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Marie Sophie Lykke Isidor PhD

TitleAdjunct Assistant Professor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressNOVO Nordisk Foundation Center for Basic Metabolic Rese
Blegdamsvej 3B, 7th Floor
2200 Copenhagen N.
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    Collapse Biography 
    Collapse education and training
    University of Copenhagen, Copenhagen, , DenmarkBSBiology
    University of Copenhagen, Copenhagen, , DenmarkMSBiology
    University of Copenhagen, Copenhagen, , DenmarkPHDBiomedical Sciences

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. Functional genomic screens with death rate analyses reveal mechanisms of drug action. Nat Chem Biol. 2024 Mar 13. PMID: 38480981.
    2. Lund J, Isidor MS, Gerhart-Hines Z. MCT1 helps brown fat suck up succinate. Nat Metab. 2024 Mar; 6(3):387-388. PMID: 38378995.
    3. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Cruz-Gordillo P, Porto SA, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. p53 controls choice between apoptotic and non-apoptotic death following DNA damage. bioRxiv. 2023 May 16. PMID: 36712034.
    4. Lund J, Breum AW, Gil C, Falk S, Sass F, Isidor MS, Dmytriyeva O, Ranea-Robles P, Mathiesen CV, Basse AL, Johansen OS, Fadahunsi N, Lund C, Nicolaisen TS, Klein AB, Ma T, Emanuelli B, Kleinert M, S?rensen CM, Gerhart-Hines Z, Clemmensen C. The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions. Nat Metab. 2023 04; 5(4):677-698. PMID: 37055619.
      Citations: 6     Fields:    Translation:Animals
    5. Rupar K, Isidor MS, Argemi-Muntadas L, Agueda-Oyarzabal M, Plucinska K, Brown EL, Mattanovich M, Bossi S, Tozzi M, Tandio D, Petersen PSS, Henriksen TI, Tro?t K, Hansen JB, Gerhart-Hines Z, Nielsen S, Moritz T, Emanuelli B. Full activation of thermogenesis in brown adipocytes requires Basigin action. FEBS J. 2023 05; 290(10):2673-2691. PMID: 36595342.
      Citations:    Fields:    Translation:AnimalsCells
    6. Isidor MS, Dong W, Servin-Uribe RI, Villarroel J, Altintas A, Ayala-Sumuano JT, Varela-Echavarr?a A, Barr?s R, Stephanopoulos G, Macotela Y, Emanuelli B. Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes. Int J Obes (Lond). 2022 03; 46(3):535-543. PMID: 34799672.
      Citations: 1     Fields:    Translation:HumansCells
    7. Tozzi M, Brown EL, Petersen PSS, Lundh M, Isidor MS, Plucinska K, Nielsen TS, Agueda-Oyarzabal M, Small L, Treebak JT, Emanuelli B. Dynamic interplay between AfadinS1795 phosphorylation and diet regulates glucose homeostasis in obese mice. J Physiol. 2022 02; 600(4):885-902. PMID: 34387373.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, Dong H, Christensen DP, Sun W, Gnad T, Karavaeva I, Nielsen TS, Kooijman S, Cero C, Dmytriyeva O, Shen Y, Razzoli M, O'Brien SL, Kuipers EN, Nielsen CH, Orchard W, Willemsen N, Jespersen NZ, Lundh M, Sustarsic EG, Hallgren CM, Frost M, McGonigle S, Isidor MS, Broholm C, Pedersen O, Hansen JB, Grarup N, Hansen T, Kj?r A, Granneman JG, Babu MM, Calebiro D, Nielsen S, Ryd?n M, Soccio R, Rensen PCN, Treebak JT, Schwartz TW, Emanuelli B, Bartolomucci A, Pfeifer A, Zechner R, Scheele C, Mandrup S, Gerhart-Hines Z. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell. 2021 06 24; 184(13):3502-3518.e33. PMID: 34048700.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    9. Rabiee A, Plucinska K, Isidor MS, Brown EL, Tozzi M, Sidoli S, Petersen PSS, Agueda-Oyarzabal M, Torsetnes SB, Chehabi GN, Lundh M, Altintas A, Barr?s R, Jensen ON, Gerhart-Hines Z, Emanuelli B. White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment. Mol Metab. 2021 02; 44:101137. PMID: 33285300.
