HSC70 Heat-Shock Proteins
"HSC70 Heat-Shock Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A constitutively expressed subfamily of the HSP70 heat-shock proteins. They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION.
| Descriptor ID |
D050883
|
| MeSH Number(s) |
D12.776.580.216.375.200
|
| Concept/Terms |
HSC70 Heat-Shock Proteins- HSC70 Heat-Shock Proteins
- HSC70 Heat Shock Proteins
- Heat-Shock Proteins, HSC70
- Hsc70 Protein
- Heat-Shock Cognate 70 Protein
- Heat Shock Cognate 70 Protein
- Clathrin Uncoating Protein
- Uncoating Protein, Clathrin
- 70 kDa Heat-Shock Cognate Protein
- 70 kDa Heat Shock Cognate Protein
|
Below are MeSH descriptors whose meaning is more general than "HSC70 Heat-Shock Proteins".
Below are MeSH descriptors whose meaning is more specific than "HSC70 Heat-Shock Proteins".
This graph shows the total number of publications written about "HSC70 Heat-Shock Proteins" by people in this website by year, and whether "HSC70 Heat-Shock Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "HSC70 Heat-Shock Proteins" by people in Profiles.
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Bhasne K, Bogoian-Mullen A, Clerico EM, Gierasch LM. The Hsc70 system maintains the synaptic SNARE protein SNAP-25 in an assembly-competent state and delays its aggregation. J Biol Chem. 2024 Dec; 300(12):108001.
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Meng W, Clerico EM, McArthur N, Gierasch LM. Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):11970-11975.
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Vodicka P, Chase K, Iuliano M, Tousley A, Valentine DT, Sapp E, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016 10 01; 5(3):249-260.
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Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49.
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Xing Y, B?cking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65.
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Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53.