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Cintia Folgueira PhD

TitleAdjunct Assistant Professor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressHealth Research Institute Foundation
Santiago de Compostela (A Coruna), Spain 15706
Phone34645590629
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine


    Collapse Biography 
    Collapse education and training
    Universidade de Santiago de Compostela, A Coruna, , SpainBSBiology
    Universidade de Santiago de Compostela, A Coruna, , SpainMSNeuroscience
    Universidade de Santiago de Compostela, A Coruna, , SpainPHDEndocrinology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cicu?ndez B, Mora A, L?pez JA, Curtabbi A, P?rez-Garc?a J, Porteiro B, Jimenez-Blasco D, Latorre-Muro P, Vo P, Jerome M, G?mez-Santos B, Romero-Becerra R, Leiva M, Rodr?guez E, Le?n M, Leiva-Vega L, G?mez-Lado N, Torres JL, Hern?ndez-Cosido L, Aguiar P, Marcos M, Jastroch M, Daiber A, Aspichueta P, Bola?os JP, Spinelli JB, Puigserver P, Enriquez JA, V?zquez J, Folgueira C, Sabio G. Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis. Nat Commun. 2025 Jan 13; 16(1):229. PMID: 39805849.
      Citations:    
    2. Aboy-Pardal MCM, Guadamillas MC, Guerrero CR, Catal?-Montoro M, Toledano-Donado M, Terr?s-Dom?nguez S, Pav?n DM, Jim?nez-Jim?nez V, Jimenez-Carretero D, Zamai M, Folgueira C, Cerezo A, Lolo FN, Nogueiras R, Sabio G, S?nchez-?lvarez M, Echarri A, Garcia R, Del Pozo MA. Plasma membrane remodeling determines adipocyte expansion and mechanical adaptability. Nat Commun. 2024 11 28; 15(1):10102. PMID: 39609408.
      Citations:    
    3. Valdecantos MP, Ruiz L, Folgueira C, Rada P, Gomez-Santos B, Solas M, Hitos AB, Field J, Francisco V, Escalona-Garrido C, Zagmutt S, Calderon-Dominguez M, Mera P, Garcia-Martinez I, Maym?-Masip E, Grajales D, Alen R, Mora A, S?inz N, Vides-Urrestarazu I, Vilarrasa N, Arbones-Mainar JM, Zaragoza C, Moreno-Aliaga MJ, Aspichueta P, Fern?ndez-Veledo S, Vendrell J, Serra D, Herrero L, Schreiber R, Zechner R, Sabio G, Hornigold D, Rondinone CM, Jermutus L, Grimsby J, Valverde ?M. The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk. Nat Commun. 2024 11 28; 15(1):10342. PMID: 39609390.
      Citations:    
    4. Herrera-Melle L, Cicu?ndez B, L?pez JA, Dumesic PA, Wilensky SE, Rodr?guez E, Leiva-Vega L, Caballero A, Le?n M, V?zquez J, Spiegelman BM, Folgueira C, Mora A, Sabio G. p38a kinase governs muscle strength through PGC1a in mice. Acta Physiol (Oxf). 2024 Nov; 240(11):e14234. PMID: 39361268.
      Citations:    
    5. Folgueira C, Herrera-Melle L, L?pez JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, Garc?a-Culebras A, Dumesic PA, Rodr?guez E, Leiva-Vega L, Le?n M, Porteiro B, Iglesias C, Torres JL, Hern?ndez-Cosido L, Bonacasa C, Marcos M, Moro M?, V?zquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G. Remodeling p38 signaling in muscle controls locomotor activity via IL-15. Sci Adv. 2024 Aug 16; 10(33):eadn5993. PMID: 39141732.
      Citations:    
    6. Duquenne M, Deligia E, Folgueira C, Bourouh C, Caron E, Pfrieger F, Schwaninger M, Nogueiras R, Annicotte JS, Imbernon M, Pr?vot V. Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice. Mol Metab. 2024 Sep; 87:101996. PMID: 39047908.
      Citations:    
    7. Ferreira V, Folgueira C, Montes-San Lorenzo ?, Rodr?guez-L?pez A, Gonzalez-Iglesias E, Zubiaur P, Abad-Santos F, Sabio G, Rada P, Valverde ?M. Estrogens prevent the hypothalamus-periphery crosstalk induced by olanzapine intraperitoneal treatment in female mice: Effects on brown/beige adipose tissues and liver. Biochim Biophys Acta Mol Basis Dis. 2024 06; 1870(5):167227. PMID: 38733774.
