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Susan G Pfefferle PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentFamily Medicine and Community Health
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentFamily Medicine and Community Health


    Collapse Biography 
    Collapse education and training
    Earlham College, Richmond, IN, United StatesBAMusic
    University of Massachusetts Amherst, Amherst, MA, United StatesMED
    Brandeis University, Waltham, MA, United StatesPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brehm TT, Pfefferle S, von Possel R, Karolyi M, Zoufaly A, Wichmann D, Kobbe R, Emmerich P, Nörz D, Aepfelbacher M, Schulze Zur Wiesch J, Addo MM, Schmiedel S, Lütgehetmann M. Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants. J Med Virol. 2022 Jun 03. PMID: 35662058.
      Citations:    Fields:    
    2. Smeets R, Pfefferle S, Büttner H, Knobloch JK, Lütgehetmann M. Impact of Oral Rinsing with Octenidine Based Solution on SARS-CoV-2 Loads in Saliva of Infected Patients an Exploratory Study. Int J Environ Res Public Health. 2022 05 04; 19(9). PMID: 35564977.
      Citations:    Fields:    Translation:HumansCells
    3. Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G, Barth P, Bohle RM, Büttner A, Büttner R, Dettmeyer R, Eichhorn P, Elezkurtaj S, Esposito I, Evert K, Evert M, Fend F, Gaßler N, Gattenlöhner S, Glatzel M, Göbel H, Gradhand E, Hansen T, Hartmann A, Heinemann A, Heppner FL, Hilsenbeck J, Horst D, Kamp JC, Mall G, Märkl B, Ondruschka B, Pablik J, Pfefferle S, Quaas A, Radbruch H, Röcken C, Rosenwald A, Roth W, Rudelius M, Schirmacher P, Slotta-Huspenina J, Smith K, Sommer L, Stock K, Ströbel P, Strobl S, Titze U, Weirich G, Weis J, Werner M, Wickenhauser C, Wiech T, Wild P, Welte T, von Stillfried S, Boor P. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Arch. 2022 Apr 01. PMID: 35364700.
      Citations:    Fields:    
    4. Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Molecular consequences of SARS-CoV-2 liver tropism. Nat Metab. 2022 03; 4(3):310-319. PMID: 35347318.
      Citations:    Fields:    Translation:HumansCells
    5. Nörz D, Grunwald M, Tang HT, Weinschenk C, Günther T, Robitaille A, Giersch K, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants. Viruses. 2022 03 15; 14(3). PMID: 35337015.
      Citations:    Fields:    Translation:HumansCells
    6. Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A, Moese S, Müller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. Stem Cell Reports. 2022 02 08; 17(2):307-320. PMID: 35063125.
      Citations: 3     Fields:    Translation:HumansCells
    7. Heinrich F, Schröder AS, Gerberding AL, Gerling M, Langenwalder F, Lange P, Heinemann A, Bibiza-Freiwald E, Nörz DS, Aepfelbacher M, Pfefferle S, Ondruschka B, Lütgehetmann M. Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths. Emerg Infect Dis. 2022 01; 28(1):244-247. PMID: 34726595.
      Citations:    Fields:    Translation:HumansCells
    8. Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. 2021 11; 24(11):1522-1533. PMID: 34675436.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    9. Heinrich F, Nentwich MF, Bibiza-Freiwald E, Nörz D, Roedl K, Christner M, Hoffmann A, Olearo F, Kluge S, Aepfelbacher M, Wichmann D, Lütgehetmann M, Pfefferle S. SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients. Open Forum Infect Dis. 2021 Nov; 8(11):ofab509. PMID: 34796247.
      Citations:    
    10. Nörz D, Grunwald M, Tang HT, Olearo F, Günther T, Robitaille A, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection. Diagnostics (Basel). 2021 Oct 01; 11(10). PMID: 34679517.
      Citations:    
    11. Olearo F, Nörz D, Hoffman A, Grunwald M, Gatzemeyer K, Christner M, Both A, Campos CEB, Braun P, Andersen G, Pfefferle S, Zapf A, Aepfelbacher M, Knobloch JKM, Lütgehetmann M. Clinical performance and accuracy of a qPCR-based SARS-CoV-2 mass-screening workflow for healthcare-worker surveillance using pooled self-sampled gargling solutions: A cross-sectional study. J Infect. 2021 11; 83(5):589-593. PMID: 34499947.
