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Robert Kotin to Dependovirus

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This is a "connection" page, showing publications Robert Kotin has written about Dependovirus.
Robert Kotin
Connection Strength
6.475
Dependovirus
  1. Kotin RM, Wright JF. Recombinant Adeno-Associated Virus Quality Control for Non-Clinical and Clinical Vectors: How an Unregulated Commercial Sector Can Compromise Development of New Gene Therapies. Hum Gene Ther. 2019 12; 30(12):1447-1448.
    View in: PubMed
    Score: 0.406
  2. Kotin RM, Snyder RO. Manufacturing Clinical Grade Recombinant Adeno-Associated Virus Using Invertebrate Cell Lines. Hum Gene Ther. 2017 04; 28(4):350-360.
    View in: PubMed
    Score: 0.337
  3. Li L, Dimitriadis EK, Yang Y, Li J, Yuan Z, Qiao C, Beley C, Smith RH, Garcia L, Kotin RM. Production and characterization of novel recombinant adeno-associated virus replicative-form genomes: a eukaryotic source of DNA for gene transfer. PLoS One. 2013; 8(8):e69879.
    View in: PubMed
    Score: 0.262
  4. Barbash IM, Cecchini S, Faranesh AZ, Virag T, Li L, Yang Y, Hoyt RF, Kornegay JN, Bogan JR, Garcia L, Lederman RJ, Kotin RM. MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Ther. 2013 Mar; 20(3):274-82.
    View in: PubMed
    Score: 0.240
  5. Cecchini S, Virag T, Kotin RM. Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures. Hum Gene Ther. 2011 Aug; 22(8):1021-30.
    View in: PubMed
    Score: 0.224
  6. Kotin RM. Large-scale recombinant adeno-associated virus production. Hum Mol Genet. 2011 Apr 15; 20(R1):R2-6.
    View in: PubMed
    Score: 0.223
  7. Virag T, Cecchini S, Kotin RM. Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy. Hum Gene Ther. 2009 Aug; 20(8):807-17.
    View in: PubMed
    Score: 0.198
  8. Smith RH, Levy JR, Kotin RM. A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Mol Ther. 2009 Nov; 17(11):1888-96.
    View in: PubMed
    Score: 0.197
  9. Negrete A, Kotin RM. Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology. Brief Funct Genomic Proteomic. 2008 Jul; 7(4):303-11.
    View in: PubMed
    Score: 0.184
  10. Cecchini S, Negrete A, Kotin RM. Toward exascale production of recombinant adeno-associated virus for gene transfer applications. Gene Ther. 2008 Jun; 15(11):823-30.
    View in: PubMed
    Score: 0.181
  11. Smith RH, Yang L, Kotin RM. Chromatography-based purification of adeno-associated virus. Methods Mol Biol. 2008; 434:37-54.
    View in: PubMed
    Score: 0.178
  12. Negrete A, Kotin RM. Large-scale production of recombinant adeno-associated viral vectors. Methods Mol Biol. 2008; 433:79-96.
    View in: PubMed
    Score: 0.178
  13. Negrete A, Esteban G, Kotin RM. Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy. Appl Microbiol Biotechnol. 2007 Sep; 76(4):761-72.
    View in: PubMed
    Score: 0.173
  14. Negrete A, Kotin RM. Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales. J Virol Methods. 2007 Nov; 145(2):155-61.
    View in: PubMed
    Score: 0.172
  15. Li L, Yang L, Scudiero DA, Miller SA, Yu ZX, Stukenberg PT, Shoemaker RH, Kotin RM. Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells. Gene Ther. 2007 May; 14(10):814-27.
    View in: PubMed
    Score: 0.168
  16. Li L, Yang L, Kotin RM. The DNA minor groove binding agents Hoechst 33258 and 33342 enhance recombinant adeno-associated virus (rAAV) transgene expression. J Gene Med. 2005 Apr; 7(4):420-31.
    View in: PubMed
    Score: 0.147
  17. Smith RH, Ding C, Kotin RM. Serum-free production and column purification of adeno-associated virus type 5. J Virol Methods. 2003 Dec; 114(2):115-24.