      Citations:    
    8. Cicu?ndez B, P?rez-Garc?a J, Folgueira C. A Combination of a Dopamine Receptor 2 Agonist and a Kappa Opioid Receptor Antagonist Synergistically Reduces Weight in Diet-Induced Obese Rodents. Nutrients. 2024 Jan 31; 16(3). PMID: 38337707.
      Citations:    
    9. Ferreira V, Folgueira C, Garc?a-Altares M, Guill?n M, Ru?z-Rosario M, DiNunzio G, Garcia-Martinez I, Alen R, Bookmeyer C, Jones JG, Cigudosa JC, L?pez-Larrubia P, Correig-Blanchar X, Davis RJ, Sabio G, Rada P, Valverde ?M. Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. Redox Biol. 2023 07; 63:102741. PMID: 37230004.
      Citations:    
    10. Ferreira V, Folgueira C, Guill?n M, Zubiaur P, Navares M, Sarsenbayeva A, L?pez-Larrubia P, Eriksson JW, Pereira MJ, Abad-Santos F, Sabio G, Rada P, Valverde ?M. Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight. Metabolism. 2022 12; 137:155335. PMID: 36272468.
      Citations:    
    11. Pena-Leon V, Folgueira C, Barja-Fern?ndez S, P?rez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, Gonz?lez-Saenz P, V?zquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, L?pez M, Tovar S, Casanueva FF, Valjent E, Di?guez C, Prevot V, Nogueiras R, Seoane LM. Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. Nat Metab. 2022 07; 4(7):901-917. PMID: 35879461.
      Citations:    
    12. Rodriguez-Mu?oz D, S?nchez ?, P?rez-Benavente S, Contreras-Jurado C, Montero-Pedrazuela A, Toledo-Castillo M, Guti?rrez-Hern?ndez M, Rodrigues-D?ez R, Folgueira C, Briones AM, Sabio G, Monedero-Cobeta I, Chaves-Coira I, Castej?n D, Fern?ndez-Valle E, Regadera J, Bautista JM, Aranda A, Alemany S. Hypothyroidism confers tolerance to cerebral malaria. Sci Adv. 2022 04 08; 8(14):eabj7110. PMID: 35385300.
      Citations:    
    13. S?enz de Urturi D, Buqu? X, Porteiro B, Folgueira C, Mora A, Delgado TC, Prieto-Fern?ndez E, Olaizola P, G?mez-Santos B, Apodaka-Biguri M, Gonz?lez-Romero F, Nieva-Zuluaga A, Ruiz de Gauna M, Goikoetxea-Usandizaga N, Garc?a-Rodr?guez JL, Gutierrez de Juan V, Aurrekoetxea I, Montalvo-Romeral V, Novoa EM, Mart?n-Guerrero I, Varela-Rey M, Bhanot S, Lee R, Banales JM, Syn WK, Sabio G, Mart?nez-Chantar ML, Nogueiras R, Aspichueta P. Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis. Nat Commun. 2022 03 01; 13(1):1096. PMID: 35232994.
      Citations:    
    14. Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Pr?vot V. Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function. Nat Metab. 2021 08; 3(8):1071-1090. PMID: 34341568.
      Citations:    
    15. Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodr?guez E, Leiva-Vega L, Pintor-Chocano A, Fern?ndez-Chac?n M, Ruiz-Garrido I, Cicu?ndez B, Tom?s-Loba A, A-Gonzalez N, Caballero-Molano A, Beiroa D, Hern?ndez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. Elife. 2020 12 08; 9. PMID: 33287957.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    16. Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hern?ndez-Cosido L, Blanco ?, Arab JP, Barrera F, Guallar D, Fidalgo M, L?pez M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R. The L-a-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis. Hepatology. 2021 02; 73(2):606-624. PMID: 32329085.
      Citations:    
    17. Romero-Becerra R, Santamans AM, Folgueira C, Sabio G. p38 MAPK Pathway in the Heart: New Insights in Health and Disease. Int J Mol Sci. 2020 Oct 08; 21(19). PMID: 33049962.
      Citations:    
    18. Manieri E, Folgueira C, Rodr?guez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, G?mez MJ, Monte MJ, G Marin JJ, Davis RJ, Mora A, Sabio G. JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16492-16499. PMID: 32601222.
      Citations:    
    19. Folgueira C, Torres-Leal FL, Beiroa D, Pena-Le?n V, Da Silva Lima N, Milbank E, Senra A, Al-Massadi O, L?pez M, Di?guez C, Seoane LM, Nogueiras R. Oral Pharmacological Activation of Hypothalamic Guanylate Cyclase 2C Receptor Stimulates Brown Fat Thermogenesis to Reduce Body Weight. Neuroendocrinology. 2020; 110(11-12):1042-1054. PMID: 31945763.