      Citations:    Fields:    Translation:HumansCells
    12. Pflüger LS, Nörz D, Volz T, Giersch K, Giese A, Goldmann N, Glebe D, Bockmann JH, Pfefferle S, Dandri M, Schulze Zur Wiesch J, Lütgehetmann M. Clinical establishment of a laboratory developed quantitative HDV PCR assay on the cobas6800 high-throughput system. JHEP Rep. 2021 Dec; 3(6):100356. PMID: 34712932.
      Citations:    
    13. Apostolidou S, Harbauer T, Lasch P, Biermann D, Hempel M, Lütgehetmann M, Pfefferle S, Herrmann J, Rüffer A, Reinshagen K, Kozlik-Feldmann R, Gieras A, Kniep I, Oh J, Singer D, Ebenebe CU, Kobbe R. Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report. Children (Basel). 2021 Jun 30; 8(7). PMID: 34208887.
      Citations:    
    14. Nörz D, Grunwald M, Olearo F, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with built-in screening functionality for del-HV69/70- and N501Y variants such as B.1.1.7. J Clin Virol. 2021 Aug; 141:104894. PMID: 34182299.
      Citations: 7     Fields:    Translation:HumansCells
    15. Schröder AS, Edler C, Ondruschka B, Püschel K, Schädler J, Heinemann A, Heinrich F, Lütgehetmann M, Pfefferle S, Aepfelbacher M, Fitzek A, Sperhake JP. The handling of SARS-CoV-2 associated deaths - infectivity of the body. Forensic Sci Med Pathol. 2021 09; 17(3):411-418. PMID: 34076852.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    16. Nörz D, Pfefferle S, Grunwald M, Fischer N, Aepfelbacher M, Lütgehetmann M. Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay. J Mol Diagn. 2021 06; 23(6):777-778. PMID: 33862239.
      Citations: 3     Fields:    Translation:HumansCells
    17. Brehm TT, Pfefferle S, von Possel R, Kobbe R, Nörz D, Schmiedel S, Grundhoff A, Olearo F, Emmerich P, Robitaille A, Günther T, Braun P, Andersen G, Knobloch JK, Addo MM, Lohse AW, Aepfelbacher M, Fischer N, Schulze Zur Wiesch J, Lütgehetmann M. SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. Viruses. 2021 04 12; 13(4). PMID: 33921216.
      Citations: 10     Fields:    Translation:HumansCells
    18. Casagrande M, Fitzek A, Spitzer M, Püschel K, Glatzel M, Krasemann S, Aepfelbacher M, Nörz D, Lütgehetmann M, Pfefferle S, Schultheiss M. Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19. Br J Ophthalmol. 2021 Apr 09. PMID: 33836988.
      Citations: 6     Fields:    
    19. Casagrande M, Fitzek A, Spitzer MS, Püschel K, Glatzel M, Krasemann S, Nörz D, Lütgehetmann M, Pfefferle S, Schultheiss M. Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19. JAMA Ophthalmol. 2021 04 01; 139(4):383-388. PMID: 33475692.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    20. Olearo F, Nörz D, Heinrich F, Sutter JP, Roedl K, Schultze A, Wiesch JSZ, Braun P, Oestereich L, Kreuels B, Wichmann D, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR. J Clin Virol. 2021 04; 137:104782. PMID: 33711691.
      Citations: 11     Fields:    Translation:HumansCells
    21. Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF. Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. Sci Immunol. 2021 02 23; 6(56). PMID: 33622974.
      Citations: 35     Fields:    Translation:HumansCells
    22. Fritzsche A, Berneking L, Nörz D, Reucher S, Fischer N, Roggenkamp H, Aepfelbacher M, Rohde H, Pfefferle S, Lütgehetmann M. Clinical evaluation of a laboratory-developed quantitative BK virus-PCR assay using the cobas® omni Utility Channel. J Virol Methods. 2021 04; 290:114093. PMID: 33549574.
