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Tianmin Fu PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentPathology
AddressUMass Chan Medical School
368 Plantation Street, ASC
Worcester MA 01605
Phone508-856-2521
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentPathology

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentSystems Computational and Quantitative Biology


    Collapse Biography 
    Collapse education and training
    Shandong University, Jinan, , ChinaBSBiological Sciences
    Peking University, Beijing, , ChinaPHDBiochemistry and Molecular Bio

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rish AD, Fosuah E, Shen Z, Marathe IA, Wysocki VH, Fu TM. Architecture remodeling activates the HerA-DUF anti-phage defense system. Mol Cell. 2025 Mar 20; 85(6):1189-1201.e5. PMID: 40010344.
      Citations:    
    2. Rish AD, Fosuah E, Shen Z, Marathe IA, Wysocki VH, Fu TM. Topological rearrangements activate the HerA-DUF anti-phage defense system. bioRxiv. 2024 Oct 24. PMID: 39484427.
      Citations:    
    3. Wang C, Shen Z, Yang XY, Fu TM. Structures and functions of short argonautes. RNA Biol. 2024 01; 21(1):1-7. PMID: 39219231.
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    4. Yang XY, Shen Z, Wang C, Nakanishi K, Fu TM. DdmDE eliminates plasmid invasion by DNA-guided DNA targeting. Cell. 2024 Sep 19; 187(19):5253-5266.e16. PMID: 39173632.
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    5. Yang XY, Shen Z, Wang C, Nakanishi K, Fu TM. DdmDE eliminates plasmid invasion by DNA-guided DNA targeting. bioRxiv. 2024 Jul 20. PMID: 39071313.
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    6. Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM. Molecular basis of Gabija anti-phage supramolecular assemblies. Nat Struct Mol Biol. 2024 Aug; 31(8):1243-1250. PMID: 38627580.
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    7. Li Y, Shen Z, Zhang M, Yang XY, Cleary SP, Xie J, Marathe IA, Kostelic M, Greenwald J, Rish AD, Wysocki VH, Chen C, Chen Q, Fu TM, Yu Y. PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense. Nat Struct Mol Biol. 2024 Mar; 31(3):413-423. PMID: 38177683.
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    8. Shen Z, Lin Q, Yang XY, Fosuah E, Fu TM. Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol Cell. 2023 Dec 21; 83(24):4586-4599.e5. PMID: 38096827.
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    9. Solebo O, Ling L, Nwankwo I, Zhou J, Fu TM, Ke H. Plasmodium falciparum utilizes pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage. PLoS Pathog. 2023 Dec; 19(12):e1011818. PMID: 38048362.
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    10. Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR. TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron. 2023 10 18; 111(20):3195-3210.e7. PMID: 37543036.
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    11. Shen Z, Yang XY, Xia S, Huang W, Taylor DJ, Nakanishi K, Fu TM. Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature. 2023 Sep; 621(7977):154-161. PMID: 37494956.
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    12. Rish AD, Shen Z, Chen Z, Zhang N, Zheng Q, Fu TM. Molecular mechanisms of Holliday junction branch migration catalyzed by an asymmetric RuvB hexamer. Nat Commun. 2023 06 15; 14(1):3549. PMID: 37322069.
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    13. Cheng J, Yu Y, Wang X, Zheng X, Liu T, Hu D, Jin Y, Lai Y, Fu TM, Chen Q. Structural basis for the self-recognition of sDSCAM in Chelicerata. Nat Commun. 2023 05 02; 14(1):2522. PMID: 37130844.
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    14. Rish AD, Fu TM. CRISPR-Cas has a new juggling act: interplay between nuclease and protease. Nat Struct Mol Biol. 2023 02; 30(2):126-128. PMID: 36721057.
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    15. Uddin N, Binzel DW, Shu D, Fu TM, Guo P. Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome. Acta Pharm Sin B. 2023 Apr; 13(4):1383-1399. PMID: 37139430.
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    16. Wang L, Wu D, Robinson CV, Fu TM. Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining. Proc Natl Acad Sci U S A. 2022 08 30; 119(35):e2203742119. PMID: 35994636.