      Citations:    
    20. Al-Massadi O, Qui?ones M, Clasadonte J, Hernandez-Bautista R, Romero-Pic? A, Folgueira C, Morgan DA, Kall? I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, Garc?a-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. Diabetes. 2019 12; 68(12):2210-2222. PMID: 31530579.
      Citations:    
    21. Seoane-Collazo P, Li?ares-Pose L, Rial-Pensado E, Romero-Pic? A, Moreno-Navarrete JM, Mart?nez-S?nchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-Garc?a JL, Nogueiras R, Domingos AI, Fern?ndez-Real JM, Rahmouni K, Di?guez C, L?pez M. Central nicotine induces browning through hypothalamic ? opioid receptor. Nat Commun. 2019 09 06; 10(1):4037. PMID: 31492869.
      Citations:    
    22. Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, Barja-Fern?ndez S, Gallego R, Hern?ndez-Bautista R, Castelao C, Senra A, Seoane P, G?mez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-Garc?a JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Fr?hbeck G, Seoane LM, Nogueiras R. Hypothalamic dopamine signaling regulates brown fat thermogenesis. Nat Metab. 2019 08; 1(8):811-829. PMID: 31579887.
      Citations:    
    23. Barja-Fern?ndez S, Folgueira C, Castelao C, Pena-Le?n V, Gonz?lez-Saenz P, V?zquez-Cobela R, Aguilera CM, Gil-Campos M, Bueno G, Gil ?, Moreno LA, Ruiz-Pi?on M, Garc?a-Palacios M, Casanueva FF, Di?guez C, Nogueiras R, Leis R, Seoane LM. ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients. 2019 Jun 14; 11(6). PMID: 31207920.
      Citations:    
    24. Folgueira C, Beiroa D, Gonz?lez-Rell?n MJ, Porteiro B, Milbank E, Castelao C, Garc?a-Palacios M, Casanueva FF, L?pez M, Di?guez C, Seoane LM, Nogueiras R. Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice. Nutrients. 2019 Mar 30; 11(4). PMID: 30935076.
      Citations:    
    25. Carreira MC, Andrade S, Gonzalez-Izquierdo A, Amil M, Folgueira C, Monteiro MP, Sanz E, Crujeiras AB, Casanueva FF. Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain. Sci Rep. 2018 11 21; 8(1):17155. PMID: 30464239.
      Citations:    
    26. Folgueira C, Barja-Fern?ndez S, Gonzalez-Saenz P, Castelao C, V?zquez-Cobela R, Pena-Leon V, Ruiz-Pi?on M, Casanueva FF, Dieguez C, Leis R, Nogueiras R, Seoane LM. Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty. Sci Rep. 2018 09 28; 8(1):14541. PMID: 30266914.
      Citations:    
    27. Qui?ones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-T?volli R, Garc?a-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fern? J, Malagon MM, Contreras R, Pfluger P, Br?ning JC, Yeo G, Tsch?p M, Di?guez C, L?pez M, Claret M, Kloppenburg P, Sabio G, Nogueiras R. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nat Commun. 2018 08 24; 9(1):3432. PMID: 30143607.
      Citations:    
    28. Barja-Fernandez S, Moreno-Navarrete JM, Folgueira C, Xifra G, Sabater M, Castelao C, Fern? J, Leis R, Di?guez C, Casanueva FF, Ricart W, Seoane LM, Fernandez-Real JM, Nogueiras R. Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings. Mol Nutr Food Res. 2018 05; 62(10):e1800060. PMID: 29536615.
      Citations:    
    29. Romero-Pic? A, Sanchez-Rebordelo E, Imbernon M, Gonz?lez-Touceda D, Folgueira C, Senra A, Fern? J, Blouet C, Cabrera R, van Gestel M, Adan RA, L?pez M, Maldonado R, Nogueiras R, Di?guez C. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018 03 01; 130:62-70. PMID: 29191753.
      Citations:    
    30. Folgueira C, Barja-Fernandez S, Prado L, Al-Massadi O, Castelao C, Pena-Leon V, Gonzalez-Saenz P, Baltar J, Baamonde I, Leis R, Dieguez C, Pagotto U, Casanueva FF, Tovar SA, Nogueiras R, Seoane LM. Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway. World J Gastroenterol. 2017 Sep 21; 23(35):6403-6411. PMID: 29085189.
