Synaptosomal-Associated Protein 25
"Synaptosomal-Associated Protein 25" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitous target SNARE protein that interacts with SYNTAXIN and SYNAPTOBREVIN. It is a core component of the machinery for intracellular MEMBRANE FUSION. The sequence contains 2 SNARE domains, one is the prototype for the Qb-SNARES, and the other is the prototype for the Qc-SNARES.
| Descriptor ID |
D050825
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| MeSH Number(s) |
D12.776.543.512.249.500.750.500 D12.776.543.512.249.500.875.500 D12.776.543.990.775.500.750.500 D12.776.543.990.775.500.875.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synaptosomal-Associated Protein 25".
Below are MeSH descriptors whose meaning is more specific than "Synaptosomal-Associated Protein 25".
This graph shows the total number of publications written about "Synaptosomal-Associated Protein 25" by people in this website by year, and whether "Synaptosomal-Associated Protein 25" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Synaptosomal-Associated Protein 25" by people in Profiles.
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Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE. Disabling the G??-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Sci Signal. 2019 02 19; 12(569).
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Wakai T, Fissore RA. Constitutive IP3R1-mediated Ca2+ release reduces Ca2+ store content and stimulates mitochondrial metabolism in mouse GV oocytes. J Cell Sci. 2019 02 12; 132(3).
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Zulliger R, Conley SM, Mwoyosvi ML, Stuck MW, Azadi S, Naash MI. SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PLoS One. 2015; 10(9):e0138508.
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Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong M. Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun. 2013; 4:1472.
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Smith AK, Mick E, Faraone SV. Advances in genetic studies of attention-deficit/hyperactivity disorder. Curr Psychiatry Rep. 2009 Apr; 11(2):143-8.
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Tomes CN, Michaut M, De Blas G, Visconti P, Matti U, Mayorga LS. SNARE complex assembly is required for human sperm acrosome reaction. Dev Biol. 2002 Mar 15; 243(2):326-38.
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Catsicas S, Catsicas M, Keyser KT, Karten HJ, Wilson MC, Milner RJ. Differential expression of the presynaptic protein SNAP-25 in mammalian retina. J Neurosci Res. 1992 Sep; 33(1):1-9.
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Catsicas S, Larhammar D, Blomqvist A, Sanna PP, Milner RJ, Wilson MC. Expression of a conserved cell-type-specific protein in nerve terminals coincides with synaptogenesis. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):785-9.