Neural Tube Defects

"Neural Tube Defects" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)

Descriptor ID	D009436
MeSH Number(s)	C10.500.680 C16.131.666.680
Concept/Terms	Neural Tube Defects Neural Tube Defects Defect, Neural Tube Defects, Neural Tube Neural Tube Defect Developmental Neural Tube Defects Neural Tube Developmental Defects Developmental Defects, Neural Tube Craniorachischisis Craniorachischisis Craniorachischises Diastematomyelia Diastematomyelia Diastematomyelias Tethered Cord Syndrome Tethered Cord Syndrome Tethered Cord Syndromes Occult Spinal Dysraphism Sequence Tethered Spinal Cord Syndrome Occult Spinal Dysraphism Dysraphism, Occult Spinal Dysraphisms, Occult Spinal Occult Spinal Dysraphisms Spinal Dysraphism, Occult Spinal Dysraphisms, Occult Iniencephaly Iniencephaly Iniencephalies Neurenteric Cyst Neurenteric Cyst Cyst, Neurenteric Cysts, Neurenteric Neurenteric Cysts Neuroenteric Cyst Cyst, Neuroenteric Cysts, Neuroenteric Neuroenteric Cysts Spinal Cord Myelodysplasia Spinal Cord Myelodysplasia Myelodysplasia, Spinal Cord Myelodysplasias, Spinal Cord Spinal Cord Myelodysplasias Acrania Acrania Acranias Exencephaly Exencephaly Exencephalies

Below are MeSH descriptors whose meaning is more general than "Neural Tube Defects".

Diseases [C]
Nervous System Diseases [C10]
Nervous System Malformations [C10.500]
Neural Tube Defects [C10.500.680]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Nervous System Malformations [C16.131.666]
Neural Tube Defects [C16.131.666.680]

Below are MeSH descriptors whose meaning is related to "Neural Tube Defects".

Below are MeSH descriptors whose meaning is more specific than "Neural Tube Defects".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neural Tube Defects" by people in this website by year, and whether "Neural Tube Defects" was a major or minor topic of these publications.

Bar chart showing 26 publications over 17 distinct years, with a maximum of 3 publications in 2009 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2003	2	0	2
2005	1	0	1
2006	1	0	1
2007	1	0	1
2008	1	0	1
2009	1	2	3
2010	1	0	1
2011	3	0	3
2012	0	1	1
2013	2	0	2
2014	1	0	1
2015	1	0	1
2016	0	1	1
2018	1	1	2
2019	1	1	2
2022	2	0	2

Below are the most recent publications written about "Neural Tube Defects" by people in Profiles.

Boudreau DM, Pocobelli G, Bobb JF, Cheetham C, Dublin S, Andrade SE, Albertson-Junkans L, Griffin MR, Li DK, Raebel MA, Hechter RC, Pawloski PA, Toh S, Hua W, Ouellet-Hellstrom R, Horn P, Dinatale M, Ceresa C, Soukup M, Ma Y, Trinidad JP. Neural tube defect risk in relation to opioid analgesic exposure during early pregnancy. Am J Epidemiol. 2026 05 07; 195(5):1242-1251.

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Butler KM, Fee T, DuPont BR, Dean JH, Stevenson RE, Lyons MJ. A SOX3 duplication and lumbosacral spina bifida in three generations. Am J Med Genet A. 2022 05; 188(5):1572-1577.

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Nychyk O, Galea GL, Mol? M, Savery D, Greene NDE, Stanier P, Copp AJ. Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension. Dis Model Mech. 2022 01 01; 15(1).

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Orru E, Tsang COA, Klostranec JM, Pereira VM. Transradial approach in the treatment of a sacral dural arteriovenous fistula: a technical note. BMJ Case Rep. 2019 Mar 31; 12(3).

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Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe K, Cox TC, Hildebrandt F, Apte SS. Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis. Nat Commun. 2019 02 27; 10(1):953.

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De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE. Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice. Hum Mol Genet. 2018 12 15; 27(24):4218-4230.

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Orriss IR, Lanham S, Savery D, Greene NDE, Stanier P, Oreffo R, Copp AJ, Galea GL. Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice. Sci Rep. 2018 02 20; 8(1):3325.

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Hong T, Park JE, Ling F, terBrugge KG, Tymianski M, Zhang HQ, Krings T. Comparison of 3 Different Types of Spinal Arteriovenous Shunts below the Conus in Clinical Presentation, Radiologic Findings, and Outcomes. AJNR Am J Neuroradiol. 2017 Feb; 38(2):403-409.

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Engelberg RB, Roguski M, Riesenburger RI, Do-Dai D, Jea A, Hwang SW. Morphometric analysis of lumbar pedicles in patients with spinal dysraphism. Pediatr Neurosurg. 2015; 50(1):1-6.

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Murdoch JN, Damrau C, Paudyal A, Bogani D, Wells S, Greene ND, Stanier P, Copp AJ. Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice. Dis Model Mech. 2014 Oct; 7(10):1153-63.

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