      Citations:    
    31. Imbernon M, Sanchez-Rebordelo E, Romero-Pic? A, Kall? I, Chee MJ, Porteiro B, Al-Massadi O, Contreras C, Fern? J, Senra A, Gallego R, Folgueira C, Seoane LM, van Gestel M, Adan RA, Liposits Z, Dieguez C, L?pez M, Nogueiras R. Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress. Hepatology. 2016 10; 64(4):1086-104. PMID: 27387967.
      Citations:    
    32. Barja-Fernandez S, Folgueira C, Castelao C, Leis R, Crujeiras AB, Casanueva FF, Seoane LM. Regulation of Growth Hormone by the Splanchnic Area. Prog Mol Biol Transl Sci. 2016; 138:41-60. PMID: 26940386.
      Citations:    
    33. Folgueira C, Beiroa D, Callon A, Al-Massadi O, Barja-Fernandez S, Senra A, Fern? J, L?pez M, Dieguez C, Casanueva FF, Rohner-Jeanrenaud F, Seoane LM, Nogueiras R. Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways. Diabetes. 2016 Feb; 65(2):421-32. PMID: 26566631.
      Citations:    
    34. Qui?ones M, Folgueira C, S?nchez-Rebordelo E, Al-Massadi O. Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents. Mediators Inflamm. 2015; 2015:620919. PMID: 26568663.
      Citations:    
    35. Barja-Fern?ndez S, Folgueira C, Seoane LM, Casanueva FF, Dieguez C, Castelao C, Ag?era Z, Ba?os R, Botella C, de la Torre R, Fern?ndez-Garc?a JC, Fern?ndez-Real JM, Fr?hbeck G, G?mez-Ambrosi J, Jim?nez-Murcia S, Tinahones FJ, Estivill X, Fern?ndez-Aranda F, Nogueiras R. Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women. J Clin Endocrinol Metab. 2015 Sep; 100(9):E1188-96. PMID: 26171798.
      Citations:    
    36. Senin LL, Al-Massadi O, Barja-Fernandez S, Folgueira C, Castelao C, Tovar SA, Leis R, Lago F, Baltar J, Baamonde I, Dieguez C, Casanueva FF, Seoane LM. Regulation of NUCB2/nesfatin-1 production in rat's stomach and adipose tissue is dependent on age, testosterone levels and lactating status. Mol Cell Endocrinol. 2015 Aug 15; 411:105-12. PMID: 25916958.
      Citations:    
    37. Barja-Fern?ndez S, Folgueira C, Castelao C, Leis R, Casanueva FF, Seoane LM. Peripheral signals mediate the beneficial effects of gastric surgery in obesity. Gastroenterol Res Pract. 2015; 2015:560938. PMID: 25960740.
      Citations:    
    38. Senin LL, Roca-Rivada A, Castelao C, Alonso J, Folgueira C, Casanueva FF, Pardo M, Seoane LM. Comparative secretome analysis of rat stomach under different nutritional status. Data Brief. 2015 Jun; 3:62-6. PMID: 26217719.
      Citations:    
    39. Senin LL, Roca-Rivada A, Castelao C, Alonso J, Folgueira C, Casanueva FF, Pardo M, Seoane LM. Comparative secretome analysis of rat stomach under different nutritional status. J Proteomics. 2015 Feb 26; 116:44-58. PMID: 25579404.
      Citations:    
    40. Senin LL, Al-Massadi O, Folgueira C, Castelao C, Pardo M, Barja-Fernandez S, Roca-Rivada A, Amil M, Crujeiras AB, Garcia-Caballero T, Gabellieri E, Leis R, Dieguez C, Pagotto U, Casanueva FF, Seoane LM. The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake. PLoS One. 2013; 8(11):e80339. PMID: 24303008.
      Citations:    
    41. Romero-Pic? A, Novelle MG, Folgueira C, L?pez M, Nogueiras R, Di?guez C. Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin. Psychopharmacology (Berl). 2013 Sep; 229(2):275-83. PMID: 23624808.
      Citations:    
    42. Romero-Pic? A, V?zquez MJ, Gonz?lez-Touceda D, Folgueira C, Skibicka KP, Alvarez-Crespo M, Van Gestel MA, Vel?squez DA, Schwarzer C, Herzog H, L?pez M, Adan RA, Dickson SL, Di?guez C, Nogueiras R. Hypothalamic ?-opioid receptor modulates the orexigenic effect of ghrelin. Neuropsychopharmacology. 2013 Jun; 38(7):1296-307. PMID: 23348063.
      Citations:    
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