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Kerstin Nundel PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
55 Lake Avenue North LRB 240B
Worcester MA 01655
Phone508-856-8588
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionRheumatology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program


    Collapse Biography 
    Collapse education and training
    Thomas Jefferson University, Philadelphia, PA, United StatesPHDImmunology
    University of Massachusetts Medical School, Worcester, MA, United States2013
    Boston University , Boston, MA, United States2009
    Universit├Ąt Konstanz, Konstanz, GermanyM.Sc2001Biology

    Collapse Overview 
    Collapse overview

    Dr. Nündel’s research interest is in understanding how the balance between self – non-self recognition is achieved in the immune system. Currently she is investigating the role of nucleic acid sensing TLRs in B cell tolerance, survival, differentiation and migration. Her in vitro studies on autoreactive B cells are accompanied by studying the mechanisms of B cell activation and migration by self-antigens in mouse models of Systemic Lupus Erythematosus (SLE). Dr. Nündel’s work on B cell migration in SLE is currently funded by a grant from the Lupus Research Alliance, in which she is testing already approved cancer treatments to decrease end-organ damage by inhibiting B cell migration.



    Collapse Research 
    Collapse research activities and funding
         Sep 1, 2016 - Aug 31, 2019
    Lupus Research Alliance
    TLR9 regulates Axl dependent migration of autoreactive B cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ?akan E, Ah Kioon MD, Garcia-Carmona Y, Glauzy S, Oliver D, Yamakawa N, Vega Loza A, Du Y, Schickel JN, Boeckers JM, Yang C, Baldo A, Ivashkiv LB, Young RM, Staudt LM, Moody KL, N?ndel K, Marshak-Rothstein A, van der Made CI, Hoischen A, Hayward A, Rossato M, Radstake TRDJ, Cunningham-Rundles C, Ryu C, Herzog EL, Barrat FJ, Meffre E. TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance. J Exp Med. 2023 12 04; 220(12). PMID: 37773045.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Gao KM, N?ndel K, Chiang K, Yin X, Utz PJ, Fitzgerald K, Marshak-Rothstein A. Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells. bioRxiv. 2023 Jul 28. PMID: 37546720.
      Citations:    
    3. Stavre Z, Kim JM, Yang YS, N?ndel K, Chaugule S, Sato T, Park KH, Gao G, Gravallese EM, Shim JH. Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2218019120. PMID: 37141171.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Abboud G, Choi SC, Zhang X, Park YP, Kanda N, Zeumer-Spataro L, Terrell M, Teng X, N?ndel K, Shlomchik MJ, Morel L. Glucose Requirement of Antigen-Specific Autoreactive B Cells and CD4+ T Cells. J Immunol. 2023 02 15; 210(4):377-388. PMID: 36602759.
      Citations:    Fields:    Translation:AnimalsCells
    5. Nandakumar KS, N?ndel K. Editorial: Systemic lupus erythematosus - predisposition factors, pathogenesis, diagnosis, treatment and disease models. Front Immunol. 2022; 13:1118180. PMID: 36591294.
      Citations: 2     Fields:    
    6. Gao KM, Derr AG, Guo Z, N?ndel K, Marshak-Rothstein A, Finberg RW, Wang JP. Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2. JCI Insight. 2021 11 22; 6(22). PMID: 34618691.
      Citations: 9     Fields:    Translation:HumansCells
    7. Pellerin A, Yasuda K, Cohen-Bucay A, Sandra V, Shukla P, Jr BKH, N?ndel K, Viglianti GA, Xie Y, Klein U, Tan Y, Bonegio RG, Rifkin IR. Monoallelic IRF5 deficiency in B cells prevents murine lupus. JCI Insight. 2021 08 09; 6(15). PMID: 34197340.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Pawaria S, N?ndel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. Role of Interferon-?-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency. Arthritis Rheumatol. 2020 02; 72(2):359-370. PMID: 31464028.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. N?ndel K, Mande P, Moses SL, Busto P, Cullen JL, Schmidt MR, Shlomchik MJ, Woodland RT, Marshak-Rothstein A. Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 V?8 B Cells. J Immunol. 2019 Oct 15; 203(8):2055-2062. PMID: 31534009.
      Citations:    Fields:    
    10. N?ndel K, Marshak-Rothstein A. The role of nucleic acid sensors and type I IFNs in patient populations and animal models of autoinflammation. Curr Opin Immunol. 2019 12; 61:74-79. PMID: 31569013.
