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Jean Pierre Schatzmann Peron PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentNeurology
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience


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    Our lab is focused on investigating cellular and molecular mechanisms of immune response and neuropathogenesis during viral infection, as ZIKV and SARS-CoV-2. Also, we test the potential of endometrial derived Mesenchymal Stem Cells (eMSCs) and their extracellular vesicles as a therapeutic tool to mitigate neuroinflammation.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peron JPS. Direct and indirect impact of SARS-CoV-2 on the brain. Hum Genet. 2023 Aug; 142(8):1317-1326. PMID: 37004544.
      Citations: 2     Fields:    Translation:HumansCells
    2. Polonio CM, da Silva P, Russo FB, Hyppolito BRN, Zanluqui NG, Benazzato C, Beltr?o-Braga PCB, Muxel SM, Peron JPS. microRNAs Control Antiviral Immune Response, Cell Death and Chemotaxis Pathways in Human Neuronal Precursor Cells (NPCs) during Zika Virus Infection. Int J Mol Sci. 2022 Sep 07; 23(18). PMID: 36142200.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    3. de Oliveira LG, de Souza Angelo Y, Yamamoto P, Carregari VC, Crunfli F, Reis-de-Oliveira G, Costa L, Vendramini PH, Duque ?A, Dos Santos NB, Firmino EM, Paiva IM, Almeida GM, Sebollela A, Polonio CM, Zanluqui NG, de Oliveira MG, da Silva P, Davanzo GG, Ayupe MC, Salgado CL, de Souza Filho AF, de Ara?jo MV, Silva-Pereira TT, de Almeida Campos AC, G?es LGB, Dos Passos Cunha M, Caldini EG, D'Imp?rio Lima MR, Fonseca DM, de S? Guimar?es AM, Minoprio PC, Munhoz CD, Mori CMC, Moraes-Vieira PM, Cunha TM, Martins-de-Souza D, Peron JPS. SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes. J Neurochem. 2022 10; 163(2):113-132. PMID: 35880385.
      Citations: 12     Fields:    Translation:AnimalsCells
    4. Cunha MDP, Vilela APP, Molina CV, Acu?a SM, Muxel SM, Barroso VM, Baroni S, Gomes de Oliveira L, Angelo YS, Peron JPS, G?es LGB, Campos ACA, Min?prio P. Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient. Front Med (Lausanne). 2021; 8:760170. PMID: 34901074.
      Citations:    
    5. Fragoso YD, Gomes S, Gon?alves MVM, Mendes Junior E, Oliveira BES, Rocha CF, Santos GACD, Tauil CB, Araujo RV, Peron JPS. New relapse of multiple sclerosis and neuromyelitis optica as a potential adverse event of AstraZeneca AZD1222 vaccination for COVID-19. Mult Scler Relat Disord. 2022 Jan; 57:103321. PMID: 35158439.
      Citations: 19     Fields:    Translation:HumansCellsPHPublic Health
    6. Polonio CM, Peron JPS. ZIKV Infection and miRNA Network in Pathogenesis and Immune Response. Viruses. 2021 10 04; 13(10). PMID: 34696422.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. de Freitas CL, Polonio CM, Brand?o WN, Rossato C, Zanluqui NG, de Oliveira LG, de Oliveira MG, Evangelista LP, Halpern S, Maluf M, Czresnia CE, Perin P, de Almeida DC, Peron JPS. Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System. Stem Cell Rev Rep. 2022 02; 18(2):609-625. PMID: 34453694.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Silva-Filho JL, de Oliveira LG, Monteiro L, Parise PL, Zanluqui NG, Polonio CM, de Freitas CL, Toledo-Teixeira DA, de Souza WM, Bittencourt N, Amorim MR, Forato J, Muraro SP, de Souza GF, Martini MC, Bispo-Dos-Santos K, Vieira A, Judice CC, Pastore GM, Amaral E, Passini Junior R, Mayer-Milanez HMBP, Ribeiro-do-Valle CC, Calil R, Renato Bennini Junior J, Lajos GJ, Altemani A, Nolasco da Silva MT, Carolina Coan A, Francisca Colella-Santos M, von Zuben APB, Vinolo MAR, Arns CW, Catharino RR, Costa ML, Angerami RN, Freitas ARR, Resende MR, Garcia MT, Luiza Moretti M, Renia L, Ng LFP, Rothlin CV, Costa FTM, Peron JPS, Proen?a-Modena JL. Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. Brain Behav Immun. 2021 10; 97:260-274. PMID: 34390806.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Manganeli Polonio C, Longo de Freitas C, Garcia de Oliveira M, Rossato C, Nogueira Brand?o W, Ghabdan Zanluqui N, Gomes de Oliveira L, Ayumi Nishiyama Mimura L, Braga Barros Silva M, L?cia Garcia Calich V, Gil Nisenbaum M, Halpern S, Evangelista L, Maluf M, Perin P, Eduardo Czeresnia C, Schatzmann Peron JP. Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression. Clin Sci (Lond). 2021 05 14; 135(9):1065-1082. PMID: 33960391.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. de Oliveira LG, Angelo YS, Iglesias AH, Peron JPS. Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation. Front Immunol. 2021; 12:624919. PMID: 33796100.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    11. Pinto BGG, Oliveira AER, Singh Y, Jimenez L, Gon?alves ANA, Ogava RLT, Creighton R, Schatzmann Peron JP, Nakaya HI. ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19. J Infect Dis. 2020 07 23; 222(4):556-563. PMID: 32526012.
