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Kerstin Nundel PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
55 Lake Avenue North LRB 240B
Worcester MA 01655
Phone508-856-8588
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionRheumatology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program


    Collapse Biography 
    Collapse education and training
    Thomas Jefferson University, Philadelphia, PA, United StatesPHDImmunology
    University of Massachusetts Medical School, Worcester, MA, United States2013
    Boston University , Boston, MA, United States2009
    Universität Konstanz, Konstanz, GermanyM.Sc2001Biology

    Collapse Overview 
    Collapse overview

    Dr. Nündel’s research interest is in understanding how the balance between self – non-self recognition is achieved in the immune system. Currently she is investigating the role of nucleic acid sensing TLRs in B cell tolerance, survival, differentiation and migration. Her in vitro studies on autoreactive B cells are accompanied by studying the mechanisms of B cell activation and migration by self-antigens in mouse models of Systemic Lupus Erythematosus (SLE). Dr. Nündel’s work on B cell migration in SLE is currently funded by a grant from the Lupus Research Alliance, in which she is testing already approved cancer treatments to decrease end-organ damage by inhibiting B cell migration.



    Collapse Research 
    Collapse research activities and funding
         Sep 1, 2016 - Aug 31, 2019
    Lupus Research Alliance
    TLR9 regulates Axl dependent migration of autoreactive B cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pawaria S, Nündel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. Role of Interferon-?-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency. Arthritis Rheumatol. 2020 02; 72(2):359-370. PMID: 31464028.
      Citations: 5     Fields:    Translation:AnimalsCells
    2. Nündel K, Marshak-Rothstein A. The role of nucleic acid sensors and type I IFNs in patient populations and animal models of autoinflammation. Curr Opin Immunol. 2019 12; 61:74-79. PMID: 31569013.
      Citations: 1     Fields:    Translation:HumansAnimals
    3. Nündel K, Mande P, Moses SL, Busto P, Cullen JL, Schmidt MR, Shlomchik MJ, Woodland RT, Marshak-Rothstein A. Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 V?8 B Cells. J Immunol. 2019 Sep 18. PMID: 31534009.
      Citations:    Fields:    
    4. Sindhava VJ, Oropallo MA, Moody K, Naradikian M, Higdon LE, Zhou L, Myles A, Green N, Nündel K, Stohl W, Schmidt AM, Cao W, Dorta-Estremera S, Kambayashi T, Marshak-Rothstein A, Cancro MP. A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest. 2017 May 01; 127(5):1651-1663. PMID: 28346226.
      Citations: 34     Fields:    Translation:AnimalsCells
    5. Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol. 2017 01; 101(1):121-126. PMID: 27531928.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    6. Bossaller L, Christ A, Pelka K, Nündel K, Chiang PI, Pang C, Mishra N, Busto P, Bonegio RG, Schmidt RE, Latz E, Marshak-Rothstein A. TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus. J Immunol. 2016 08 15; 197(4):1044-53. PMID: 27354219.
      Citations: 22     Fields:    Translation:AnimalsCells
    7. Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol. 2016 Feb 01; 196(3):1348-54. PMID: 26729810.
      Citations: 7     Fields:    Translation:AnimalsCells
    8. Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S70-3. PMID: 26457825.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Nündel K, Green NM, Shaffer AL, Moody KL, Busto P, Eilat D, Miyake K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses. J Immunol. 2015 Mar 15; 194(6):2504-12. PMID: 25681333.
      Citations: 33     Fields:    Translation:AnimalsCells
    10. Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E710-7. PMID: 25646421.
      Citations: 75     Fields:    Translation:AnimalsCells
    11. Pawaria S, Moody K, Busto P, Nündel K, Choi CH, Ghayur T, Marshak-Rothstein A. Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. J Immunol. 2015 Feb 15; 194(4):1403-7. PMID: 25601924.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    12. Nündel K, Busto P, Debatis M, Marshak-Rothstein A. The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells. J Leukoc Biol. 2013 Nov; 94(5):865-75. PMID: 23804807.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306. PMID: 23291967.
      Citations: 27     Fields:    Translation:AnimalsCells
    14. Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biol. 2012 May; 90(5):498-504. PMID: 22430248.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    15. Oropallo MA, Kiefer K, Marshak-Rothstein A, Cancro MP. Beyond transitional selection: New roles for BLyS in peripheral tolerance. Drug Dev Res. 2011 Dec; 72(8):779-787. PMID: 22323842.
      Citations: 3     Fields:    
    16. Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity. 2010 Feb; 43(1):103-10. PMID: 20014975.
      Citations: 25     Fields:    Translation:AnimalsCells
    17. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 01; 183(3):1569-76. PMID: 19587008.
      Citations: 62     Fields:    Translation:AnimalsCells
    18. Nakajima PB, Kiefer K, Price A, Bosma GC, Bosma MJ. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol. 2009 Mar 15; 182(6):3583-96. PMID: 19265137.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Kiefer K, Nakajima PB, Oshinsky J, Seeholzer SH, Radic M, Bosma GC, Bosma MJ. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol. 2008 May 01; 180(9):6094-106. PMID: 18424731.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Kiefer K, Oshinsky J, Kim J, Nakajima PB, Bosma GC, Bosma MJ. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2843-8. PMID: 17296939.
      Citations: 13     Fields:    Translation:AnimalsCells
    21. Bosma GC, Oshinsky J, Kiefer K, Nakajima PB, Charan D, Congelton C, Radic M, Bosma MJ. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol. 2006 Jan 15; 176(2):889-98. PMID: 16393973.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Loza MJ, Luppi P, Kiefer K, Martin ES, Szczytkowski JL, Perussia B. Human peripheral CD2-/lo T cells: an extrathymic population of early differentiated, developing T cells. Int Immunol. 2005 Sep; 17(9):1213-25. PMID: 16027135.
      Citations: 3     Fields:    Translation:HumansCells
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