"Withanolides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.
| Descriptor ID |
D054358
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| MeSH Number(s) |
D04.210.500.247.222.537.888 D04.210.500.247.808.756.904 D10.570.938.795.904 D23.704.500.904
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Withanolides".
Below are MeSH descriptors whose meaning is more specific than "Withanolides".
This graph shows the total number of publications written about "Withanolides" by people in this website by year, and whether "Withanolides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Withanolides" by people in Profiles.
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Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Physalactone and 4?-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. J Nat Prod. 2019 03 22; 82(3):492-499.
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Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4?-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 06; 60(6):1482-500.
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Sang-Ngern M, Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Wall MM, Ruf M, Lorch SE, Leong E, Pezzuto JM, Chang LC. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. Bioorg Med Chem Lett. 2016 Jun 15; 26(12):2755-2759.
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Garc?a ME, Nicotra VE, Oberti JC, R?os-Luci C, Le?n LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padr?n JM, Hueso-Falc?n I, Est?vez-Braun A. Antiproliferative and quinone reductase-inducing activities of withanolides derivatives. Eur J Med Chem. 2014 Jul 23; 82:68-81.
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Youn UJ, Chai X, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Mirza B, Pezzuto JM, Chang LC. Biologically active withanolides from Withania coagulans. J Nat Prod. 2013 Jan 25; 76(1):22-8.