"Physostigmine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
| Descriptor ID |
D010830
|
| MeSH Number(s) |
D02.241.081.251.583.682 D03.132.436.545 D03.633.100.473.402.545
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Physostigmine".
Below are MeSH descriptors whose meaning is more specific than "Physostigmine".
This graph shows the total number of publications written about "Physostigmine" by people in this website by year, and whether "Physostigmine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Physostigmine" by people in Profiles.
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Whitledge JD, Watson CJ, Simpson M, Bakkar A, Boussi L, Scott M, Boyle KL. Diphenhydramine-Induced Antimuscarinic Delirium Treated with Physostigmine and Transdermal Rivastigmine. J Med Toxicol. 2023 04; 19(2):219-223.
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Rosenbaum C, Bird SB. Timing and frequency of physostigmine redosing for antimuscarinic toxicity. J Med Toxicol. 2010 Dec; 6(4):386-92.
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Rhyee SH, Pedapati EV, Thompson J. Prolonged delirium after quetiapine overdose. Pediatr Emerg Care. 2010 Oct; 26(10):754-6.
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Hamam BN, Sinai M, Poirier G, Chapman CA. Cholinergic suppression of excitatory synaptic responses in layer II of the medial entorhinal cortex. Hippocampus. 2007; 17(2):103-13.
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Weizberg M, Su M, Mazzola JL, Bird SB, Brush DE, Boyer EW. Altered mental status from olanzapine overdose treated with physostigmine. Clin Toxicol (Phila). 2006; 44(3):319-25.
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Carraway RE, Mitra SP. Binding and biologic activity of neurotensin in guinea pig ileum. Peptides. 1994; 15(8):1451-9.
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Kapen S, Fleming PD, Drachman DA. Cholinergic enhancement and REM sleep latency in the aged: lecithin does not reproduce physostigmine effect. Neurology. 1986 Aug; 36(8):1079-83.
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Drachman DA, Sahakian BJ. Memory and cognitive function in the elderly. A preliminary trial of physostigmine. Arch Neurol. 1980 Oct; 37(10):674-5.
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Drachman DA. Memory and cognitive function in man: does the cholinergic system have a specific role? Neurology. 1977 Aug; 27(8):783-90.
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Drachman DA, Leavitt J. Human memory and the cholinergic system. A relationship to aging? Arch Neurol. 1974 Feb; 30(2):113-21.