhoff A, Aepfelbacher M, Fischer N. Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany. Microbiol Resour Announc. 2020 Jun 04; 9(23). PMID: 32499358.
    46. Puelles VG, L?tgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schr?der AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. Multiorgan and Renal Tropism of SARS-CoV-2. N Engl J Med. 2020 08 06; 383(6):590-592. PMID: 32402155.
      Citations: 960     Fields:    Translation:HumansCellsPHPublic Health
    47. Wichmann D, Sperhake JP, L?tgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schr?der AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, P?schel K, Kluge S. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Ann Intern Med. 2020 08 18; 173(4):268-277. PMID: 32374815.
      Citations: 1241     Fields:    Translation:HumansCellsPHPublic Health
    48. N?rz D, Fischer N, Schultze A, Kluge S, Mayer-Runge U, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting. J Clin Virol. 2020 07; 128:104390. PMID: 32388471.
      Citations: 38     Fields:    Translation:HumansCellsPHPublic Health
    49. Pfefferle S, Reucher S, N?rz D, L?tgehetmann M. Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system. Euro Surveill. 2020 03; 25(9). PMID: 32156329.
      Citations: 136     Fields:    Translation:HumansCellsPHPublic Health
    50. Eigner U, N?rz D, Reucher S, Furrer J, Sun J, Chu K, Kolb M, Hefner N, Pfefferle S, L?tgehetmann M. Detection of C. difficile toxin as a model assay for performing fully automated high-throughput RT-PCR on clinical stool samples. J Microbiol Methods. 2020 05; 172:105882. PMID: 32119956.
      Citations: 1     Fields:    Translation:HumansCells
    51. Pfefferle S, Christner M, Aepfelbacher M, L?tgehetmann M, Rohde H. Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis. BMC Infect Dis. 2020 Feb 22; 20(1):170. PMID: 32087681.
      Citations: 8     Fields:    Translation:Humans
    52. Asar L, Pfefferle S, L?tgehetmann M, Hoffmann A, Katchanov J, Aepfelbacher M, Rohde H, Maurer FP. Influence of local epidemiology on the performance of common colistin drug susceptibility testing methods. PLoS One. 2019; 14(6):e0217468. PMID: 31170167.
      Citations:    Fields:    Translation:HumansCells
    53. Eigner U, Reucher S, Hefner N, Staffa-Peichl S, Kolb M, Betz U, Holfelder M, Spier G, Pfefferle S, L?tgehetmann M. Clinical evaluation of multiplex RT-PCR assays for the detection of influenza A/B and respiratory syncytial virus using a high throughput system. J Virol Methods. 2019 07; 269:49-54. PMID: 30946852.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    54. Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, L?cine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes. J Biol Chem. 2014 Sep 12; 289(37):25783-96. PMID: 25074927.
      Citations: 109     Fields:    Translation:HumansCells
    55. Struck AW, Axmann M, Pfefferle S, Drosten C, Meyer B. A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2. Antiviral Res. 2012 Jun; 94(3):288-96. PMID: 22265858.
      Citations: 51     Fields:    Translation:HumansCells
    56. Pfefferle S, Sch?pf J, K?gl M, Friedel CC, M?ller MA, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Kallies S, Niemeyer D, Ditt V, Kuri T, Z?st R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, P?hlmann S, Haas J, Drosten C, von Brunn A. The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog. 2011 Oct; 7(10):e1002331. PMID: 22046132.
      Citations: 260     Fields:    Translation:HumansAnimalsCells
    57. Glowacka I, Bertram S, M?ller MA, Allen P, Soilleux E, Pfefferle S, Steffen I, Tsegaye TS, He Y, Gnirss K, Niemeyer D, Schneider H, Drosten C, P?hlmann S. Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. J Virol. 2011 May; 85(9):4122-34. PMID: 21325420.
      Citations: 622     Fields:    Translation:HumansAnimalsCells
    58. Drexler JF, Gloza-Rausch F, Glende J, Corman VM, Muth D, Goettsche M, Seebens A, Niedrig M, Pfefferle S, Yordanov S, Zhelyazkov L, Hermanns U, Vallo P, Lukashev A, M?ller MA, Deng H, Herrler G, Drosten C. Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences. J Virol. 2010 Nov; 84(21):11336-49. PMID: 20686038.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    59. Zhou Y, Lu K, Pfefferle S, Bertram S, Glowacka I, Drosten C, P?hlmann S, Simmons G. A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms. J Virol. 2010 Sep; 84(17):8753-64. PMID: 20573835.