    View in: PubMed
    Score: 0.134
  18. Urabe M, Ding C, Kotin RM. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther. 2002 Nov 01; 13(16):1935-43.
    View in: PubMed
    Score: 0.124
  19. Smith RH, Afione SA, Kotin RM. Transposase-mediated construction of an integrated adeno-associated virus type 5 helper plasmid. Biotechniques. 2002 Jul; 33(1):204-6, 208, 210-1.
    View in: PubMed
    Score: 0.121
  20. Schmidt M, Chiorini JA, Afione S, Kotin R. Adeno-associated virus type 2 Rep78 inhibition of PKA and PRKX: fine mapping and analysis of mechanism. J Virol. 2002 Feb; 76(3):1033-42.
    View in: PubMed
    Score: 0.118
  21. Schmidt M, Afione S, Kotin RM. Adeno-associated virus type 2 Rep78 induces apoptosis through caspase activation independently of p53. J Virol. 2000 Oct; 74(20):9441-50.
    View in: PubMed
    Score: 0.108
  22. Yang YW, Kotin RM. Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors. Pharm Res. 2000 Sep; 17(9):1056-61.
    View in: PubMed
    Score: 0.107
  23. Smith RH, Kotin RM. An adeno-associated virus (AAV) initiator protein, Rep78, catalyzes the cleavage and ligation of single-stranded AAV ori DNA. J Virol. 2000 Apr; 74(7):3122-9.
    View in: PubMed
    Score: 0.104
  24. Chiorini JA, Afione S, Kotin RM. Adeno-associated virus (AAV) type 5 Rep protein cleaves a unique terminal resolution site compared with other AAV serotypes. J Virol. 1999 May; 73(5):4293-8.
    View in: PubMed
    Score: 0.097
  25. Chiorini JA, Kim F, Yang L, Kotin RM. Cloning and characterization of adeno-associated virus type 5. J Virol. 1999 Feb; 73(2):1309-19.
    View in: PubMed
    Score: 0.096
  26. Chiorini JA, Zimmermann B, Yang L, Smith RH, Ahearn A, Herberg F, Kotin RM. Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2. Mol Cell Biol. 1998 Oct; 18(10):5921-9.
    View in: PubMed
    Score: 0.094
  27. Smith RH, Kotin RM. The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity. J Virol. 1998 Jun; 72(6):4874-81.
    View in: PubMed
    Score: 0.091
  28. Chiorini JA, Yang L, Liu Y, Safer B, Kotin RM. Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol. 1997 Sep; 71(9):6823-33.
    View in: PubMed
    Score: 0.087
  29. Smith RH, Spano AJ, Kotin RM. The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences. J Virol. 1997 Jun; 71(6):4461-71.
    View in: PubMed
    Score: 0.085
  30. Smith RH, Hallwirth CV, Westerman M, Hetherington NA, Tseng YS, Cecchini S, Virag T, Ziegler ML, Rogozin IB, Koonin EV, Agbandje-McKenna M, Kotin RM, Alexander IE. Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Sci Rep. 2016 07 05; 6:28965.
    View in: PubMed
    Score: 0.080
  31. Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA, Kotin RM, Martin DR, Sena-Esteves M. In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. Mol Ther. 2016 08; 24(7):1247-57.
    View in: PubMed
    Score: 0.079
  32. Chiorini JA, Wiener SM, Yang L, Smith RH, Safer B, Kilcoin NP, Liu Y, Urcelay E, Kotin RM. The roles of AAV Rep proteins in gene expression and targeted integration. Curr Top Microbiol Immunol. 1996; 218:25-33.
    View in: PubMed
    Score: 0.077
  33. Chiorini JA, Wendtner CM, Urcelay E, Safer B, Hallek M, Kotin RM. High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors. Hum Gene Ther. 1995 Dec; 6(12):1531-41.
    View in: PubMed
    Score: 0.077
  34. Chiorini JA, Yang L, Safer B, Kotin RM. Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection. J Virol. 1995 Nov; 69(11):7334-8.
    View in: PubMed
    Score: 0.076
  35. Urcelay E, Ward P, Wiener SM, Safer B, Kotin RM. Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein. J Virol. 1995 Apr; 69(4):2038-46.
