Compassionate Use Trials

"Compassionate Use Trials" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Providing an investigational therapy to a patient who is not eligible to receive that therapy in a clinical trial, but who has a serious or life-threatening illness for which other treatments are not available. Compassionate use trials allow patients to receive promising but not yet fully studied or approved therapies when no other treatment option exists. Also called expanded access trial.

Descriptor ID	D057176
MeSH Number(s)	E02.931.500 E05.337.300.199
Concept/Terms	Compassionate Use Trials Compassionate Use Trials Compassionate Use Trial Trial, Compassionate Use Trials, Compassionate Use Use Trials, Compassionate Expanded Access Trials Access Trial, Expanded Expanded Access Trial Trial, Expanded Access Trials, Expanded Access Humanitarian Device Exemption Humanitarian Device Exemption Device Exemption, Humanitarian Device Exemptions, Humanitarian Exemption, Humanitarian Device Exemptions, Humanitarian Device Humanitarian Device Exemptions Compassionate Use Compassionate Use Compassionate Uses Use, Compassionate

Below are MeSH descriptors whose meaning is more general than "Compassionate Use Trials".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Therapies, Investigational [E02.931]
Compassionate Use Trials [E02.931.500]
Investigative Techniques [E05]
Evaluation Studies as Topic [E05.337]
Drug Approval [E05.337.300]
Compassionate Use Trials [E05.337.300.199]

Below are MeSH descriptors whose meaning is related to "Compassionate Use Trials".

Below are MeSH descriptors whose meaning is more specific than "Compassionate Use Trials".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Compassionate Use Trials" by people in this website by year, and whether "Compassionate Use Trials" was a major or minor topic of these publications.

Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 2019 and 2021 and 2026

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2019	1	0	1
2021	0	1	1
2026	0	1	1

Below are the most recent publications written about "Compassionate Use Trials" by people in Profiles.

Hainstock MR, Fleming G, Kim D, Aboulhosn J, Levi D, Krasuski R, Sommer R, Torres AJ, Gray R, Kereiakes D, Leventhal A, Gillespie M, Szeto W, Zajarias A, Shahanavaz S, Steinberg ZL, Jones TK, Mahadevan VS, Moore P, Elmariah S, Shirali G, Li W, Babaliaros V, Lim DS. Five-Year Outcomes for Patients With RVOT Dysfunction Treated With the SAPIEN 3 Transcatheter Heart Valve: A Pooled Analysis From the COMPASSION S3 Trial. Circ Cardiovasc Interv. 2026 May; 19(5):e016361.

View in: PubMed
Basso U, Procopio G, Fornarini G, Massari F, Bearz A, Fratino L, Milella M, Bassanelli M, Ermacora P, Bimbatti D, Verzoni E, Rizzo M, Porta C. Safety and Efficacy of Tivozanib in First-Line mRCC: A Multicenter Compassionate-Use Study (Meet-Uro 16). Oncology. 2021; 99(12):747-755.

View in: PubMed
Lopez-Gomez C, Sanchez-Quintero MJ, Lee EJ, Kleiner G, Tadesse S, Xie J, Akman HO, Gao G, Hirano M. Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency. Ann Neurol. 2021 10; 90(4):640-652.

View in: PubMed
Jankowitz BT, Hanel R, Jadhav AP, Loy DN, Frei D, Siddiqui AH, Puri AS, Khaldi A, Turk AS, Malek AM, Sauvageau E, Hetts SW, Zaidat OO. Neuroform Atlas Stent System for the treatment of intracranial aneurysm: primary results of the Atlas Humanitarian Device Exemption cohort. J Neurointerv Surg. 2019 Aug; 11(8):801-806.

View in: PubMed
Caffo O, De Giorgi U, Fratino L, Lo Re G, Basso U, D'Angelo A, Donini M, Verderame F, Ratta R, Procopio G, Campadelli E, Massari F, Gasparro D, Macrini S, Messina C, Giordano M, Alesini D, Zustovich F, Fraccon AP, Vicario G, Conteduca V, Maines F, Galligioni E. Safety and clinical outcomes of patients treated with abiraterone acetate after docetaxel: results of the Italian Named Patient Programme. BJU Int. 2015 May; 115(5):764-71.

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Weinstein S, Bello R, Pizarro C, Fynn-Thompson F, Kirklin J, Guleserian K, Woods R, Tjossem C, Kroslowitz R, Friedmann P, Jaquiss R. The use of the Berlin Heart EXCOR in patients with functional single ventricle. J Thorac Cardiovasc Surg. 2014 Feb; 147(2):697-704; discussion 704-5.

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Fitzgerald MC, Chan JY, Ross AW, Liew SM, Butt WW, Baguley D, Salem HH, Russ MK, Deasy C, Martin KE, Mathew JK, Rosenfeld JV. A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma. Med J Aust. 2011 May 02; 194(9):471-3.

View in: PubMed

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