"Tacrine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
| Descriptor ID |
D013619
|
| MeSH Number(s) |
D03.633.300.046.250.900
|
| Concept/Terms |
Tacrine- Tacrine
- 9-Amino-1,2,3,4-Tetrahydroacridine
- 1,2,3,4-Tetrahydro-9-acridinamine
- Tetrahydroaminoacridine
- 1,2,3,4-Tetrahydroaminoacridine
|
Below are MeSH descriptors whose meaning is more general than "Tacrine".
Below are MeSH descriptors whose meaning is more specific than "Tacrine".
This graph shows the total number of publications written about "Tacrine" by people in this website by year, and whether "Tacrine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tacrine" by people in Profiles.
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Gasper MC, Ott BR, Lapane KL. Is donepezil therapy associated with reduced mortality in nursing home residents with dementia? Am J Geriatr Pharmacother. 2005 Mar; 3(1):1-7.
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Ott BR, Lapane KL. Tacrine therapy is associated with reduced mortality in nursing home residents with dementia. J Am Geriatr Soc. 2002 Jan; 50(1):35-40.
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Gifford DR, Lapane KL, Gambassi G, Landi F, Mor V, Bernabei R. Tacrine use in nursing homes: implications for prescribing new cholinesterase inhibitors. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. Neurology. 1999 Jan 15; 52(2):238-44.
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Davis KL, Thal LJ, Gamzu ER, Davis CS, Woolson RF, Gracon SI, Drachman DA, Schneider LS, Whitehouse PJ, Hoover TM, et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group. N Engl J Med. 1992 Oct 29; 327(18):1253-9.