    View in: PubMed
    Score: 0.073
  36. Le Guiner C, Montus M, Servais L, Cherel Y, Francois V, Thibaud JL, Wary C, Matot B, Larcher T, Guigand L, Dutilleul M, Domenger C, Allais M, Beuvin M, Moraux A, Le Duff J, Devaux M, Jaulin N, Guilbaud M, Latournerie V, Veron P, Boutin S, Leborgne C, Desgue D, Deschamps JY, Moullec S, Fromes Y, Vulin A, Smith RH, Laroudie N, Barnay-Toutain F, Rivi?re C, Bucher S, Le TH, Delaunay N, Gasmi M, Kotin RM, Bonne G, Adjali O, Masurier C, Hogrel JY, Carlier P, Moullier P, Voit T. Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients. Mol Ther. 2014 Nov; 22(11):1923-35.
    View in: PubMed
    Score: 0.070
  37. Kotin RM. Prospects for the use of adeno-associated virus as a vector for human gene therapy. Hum Gene Ther. 1994 Jul; 5(7):793-801.
    View in: PubMed
    Score: 0.070
  38. Chiorini JA, Weitzman MD, Owens RA, Urcelay E, Safer B, Kotin RM. Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. J Virol. 1994 Feb; 68(2):797-804.
    View in: PubMed
    Score: 0.068
  39. Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J. 1992 Dec; 11(13):5071-8.
    View in: PubMed
    Score: 0.062
  40. Denard J, Beley C, Kotin R, Lai-Kuen R, Blot S, Leh H, Asokan A, Samulski RJ, Moullier P, Voit T, Garcia L, Svinartchouk F. Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6. J Virol. 2012 Jun; 86(12):6620-31.
    View in: PubMed
    Score: 0.060
  41. H?ndel EM, Gellhaus K, Khan K, Bednarski C, Cornu TI, M?ller-Lerch F, Kotin RM, Heilbronn R, Cathomen T. Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors. Hum Gene Ther. 2012 Mar; 23(3):321-9.
    View in: PubMed
    Score: 0.058
  42. Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin A, Beley C, Bogan J, Wilson JM, Vandenborne K, Kornegay JN, Walter GA, Kotin RM, Garcia L, Sweeney HL. Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping. Mol Ther. 2012 Mar; 20(3):580-9.
    View in: PubMed
    Score: 0.058
  43. Kotin RM, Menninger JC, Ward DC, Berns KI. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics. 1991 Jul; 10(3):831-4.
    View in: PubMed
    Score: 0.057
  44. Kotin RM, Siniscalco M, Samulski RJ, Zhu XD, Hunter L, Laughlin CA, McLaughlin S, Muzyczka N, Rocchi M, Berns KI. Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2211-5.
    View in: PubMed
    Score: 0.052
  45. Kotin RM, Berns KI. Organization of adeno-associated virus DNA in latently infected Detroit 6 cells. Virology. 1989 Jun; 170(2):460-7.
    View in: PubMed
    Score: 0.049
  46. Szerlip NJ, Walbridge S, Yang L, Morrison PF, Degen JW, Jarrell ST, Kouri J, Kerr PB, Kotin R, Oldfield EH, Lonser RR. Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles. J Neurosurg. 2007 Sep; 107(3):560-7.
    View in: PubMed
    Score: 0.043
  47. Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R, Kotin RM, L?nning PE, Hoover F. Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. J Gene Med. 2006 Sep; 8(9):1131-40.
    View in: PubMed
    Score: 0.041
  48. Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K. Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells. J Virol. 2006 Feb; 80(4):1874-85.
    View in: PubMed
    Score: 0.039
  49. Huszthy PC, Svendsen A, Wilson JM, Kotin RM, L?nning PE, Bjerkvig R, Hoover F. Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts. Hum Gene Ther. 2005 Mar; 16(3):381-92.
    View in: PubMed
    Score: 0.036
  50. Hickman AB, Ronning DR, Perez ZN, Kotin RM, Dyda F. The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol Cell. 2004 Feb 13; 13(3):403-14.
    View in: PubMed
    Score: 0.034
  51. Lotery AJ, Yang GS, Mullins RF, Russell SR, Schmidt M, Stone EM, Lindbloom JD, Chiorini JA, Kotin RM, Davidson BL. Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina. Hum Gene Ther. 2003 Nov 20; 14(17):1663-71.