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    17. Fontana P, Dong Y, Pi X, Tong AB, Hecksel CW, Wang L, Fu TM, Bustamante C, Wu H. Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold. Science. 2022 06 10; 376(6598):eabm9326. PMID: 35679401.
      Citations:    
    18. Zhao JS, Shi S, Qu HY, Keckesova Z, Cao ZJ, Yang LX, Yu X, Feng L, Shi Z, Krakowiak J, Mao RY, Shen YT, Fan YM, Fu TM, Ye C, Xu D, Gao X, You J, Li W, Liang T, Lu Z, Feng YX. Author Correction: Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth. Nat Metab. 2022 Jun; 4(6):791. PMID: 35637348.
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    19. Zheng W, Shen C, Wang L, Rawson S, Xie WJ, Nist-Lund C, Wu J, Shen Z, Xia S, Holt JR, Wu H, Fu TM. pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Sci Adv. 2022 Mar 25; 8(12):eabm1568. PMID: 35333573.
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    20. Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). PMID: 35149555.
      Citations:    
    21. Zhao JS, Shi S, Qu HY, Keckesova Z, Cao ZJ, Yang LX, Yu X, Feng L, Shi Z, Krakowiak J, Mao RY, Shen YT, Fan YM, Fu TM, Ye C, Xu D, Gao X, You J, Li W, Liang T, Lu Z, Feng YX. Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth. Nat Metab. 2022 02; 4(2):239-253. PMID: 35145325.
      Citations:    
    22. Rish AD, Shen Z, Fu TM. It takes two to Tango: Two gates orchestrate the opening of human TRPM2. Cell Calcium. 2022 01; 101:102523. PMID: 34973600.
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    23. Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 11 11; 184(23):5759-5774.e20. PMID: 34678144.
      Citations:    
    24. Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021 05; 593(7860):607-611. PMID: 33883744.
      Citations:    
    25. Xia S, Chen Z, Shen C, Fu TM. Higher-order assemblies in immune signaling: supramolecular complexes and phase separation. Protein Cell. 2021 09; 12(9):680-694. PMID: 33835418.
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    26. Wu C, Tang D, Cheng J, Hu D, Yang Z, Ma X, He H, Yao S, Fu TM, Yu Y, Chen Q. Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res. 2021 03 18; 49(5):2973-2984. PMID: 33619565.
      Citations:    
    27. Wang L, Chen Z, Wu H, Fu TM. Purification and cryoelectron microscopy structure determination of human V-ATPase. STAR Protoc. 2021 03 19; 2(1):100350. PMID: 33665630.
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    28. Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun. 2021 01 08; 12(1):189. PMID: 33420033.
      Citations:    
    29. Wang L, Wu D, Robinson CV, Wu H, Fu TM. Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol Cell. 2020 11 05; 80(3):501-511.e3. PMID: 33065002.
      Citations:    
    30. Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H. SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. bioRxiv. 2020 Sep 18. PMID: 32995777.
      Citations:    
    31. Yin L, Masuyer G, Zhang S, Zhang J, Miyashita SI, Burgin D, Lovelock L, Coker SF, Fu TM, Stenmark P, Dong M. Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. PLoS Biol. 2020 03; 18(3):e3000618. PMID: 32182233.
      Citations:    
    32. Xia S, Wang L, Fu TM, Wu H. Mechanism of TRPM2 channel gating revealed by cryo-EM. FEBS J. 2019 09; 286(17):3333-3339. PMID: 31144442.
      Citations:    
    33. Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 05 17; 364(6441). PMID: 31097636.
      Citations:    
    34. Pan L, Fu TM, Zhao W, Zhao L, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S, Wu H, Chou JJ. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell. 2019 03 07; 176(6):1477-1489.e14. PMID: 30827683.
      Citations:    
    35. Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2052-2057. PMID: 30674671.
      Citations:    
    36. Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H. Structures and gating mechanism of human TRPM2. Science. 2018 12 21; 362(6421). PMID: 30467180.
      Citations:    
    37. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 2018 10 25; 7. PMID: 30355448.
      Citations:    
    38. Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):10845-10852. PMID: 30279182.
      Citations:    
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