      Citations:    Fields:    Translation:HumansCells
    23. Nörz D, Hoffmann A, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Clinical evaluation of a fully automated, laboratory-developed multiplex RT-PCR assay integrating dual-target SARS-CoV-2 and influenza A/B detection on a high-throughput platform. J Med Microbiol. 2021 Feb; 70(2). PMID: 33404401.
      Citations: 9     Fields:    Translation:HumansCells
    24. Roedl K, Heidenreich S, Pfefferle S, Jarczak D, Urbanowicz TT, Nörz D, Aepfelbacher M, Kröger N, Kluge S, Lütgehetmann M, Christopeit M, Wichmann D. Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19. Am J Respir Crit Care Med. 2021 01 15; 203(2):242-245. PMID: 33253054.
      Citations: 7     Fields:    Translation:HumansCells
    25. Heinrich F, Meißner K, Langenwalder F, Püschel K, Nörz D, Hoffmann A, Lütgehetmann M, Aepfelbacher M, Bibiza-Freiwald E, Pfefferle S, Heinemann A. Postmortem Stability of SARS-CoV-2 in Nasopharyngeal Mucosa. Emerg Infect Dis. 2021 01; 27(1). PMID: 33327991.
      Citations: 9     Fields:    Translation:HumansCells
    26. Ghandili S, Pfefferle S, Roedl K, Sonnemann P, Karagiannis P, Boenisch O, Kluge S, Schmiedel S, Ittrich H, Rohde H, Lütgehetmann M, Weisel K, Bokemeyer C, Wichmann D, Fiedler W, Jarczak D, Modemann F. Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients. Blood Adv. 2020 12 08; 4(23):5936-5941. PMID: 33275765.
      Citations: 7     Fields:    Translation:HumansCells
    27. Matschke J, Lütgehetmann M, Hagel C, Sperhake JP, Schröder AS, Edler C, Mushumba H, Fitzek A, Allweiss L, Dandri M, Dottermusch M, Heinemann A, Pfefferle S, Schwabenland M, Sumner Magruder D, Bonn S, Prinz M, Gerloff C, Püschel K, Krasemann S, Aepfelbacher M, Glatzel M. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020 11; 19(11):919-929. PMID: 33031735.
      Citations: 282     Fields:    Translation:HumansCellsPHPublic Health
    28. Pfefferle S, Günther T, Kobbe R, Czech-Sioli M, Nörz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch JK, Lütgehetmann M, Fischer N. SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany. Clin Microbiol Infect. 2021 Jan; 27(1):130.e5-130.e8. PMID: 33007476.
      Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
    29. Nörz D, Frontzek A, Eigner U, Oestereich L, Wichmann D, Kluge S, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Pushing beyond specifications: Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations. J Clin Virol. 2020 11; 132:104650. PMID: 33011643.
      Citations: 19     Fields:    Translation:HumansCells
    30. Braun F, Lütgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, Nörz D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schröder AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB. SARS-CoV-2 renal tropism associates with acute kidney injury. Lancet. 2020 08 29; 396(10251):597-598. PMID: 32818439.
      Citations: 108     Fields:    Translation:HumansCellsPHPublic Health
    31. Pflüger LS, Bannasch JH, Brehm TT, Pfefferle S, Hoffmann A, Nörz D, van der Meirschen M, Kluge S, Haddad M, Pischke S, Hiller J, Addo MM, Lohse AW, Schulze Zur Wiesch J, Peine S, Aepfelbacher M, Lütgehetmann M. Clinical evaluation of five different automated SARS-CoV-2 serology assays in a cohort of hospitalized COVID-19 patients. J Clin Virol. 2020 09; 130:104549. PMID: 32763809.
      Citations: 19     Fields:    Translation:HumansCellsPHPublic Health
    32. Reisinger EC, von Possel R, Warnke P, Geerdes-Fenge HF, Hemmer CJ, Pfefferle S, Löbermann M, Littmann M, Emmerich P. [Screening of Mothers in a COVID-19 Low-Prevalence Region: Determination of SARS-CoV-2 Antibodies in 401 Mothers from Rostock by ELISA and Confirmation by Immunofluorescence]. Dtsch Med Wochenschr. 2020 08; 145(17):e96-e100. PMID: 32572869.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    33. Pfefferle S, Huang J, Nörz D, Indenbirken D, Lütgehetmann M, Oestereich L, Günther T, Grundhoff A, Aepfelbacher M, Fischer N. Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany. Microbiol Resour Announc. 2020 Jun 04; 9(23). PMID: 32499358.