      Citations: 210     Fields:    Translation:HumansCellsPHPublic Health
    12. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Guti?rrez-V?zquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 08; 23(8):939-951. PMID: 32690969.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    13. Peron JPS, Nakaya H. Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE). Clinics (Sao Paulo). 2020; 75:e1912. PMID: 32428113.
      Citations: 45     Fields:    Translation:HumansCellsPHPublic Health
    14. Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng'ang'a D, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Agarwal A, Brinkman AL, Cabral C, Chandrashekar A, Giglio PB, Jetton D, Jimenez J, Lee BC, Mojta S, Molloy K, Shetty M, Neubauer GH, Stephenson KE, Peron JP, Zanotto PM, Misamore J, Finneyfrock B, Lewis MG, Alter G, Modjarrad K, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science. 2016 09 09; 353(6304):1129-32. PMID: 27492477.
      Citations: 276     Fields:    Translation:HumansAnimalsCells
    15. Larocca RA, Abbink P, Peron JP, Zanotto PM, Iampietro MJ, Badamchi-Zadeh A, Boyd M, Ng'ang'a D, Kirilova M, Nityanandam R, Mercado NB, Li Z, Moseley ET, Bricault CA, Borducchi EN, Giglio PB, Jetton D, Neubauer G, Nkolola JP, Maxfield LF, De La Barrera RA, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Vaccine protection against Zika virus from Brazil. Nature. 2016 08 25; 536(7617):474-8. PMID: 27355570.
      Citations: 287     Fields:    Translation:HumansAnimalsCells
    16. Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimar?es KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brand?o WN, Rossato C, Andrade DG, Faria Dde P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PM, Peron JP, Muotri AR, Beltr?o-Braga PC. The Brazilian Zika virus strain causes birth defects in experimental models. Nature. 2016 06 09; 534(7606):267-71. PMID: 27279226.
      Citations: 667     Fields:    Translation:AnimalsCells
    17. Peron JP, Jazedje T, Brand?o WN, Perin PM, Maluf M, Evangelista LP, Halpern S, Nisenbaum MG, Czeresnia CE, Zatz M, C?mara NO, Rizzo LV. Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice. Stem Cell Rev Rep. 2012 Sep; 8(3):940-52. PMID: 22180029.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    18. Peron JP, Yang K, Chen ML, Brandao WN, Basso AS, Commodaro AG, Weiner HL, Rizzo LV. Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice. J Neuroimmunol. 2010 Oct 08; 227(1-2):10-7. PMID: 20580440.
      Citations: 33     Fields:    Translation:AnimalsCells
    19. Peron JP, de Oliveira AP, Rizzo LV. It takes guts for tolerance: the phenomenon of oral tolerance and the regulation of autoimmune response. Autoimmun Rev. 2009 Sep; 9(1):1-4. PMID: 19224711.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    20. Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B, Carrier Y, Masli S, Rizzo LV, Weiner HL. Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis. J Autoimmun. 2009 Mar; 32(2):94-103. PMID: 19181483.
      Citations: 26     Fields:    Translation:AnimalsCells
    21. Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007 Dec; 8(12):1380-9. PMID: 17994022.
      Citations: 417     Fields:    Translation:HumansAnimalsCells
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