      Citations: 3     Fields:    Translation:HumansAnimals
    11. Sindhava VJ, Oropallo MA, Moody K, Naradikian M, Higdon LE, Zhou L, Myles A, Green N, N?ndel K, Stohl W, Schmidt AM, Cao W, Dorta-Estremera S, Kambayashi T, Marshak-Rothstein A, Cancro MP. A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest. 2017 May 01; 127(5):1651-1663. PMID: 28346226.
      Citations: 44     Fields:    Translation:AnimalsCells
    12. Pawaria S, Sharma S, Baum R, N?ndel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol. 2017 01; 101(1):121-126. PMID: 27531928.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    13. Bossaller L, Christ A, Pelka K, N?ndel K, Chiang PI, Pang C, Mishra N, Busto P, Bonegio RG, Schmidt RE, Latz E, Marshak-Rothstein A. TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus. J Immunol. 2016 08 15; 197(4):1044-53. PMID: 27354219.
      Citations: 31     Fields:    Translation:AnimalsCells
    14. Baum R, N?ndel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol. 2016 Feb 01; 196(3):1348-54. PMID: 26729810.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Pawaria S, Moody KL, Busto P, N?ndel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S70-3. PMID: 26457825.
      Citations: 3     Fields:    Translation:AnimalsCells
    16. N?ndel K, Green NM, Shaffer AL, Moody KL, Busto P, Eilat D, Miyake K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses. J Immunol. 2015 Mar 15; 194(6):2504-12. PMID: 25681333.
      Citations: 39     Fields:    Translation:AnimalsCells
    17. Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, N?ndel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E710-7. PMID: 25646421.
      Citations: 84     Fields:    Translation:AnimalsCells
    18. Pawaria S, Moody K, Busto P, N?ndel K, Choi CH, Ghayur T, Marshak-Rothstein A. Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. J Immunol. 2015 Feb 15; 194(4):1403-7. PMID: 25601924.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    19. N?ndel K, Busto P, Debatis M, Marshak-Rothstein A. The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells. J Leukoc Biol. 2013 Nov; 94(5):865-75. PMID: 23804807.
      Citations: 10     Fields:    Translation:AnimalsCells
    20. Yasuda K, N?ndel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306. PMID: 23291967.
      Citations: 30     Fields:    Translation:AnimalsCells
    21. Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biol. 2012 May; 90(5):498-504. PMID: 22430248.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    22. Oropallo MA, Kiefer K, Marshak-Rothstein A, Cancro MP. Beyond transitional selection: New roles for BLyS in peripheral tolerance. Drug Dev Res. 2011 Dec; 72(8):779-787. PMID: 22323842.
      Citations: 3     Fields:    
    23. Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity. 2010 Feb; 43(1):103-10. PMID: 20014975.
      Citations: 27     Fields:    Translation:AnimalsCells
    24. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 01; 183(3):1569-76. PMID: 19587008.
      Citations: 73     Fields:    Translation:AnimalsCells
    25. Nakajima PB, Kiefer K, Price A, Bosma GC, Bosma MJ. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol. 2009 Mar 15; 182(6):3583-96. PMID: 19265137.
      Citations: 6     Fields:    Translation:AnimalsCells
    26. Kiefer K, Nakajima PB, Oshinsky J, Seeholzer SH, Radic M, Bosma GC, Bosma MJ. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol. 2008 May 01; 180(9):6094-106. PMID: 18424731.
      Citations: 12     Fields:    Translation:AnimalsCells
    27. Kiefer K, Oshinsky J, Kim J, Nakajima PB, Bosma GC, Bosma MJ. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2843-8. PMID: 17296939.
      Citations: 13     Fields:    Translation:AnimalsCells
    28. Bosma GC, Oshinsky J, Kiefer K, Nakajima PB, Charan D, Congelton C, Radic M, Bosma MJ. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol. 2006 Jan 15; 176(2):889-98. PMID: 16393973.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Loza MJ, Luppi P, Kiefer K, Martin ES, Szczytkowski JL, Perussia B. Human peripheral CD2-/lo T cells: an extrathymic population of early differentiated, developing T cells. Int Immunol. 2005 Sep; 17(9):1213-25. PMID: 16027135.
      Citations: 5     Fields:    Translation:HumansCells
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