      Citations:    
    34. Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. Multiorgan and Renal Tropism of SARS-CoV-2. N Engl J Med. 2020 08 06; 383(6):590-592. PMID: 32402155.
      Citations: 673     Fields:    Translation:HumansCellsPHPublic Health
    35. Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schröder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Püschel K, Kluge S. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Ann Intern Med. 2020 08 18; 173(4):268-277. PMID: 32374815.
      Citations: 902     Fields:    Translation:HumansCellsPHPublic Health
    36. Nörz D, Fischer N, Schultze A, Kluge S, Mayer-Runge U, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting. J Clin Virol. 2020 07; 128:104390. PMID: 32388471.
      Citations: 31     Fields:    Translation:HumansCellsPHPublic Health
    37. Pfefferle S, Reucher S, Nörz D, Lütgehetmann M. Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system. Euro Surveill. 2020 03; 25(9). PMID: 32156329.
      Citations: 107     Fields:    Translation:HumansCellsPHPublic Health
    38. Eigner U, Nörz D, Reucher S, Furrer J, Sun J, Chu K, Kolb M, Hefner N, Pfefferle S, Lütgehetmann M. Detection of C. difficile toxin as a model assay for performing fully automated high-throughput RT-PCR on clinical stool samples. J Microbiol Methods. 2020 05; 172:105882. PMID: 32119956.
      Citations: 1     Fields:    Translation:HumansCells
    39. Pfefferle S, Christner M, Aepfelbacher M, Lütgehetmann M, Rohde H. Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis. BMC Infect Dis. 2020 Feb 22; 20(1):170. PMID: 32087681.
      Citations: 4     Fields:    Translation:Humans
    40. Asar L, Pfefferle S, Lütgehetmann M, Hoffmann A, Katchanov J, Aepfelbacher M, Rohde H, Maurer FP. Influence of local epidemiology on the performance of common colistin drug susceptibility testing methods. PLoS One. 2019; 14(6):e0217468. PMID: 31170167.
      Citations:    Fields:    Translation:HumansCells
    41. Eigner U, Reucher S, Hefner N, Staffa-Peichl S, Kolb M, Betz U, Holfelder M, Spier G, Pfefferle S, Lütgehetmann M. Clinical evaluation of multiplex RT-PCR assays for the detection of influenza A/B and respiratory syncytial virus using a high throughput system. J Virol Methods. 2019 07; 269:49-54. PMID: 30946852.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    42. Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes. J Biol Chem. 2014 Sep 12; 289(37):25783-96. PMID: 25074927.
      Citations: 82     Fields:    Translation:HumansCells
    43. Struck AW, Axmann M, Pfefferle S, Drosten C, Meyer B. A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2. Antiviral Res. 2012 Jun; 94(3):288-96. PMID: 22265858.
      Citations: 37     Fields:    Translation:HumansCells
    44. Pfefferle S, Schöpf J, Kögl M, Friedel CC, Müller MA, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Kallies S, Niemeyer D, Ditt V, Kuri T, Züst R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, Pöhlmann S, Haas J, Drosten C, von Brunn A. The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog. 2011 Oct; 7(10):e1002331. PMID: 22046132.
      Citations: 217     Fields:    Translation:HumansAnimalsCells
    45. Glowacka I, Bertram S, Müller MA, Allen P, Soilleux E, Pfefferle S, Steffen I, Tsegaye TS, He Y, Gnirss K, Niemeyer D, Schneider H, Drosten C, Pöhlmann S. Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. J Virol. 2011 May; 85(9):4122-34. PMID: 21325420.
      Citations: 490     Fields:    Translation:HumansAnimalsCells
    46. Drexler JF, Gloza-Rausch F, Glende J, Corman VM, Muth D, Goettsche M, Seebens A, Niedrig M, Pfefferle S, Yordanov S, Zhelyazkov L, Hermanns U, Vallo P, Lukashev A, Müller MA, Deng H, Herrler G, Drosten C. Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences. J Virol. 2010 Nov; 84(21):11336-49. PMID: 20686038.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    47. Zhou Y, Lu K, Pfefferle S, Bertram S, Glowacka I, Drosten C, Pöhlmann S, Simmons G. A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms. J Virol. 2010 Sep; 84(17):8753-64. PMID: 20573835.