      Citations: 6     Fields:    Translation:AnimalsCells
    10. Isidor MS, Winther S, Markussen LK, Basse AL, Quistorff B, Nedergaard J, Emanuelli B, Hansen JB. Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes. FEBS Lett. 2020 04; 594(7):1218-1225. PMID: 31823361.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Lundh M, Petersen PS, Isidor MS, Kazoka-S?rensen DN, Plucinska K, Shamsi F, ?rskov C, Tozzi M, Brown EL, Andersen E, Ma T, M?ller U, Barr?s R, Kristiansen VB, Gerhart-Hines Z, Tseng YH, Emanuelli B. Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue. EMBO Rep. 2019 08; 20(8):e48216. PMID: 31264358.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Banhos Danneskiold-Sams?e N, Sonne SB, Larsen JM, Hansen AN, Fj?re E, Isidor MS, Petersen S, Henningsen J, Severi I, Sartini L, Schober Y, Wolf J, Nockher WA, Wolfrum C, Cinti S, Sina C, Hansen JB, Madsen L, Brix S, Kristiansen K. Overexpression of cyclooxygenase-2 in adipocytes reduces fat accumulation in inguinal white adipose tissue and hepatic steatosis in high-fat fed mice. Sci Rep. 2019 06 20; 9(1):8979. PMID: 31222118.
      Citations: 11     Fields:    Translation:AnimalsCells
    13. Winther S, Isidor MS, Basse AL, Skjoldborg N, Cheung A, Quistorff B, Hansen JB. Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption. Am J Physiol Endocrinol Metab. 2018 03 01; 314(3):E214-E223. PMID: 29118013.
      Citations: 31     Fields:    Translation:AnimalsCells
    14. Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF. MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism. Sci Rep. 2017 10 12; 7(1):13101. PMID: 29026134.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    15. Markussen LK, Isidor MS, Breining P, Andersen ES, Rasmussen NE, Petersen LI, Pedersen SB, Richelsen B, Hansen JB. Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. PLoS One. 2017; 12(9):e0185624. PMID: 28957413.
      Citations: 11     Fields:    Translation:HumansCells
    16. Lundh M, Pluci?ska K, Isidor MS, Petersen PSS, Emanuelli B. Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA. Mol Metab. 2017 10; 6(10):1313-1320. PMID: 29031730.
      Citations: 22     Fields:    Translation:AnimalsCells
    17. Basse AL, Isidor MS, Winther S, Skjoldborg NB, Murholm M, Andersen ES, Pedersen SB, Wolfrum C, Quistorff B, Hansen JB. Regulation of glycolysis in brown adipocytes by HIF-1a. Sci Rep. 2017 06 22; 7(1):4052. PMID: 28642579.
      Citations: 22     Fields:    Translation:AnimalsCells
    18. Isidor MS, Winther S, Basse AL, Petersen MC, Cannon B, Nedergaard J, Hansen JB. An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes. Adipocyte. 2016 Apr-Jun; 5(2):175-85. PMID: 27386153.
      Citations: 26     Fields:    
    19. Viby NE, Isidor MS, Buggeskov KB, Poulsen SS, Hansen JB, Kissow H. Glucagon-like peptide-1 (GLP-1) reduces mortality and improves lung function in a model of experimental obstructive lung disease in female mice. Endocrinology. 2013 Dec; 154(12):4503-11. PMID: 24092637.
      Citations: 50     Fields:    Translation:HumansAnimals
    20. Murholm M, Isidor MS, Basse AL, Winther S, S?rensen C, Skovgaard-Petersen J, Nielsen MM, Hansen AS, Quistorff B, Hansen JB. Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes. BMC Cell Biol. 2013 Sep 23; 14:41. PMID: 24059847.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    21. Dixen K, Basse AL, Murholm M, Isidor MS, Hansen LH, Petersen MC, Madsen L, Petrovic N, Nedergaard J, Quistorff B, Hansen JB. ERR? enhances UCP1 expression and fatty acid oxidation in brown adipocytes. Obesity (Silver Spring). 2013 Mar; 21(3):516-24. PMID: 23404793.
      Citations: 16     Fields:    Translation:AnimalsCells
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