      Citations: 97     Fields:    Translation:HumansCells
    60. Panning M, Baumgarte S, Pfefferle S, Maier T, Martens A, Drosten C. Comparative analysis of rabies virus reverse transcription-PCR and virus isolation using samples from a patient infected with rabies virus. J Clin Microbiol. 2010 Aug; 48(8):2960-2. PMID: 20554825.
      Citations: 7     Fields:    Translation:HumansCells
    61. Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, P?hlmann S. Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J Virol. 2010 Jan; 84(2):1198-205. PMID: 19864379.
      Citations: 292     Fields:    Translation:HumansAnimalsCells
    62. Pfefferle S, Oppong S, Drexler JF, Gloza-Rausch F, Ipsen A, Seebens A, M?ller MA, Annan A, Vallo P, Adu-Sarkodie Y, Kruppa TF, Drosten C. Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana. Emerg Infect Dis. 2009 Sep; 15(9):1377-84. PMID: 19788804.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    63. Pfefferle S, Kr?hling V, Ditt V, Grywna K, M?hlberger E, Drosten C. Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo. Virol J. 2009 Aug 24; 6:131. PMID: 19698190.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    64. Voss D, Pfefferle S, Drosten C, Stevermann L, Traggiai E, Lanzavecchia A, Becker S. Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein. Virol J. 2009 Jun 18; 6:79. PMID: 19534833.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    65. Pfefferle SG, Cooper B, Layton D, Rohrbach S. Early collaboration for adaptation: addressing depression in low-income new mothers. J Health Care Poor Underserved. 2009 May; 20(2):539-44. PMID: 19395847.
      Citations: 3     Fields:    Translation:Humans
    66. Pfefferle SG, Spitznagel EL. CHILDREN'S MENTAL HEALTH SERVICE USE AND MATERNAL MENTAL HEALTH: A PATH ANALYTIC MODEL. Child Youth Serv Rev. 2009 Mar; 31(3):378-382. PMID: 20161315.
    67. Glende J, Schwegmann-Wessels C, Al-Falah M, Pfefferle S, Qu X, Deng H, Drosten C, Naim HY, Herrler G. Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. Virology. 2008 Nov 25; 381(2):215-21. PMID: 18814896.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    68. Bishop CE, Weinberg DB, Leutz W, Dossa A, Pfefferle SG, Zincavage RM. Nursing assistants' job commitment: effect of nursing home organizational factors and impact on resident well-being. Gerontologist. 2008 Jul; 48 Spec No 1:36-45. PMID: 18694985.
      Citations: 32     Fields:    Translation:Humans
    69. Pfefferle SG, Weinberg DB. Certified nurse assistants making meaning of direct care. Qual Health Res. 2008 Jul; 18(7):952-61. PMID: 18552321.
      Citations: 12     Fields:    Translation:Humans
    70. Gloza-Rausch F, Ipsen A, Seebens A, G?ttsche M, Panning M, Drexler JF, Petersen N, Annan A, Grywna K, M?ller M, Pfefferle S, Drosten C. Detection and prevalence patterns of group I coronaviruses in bats, northern Germany. Emerg Infect Dis. 2008 Apr; 14(4):626-31. PMID: 18400147.
      Citations: 117     Fields:    Translation:AnimalsCells
    71. Pfefferle SG. Pediatrician perspectives on children's access to mental health services: consequences and potential solutions. Adm Policy Ment Health. 2007 Sep; 34(5):425-34. PMID: 17436077.
      Citations: 8     Fields:    Translation:Humans
    72. Luna LK, Panning M, Grywna K, Pfefferle S, Drosten C. Spectrum of viruses and atypical bacteria in intercontinental air travelers with symptoms of acute respiratory infection. J Infect Dis. 2007 Mar 01; 195(5):675-9. PMID: 17262708.
      Citations: 26     Fields:    Translation:HumansCells
    73. Pfefferle SG, Gittell JH, Hodgkin D, Ritter G. Pediatrician coordination of care for children with mental illnesses. Med Care. 2006 Dec; 44(12):1085-91. PMID: 17122712.
      Citations: 1     Fields:    Translation:Humans
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