    View in: PubMed
    Score: 0.033
  52. Yang GS, Schmidt M, Yan Z, Lindbloom JD, Harding TC, Donahue BA, Engelhardt JF, Kotin R, Davidson BL. Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. J Virol. 2002 Aug; 76(15):7651-60.
    View in: PubMed
    Score: 0.031
  53. Mastakov MY, Baer K, Symes CW, Leichtlein CB, Kotin RM, During MJ. Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. J Virol. 2002 Aug; 76(16):8446-54.
    View in: PubMed
    Score: 0.031
  54. Hickman AB, Ronning DR, Kotin RM, Dyda F. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol Cell. 2002 Aug; 10(2):327-37.
    View in: PubMed
    Score: 0.031
  55. Mastakov MY, Baer K, Kotin RM, During MJ. Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion. Mol Ther. 2002 Apr; 5(4):371-80.
    View in: PubMed
    Score: 0.030
  56. Yamano S, Huang LY, Ding C, Chiorini JA, Goldsmith CM, Wellner RB, Golding B, Kotin RM, Scott DE, Baum BJ. Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream. Hum Gene Ther. 2002 Jan 20; 13(2):287-98.
    View in: PubMed
    Score: 0.029
  57. Zabner J, Seiler M, Walters R, Kotin RM, Fulgeras W, Davidson BL, Chiorini JA. Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. J Virol. 2000 Apr; 74(8):3852-8.
    View in: PubMed
    Score: 0.026
  58. Davidson BL, Stein CS, Heth JA, Martins I, Kotin RM, Derksen TA, Zabner J, Ghodsi A, Chiorini JA. Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3428-32.
    View in: PubMed
    Score: 0.026
  59. Braddon VR, Chiorini JA, Wang S, Kotin RM, Baum BJ. Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo. Hum Gene Ther. 1998 Dec 10; 9(18):2777-85.
    View in: PubMed
    Score: 0.024
  60. Maass G, Bogedain C, Scheer U, Michl D, H?rer M, Braun-Falco M, Volkenandt M, Schadendorf D, Wendtner CM, Winnacker EL, Kotin RM, Hallek M. Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells. Hum Gene Ther. 1998 May 01; 9(7):1049-59.
    View in: PubMed
    Score: 0.023
  61. Chiorini JA, Wiener SM, Owens RA, Ky?sti? SR, Kotin RM, Safer B. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. J Virol. 1994 Nov; 68(11):7448-57.
    View in: PubMed
    Score: 0.018
  62. Batchu RB, Kotin RM, Hermonat PL. The regulatory rep protein of adeno-associated virus binds to sequences within the c-H-ras promoter. Cancer Lett. 1994 Oct 28; 86(1):23-31.
    View in: PubMed
    Score: 0.018
  63. Ward P, Urcelay E, Kotin R, Safer B, Berns KI. Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein. J Virol. 1994 Sep; 68(9):6029-37.
    View in: PubMed
    Score: 0.018
  64. Weitzman MD, Ky?sti? SR, Kotin RM, Owens RA. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):5808-12.
    View in: PubMed
    Score: 0.017
  65. Berns KI, Kotin RM, Labow MA. Regulation of adeno-associated virus DNA replication. Biochim Biophys Acta. 1988 Dec 20; 951(2-3):425-9.
    View in: PubMed
    Score: 0.012
  66. Hsu PY, Kotin RM, Yang YW. Glucose- and metabolically regulated hepatic insulin gene therapy for diabetes. Pharm Res. 2008 Jun; 25(6):1460-8.
    View in: PubMed
    Score: 0.011
  67. Wendtner CM, Nolte A, Mangold E, Buhmann R, Maass G, Chiorini JA, Winnacker EL, Emmerich B, Kotin RM, Hallek M. Gene transfer of the costimulatory molecules B7-1 and B7-2 into human multiple myeloma cells by recombinant adeno-associated virus enhances the cytolytic T cell response. Gene Ther. 1997 Jul; 4(7):726-35.
    View in: PubMed
    Score: 0.005
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