      Citations: 79     Fields:    Translation:HumansCells
    48. Panning M, Baumgarte S, Pfefferle S, Maier T, Martens A, Drosten C. Comparative analysis of rabies virus reverse transcription-PCR and virus isolation using samples from a patient infected with rabies virus. J Clin Microbiol. 2010 Aug; 48(8):2960-2. PMID: 20554825.
      Citations: 7     Fields:    Translation:HumansCells
    49. Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, Pöhlmann S. Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J Virol. 2010 Jan; 84(2):1198-205. PMID: 19864379.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    50. Pfefferle S, Oppong S, Drexler JF, Gloza-Rausch F, Ipsen A, Seebens A, Müller MA, Annan A, Vallo P, Adu-Sarkodie Y, Kruppa TF, Drosten C. Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana. Emerg Infect Dis. 2009 Sep; 15(9):1377-84. PMID: 19788804.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    51. Pfefferle S, Krähling V, Ditt V, Grywna K, Mühlberger E, Drosten C. Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo. Virol J. 2009 Aug 24; 6:131. PMID: 19698190.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    52. Voss D, Pfefferle S, Drosten C, Stevermann L, Traggiai E, Lanzavecchia A, Becker S. Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein. Virol J. 2009 Jun 18; 6:79. PMID: 19534833.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    53. Pfefferle SG, Cooper B, Layton D, Rohrbach S. Early collaboration for adaptation: addressing depression in low-income new mothers. J Health Care Poor Underserved. 2009 May; 20(2):539-44. PMID: 19395847.
      Citations: 3     Fields:    Translation:Humans
    54. Pfefferle SG, Spitznagel EL. CHILDREN'S MENTAL HEALTH SERVICE USE AND MATERNAL MENTAL HEALTH: A PATH ANALYTIC MODEL. Child Youth Serv Rev. 2009 Mar; 31(3):378-382. PMID: 20161315.
      Citations:    
    55. Glende J, Schwegmann-Wessels C, Al-Falah M, Pfefferle S, Qu X, Deng H, Drosten C, Naim HY, Herrler G. Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. Virology. 2008 Nov 25; 381(2):215-21. PMID: 18814896.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    56. Bishop CE, Weinberg DB, Leutz W, Dossa A, Pfefferle SG, Zincavage RM. Nursing assistants' job commitment: effect of nursing home organizational factors and impact on resident well-being. Gerontologist. 2008 Jul; 48 Spec No 1:36-45. PMID: 18694985.
      Citations: 26     Fields:    Translation:Humans
    57. Pfefferle SG, Weinberg DB. Certified nurse assistants making meaning of direct care. Qual Health Res. 2008 Jul; 18(7):952-61. PMID: 18552321.
      Citations: 10     Fields:    Translation:Humans
    58. Gloza-Rausch F, Ipsen A, Seebens A, Göttsche M, Panning M, Drexler JF, Petersen N, Annan A, Grywna K, Müller M, Pfefferle S, Drosten C. Detection and prevalence patterns of group I coronaviruses in bats, northern Germany. Emerg Infect Dis. 2008 Apr; 14(4):626-31. PMID: 18400147.
      Citations: 101     Fields:    Translation:AnimalsCells
    59. Pfefferle SG. Pediatrician perspectives on children's access to mental health services: consequences and potential solutions. Adm Policy Ment Health. 2007 Sep; 34(5):425-34. PMID: 17436077.
      Citations: 6     Fields:    Translation:Humans
    60. Luna LK, Panning M, Grywna K, Pfefferle S, Drosten C. Spectrum of viruses and atypical bacteria in intercontinental air travelers with symptoms of acute respiratory infection. J Infect Dis. 2007 Mar 01; 195(5):675-9. PMID: 17262708.
      Citations: 25     Fields:    Translation:HumansCells
    61. Pfefferle SG, Gittell JH, Hodgkin D, Ritter G. Pediatrician coordination of care for children with mental illnesses. Med Care. 2006 Dec; 44(12):1085-91. PMID: 17122712.
      Citations: 1     Fields:    Translation:Humans
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