Nucleoside-Triphosphatase

"Nucleoside-Triphosphatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme which catalyzes the hydrolysis of nucleoside triphosphates to nucleoside diphosphates. It may also catalyze the hydrolysis of nucleotide triphosphates, diphosphates, thiamine diphosphates and FAD. The nucleoside triphosphate phosphohydrolases I and II are subtypes of the enzyme which are found mostly in viruses.

Descriptor ID	D043583
MeSH Number(s)	D08.811.277.040.465
Concept/Terms	Nucleoside-Triphosphatase Nucleoside-Triphosphatase Nucleosidetriphosphatase Nucleoside Triphosphate Phosphohydrolase Phosphohydrolase, Nucleoside Triphosphate Triphosphate Phosphohydrolase, Nucleoside NTPase Nucleoside Triphosphatase Triphosphatase, Nucleoside Nucleoside Triphosphate Phosphohydrolase II Nucleoside Triphosphate Phosphohydrolase II Nucleoside Triphosphate Phosphohydrolase I Nucleoside Triphosphate Phosphohydrolase I

Below are MeSH descriptors whose meaning is more general than "Nucleoside-Triphosphatase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Nucleoside-Triphosphatase [D08.811.277.040.465]

Below are MeSH descriptors whose meaning is related to "Nucleoside-Triphosphatase".

Below are MeSH descriptors whose meaning is more specific than "Nucleoside-Triphosphatase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nucleoside-Triphosphatase" by people in this website by year, and whether "Nucleoside-Triphosphatase" was a major or minor topic of these publications.

Bar chart showing 22 publications over 18 distinct years, with a maximum of 2 publications in 2002 and 2013 and 2016 and 2020

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1998	1	1
2002	2	2
2003	1	1
2005	1	1
2007	1	1
2009	1	1
2010	1	1
2011	1	1
2012	1	1
2013	2	2
2014	1	1
2015	1	1
2016	2	2
2017	1	1
2018	1	1
2020	2	2
2025	1	1
2026	1	1

Below are the most recent publications written about "Nucleoside-Triphosphatase" by people in Profiles.

Gonçalves-Pereira MH, Queiroz-Glauss C, Figueiredo MM, Quintino-de-Carvalho IL, Ramos MF, Bento GA, Magalhães TVB, Mafra AA, Diniz LMO, Costa ÚLD, Gollob KJ, Nogueira ML, Antonelli LRDV, Santiago HDC. DENV-Specific IL-10-Producing Regulatory T Cells Are Associated With Mild Clinical Outcomes in Dengue. J Med Virol. 2026 May; 98(5):e70956.

View in: PubMed
Smith AJ, Rahat MA, Scaramozza LJ, Eyles SJ, Hardy JA. Inhibition of Zika Virus Protease by Modulating NS2B-NS3 Interactions. Biochemistry. 2026 01 06; 65(1):64-76.

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Gonçalves Pereira MH, Figueiredo MM, Queiroz CP, Magalhães TVB, Mafra A, Diniz LMO, da Costa ÚL, Gollob KJ, Antonelli LRDV, Santiago HDC. T-cells producing multiple combinations of IFN?, TNF and IL10 are associated with mild forms of dengue infection. Immunology. 2020 05; 160(1):90-102.

View in: PubMed
Matthew AN, Zephyr J, Nageswara Rao D, Henes M, Kamran W, Kosovrasti K, Hedger AK, Lockbaum GJ, Timm J, Ali A, Kurt Yilmaz N, Schiffer CA. Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors. mBio. 2020 03 31; 11(2).

View in: PubMed
Matthew AN, Leidner F, Newton A, Petropoulos CJ, Huang W, Ali A, KurtYilmaz N, Schiffer CA. Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease. Structure. 2018 10 02; 26(10):1360-1372.e5.

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Matthew AN, Zephyr J, Hill CJ, Jahangir M, Newton A, Petropoulos CJ, Huang W, Kurt-Yilmaz N, Schiffer CA, Ali A. Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants. J Med Chem. 2017 07 13; 60(13):5699-5716.

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Soumana DI, Kurt Yilmaz N, Ali A, Prachanronarong KL, Schiffer CA. Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease. J Am Chem Soc. 2016 09 14; 138(36):11850-9.

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Soumana DI, Kurt Yilmaz N, Prachanronarong KL, Aydin C, Ali A, Schiffer CA. Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172. ACS Chem Biol. 2016 Apr 15; 11(4):900-9.

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Ndjomou J, Corby MJ, Sweeney NL, Hanson AM, Aydin C, Ali A, Schiffer CA, Li K, Frankowski KJ, Schoenen FJ, Frick DN. Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy. ACS Chem Biol. 2015 Aug 21; 10(8):1887-96.

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Soumana DI, Ali A, Schiffer CA. Structural analysis of asunaprevir resistance in HCV NS3/4A protease. ACS Chem Biol. 2014 Nov 21; 9(11):2485-90.

View in: PubMed

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