Lymphoma, Large B-Cell, Diffuse

"Lymphoma, Large B-Cell, Diffuse" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Descriptor ID	D016403
MeSH Number(s)	C04.557.386.480.150.585 C15.604.515.569.480.150.585 C20.683.515.761.480.150.585
Concept/Terms	Lymphoma, Large B-Cell, Diffuse Lymphoma, Large B-Cell, Diffuse Diffuse, Large B-Cell, Lymphoma Histiocytic Lymphoma Histiocytic Lymphomas Lymphomas, Histiocytic Histiocytic Lymphoma, Diffuse Diffuse Histiocytic Lymphoma Diffuse Histiocytic Lymphomas Histiocytic Lymphomas, Diffuse Lymphoma, Diffuse Histiocytic Lymphomas, Diffuse Histiocytic Large Lymphoid Lymphoma, Diffuse Lymphoma, Large-Cell, Diffuse Lymphoma, Diffuse Large-Cell Lymphoma, Diffuse Large Cell Lymphoma, Histiocytic Lymphoma, Large Lymphoid, Diffuse Lymphoma, Histiocytic, Diffuse Lymphoma, Large Cell, Diffuse Diffuse Large-Cell Lymphoma Diffuse Large Cell Lymphoma Diffuse Large-Cell Lymphomas Large-Cell Lymphomas, Diffuse Lymphomas, Diffuse Large-Cell Large-Cell Lymphoma, Diffuse Large Cell Lymphoma, Diffuse

Below are MeSH descriptors whose meaning is more general than "Lymphoma, Large B-Cell, Diffuse".

Diseases [C]
Neoplasms [C04]
Neoplasms by Histologic Type [C04.557]
Lymphoma [C04.557.386]
Lymphoma, Non-Hodgkin [C04.557.386.480]
Lymphoma, B-Cell [C04.557.386.480.150]
Lymphoma, Large B-Cell, Diffuse [C04.557.386.480.150.585]
Hemic and Lymphatic Diseases [C15]
Lymphatic Diseases [C15.604]
Lymphoproliferative Disorders [C15.604.515]
Lymphoma [C15.604.515.569]
Lymphoma, Non-Hodgkin [C15.604.515.569.480]
Lymphoma, B-Cell [C15.604.515.569.480.150]
Lymphoma, Large B-Cell, Diffuse [C15.604.515.569.480.150.585]
Immune System Diseases [C20]
Immunoproliferative Disorders [C20.683]
Lymphoproliferative Disorders [C20.683.515]
Lymphoma [C20.683.515.761]
Lymphoma, Non-Hodgkin [C20.683.515.761.480]
Lymphoma, B-Cell [C20.683.515.761.480.150]
Lymphoma, Large B-Cell, Diffuse [C20.683.515.761.480.150.585]

Below are MeSH descriptors whose meaning is related to "Lymphoma, Large B-Cell, Diffuse".

Below are MeSH descriptors whose meaning is more specific than "Lymphoma, Large B-Cell, Diffuse".

Lymphoma, Large B-Cell, Diffuse
Plasmablastic Lymphoma

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lymphoma, Large B-Cell, Diffuse" by people in this website by year, and whether "Lymphoma, Large B-Cell, Diffuse" was a major or minor topic of these publications.

Bar chart showing 43 publications over 23 distinct years, with a maximum of 5 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
2000	0	1	1
2003	2	0	2
2004	1	0	1
2005	2	0	2
2006	2	0	2
2007	1	0	1
2008	2	0	2
2010	1	0	1
2011	3	0	3
2012	1	0	1
2013	1	0	1
2014	5	0	5
2016	3	0	3
2018	0	1	1
2019	0	1	1
2020	4	0	4
2021	2	0	2
2022	1	0	1
2023	2	0	2
2024	3	1	4
2025	1	0	1

Below are the most recent publications written about "Lymphoma, Large B-Cell, Diffuse" by people in Profiles.

van der Heiden AD, Pensch R, Agger S, Gardner HL, Hendricks W, Zismann V, Wong S, Briones N, Turner B, Forsberg-Nilsson K, London C, Lindblad-Toh K, Arendt ML. Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival. Sci Rep. 2025 Feb 08; 15(1):4724.

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Tringale KR, Scordo M, Yahalom J, White C, Zhang Z, Vachha B, Cederquist G, Schaff L, DeAngelis L, Grommes C, Imber BS. Outcomes and relapse patterns in primary central nervous system lymphoma: Longitudinal analysis of 559 patients diagnosed from 1983 to 2020. Neuro Oncol. 2024 Nov 04; 26(11):2061-2073.

View in: PubMed
Wang TP, Ahn KW, Shadman M, Kaur M, Ahmed N, Bacher U, Cerny J, Chen A, Epperla N, Frigault M, Grover N, Haverkos B, Hill B, Hossain N, Iqbal M, Jain T, Krem MM, Maakaron J, Modi D, Alhaj Moustafa M, Riedell P, Savani B, Sica RA, Sureda A, Wudhikarn K, Herrera AF, Sauter C, Hamadani M, Jimenez Jimenez A. Chimeric antigen receptor T-cell infusion for large B-cell lymphoma in complete remission: a center for international blood and marrow transplant research analysis. Leukemia. 2024 Jul; 38(7):1564-1569.

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McLinden GP, Avery AC, Gardner HL, Hughes K, Rodday AM, Liang K, London CA. Safety and biologic activity of a canine anti-CD20 monoclonal antibody in dogs with diffuse large B-cell lymphoma. J Vet Intern Med. 2024 May-Jun; 38(3):1666-1674.

View in: PubMed
McCrury M, Swafford K, Shuttleworth SL, Mehdi SH, Acharya B, Saha D, Naceanceno K, Byrum SD, Storey AJ, Xu YZ, Doshier C, Patel V, Post GR, De Loose A, Rodriguez A, Shultz LD, Zhan F, Yoon D, Frett B, Kendrick S. Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma. Mol Cancer Ther. 2024 Mar 04; 23(3):316-329.

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Arun Kumar S, Mishra R, Malempati SC, Bindal P. Primary cardiac large B cell lymphoma. BMJ Case Rep. 2023 Dec 26; 16(12).

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Dittrich K, Yildiz-Altay ?, Qutab F, Kwong DA, Rao Z, Nievez-Lozano SA, Gardner HL, Richmond JM, London CA. Baseline tumor gene expression signatures correlate with chemoimmunotherapy treatment responsiveness in canine B cell lymphoma. PLoS One. 2023; 18(8):e0290428.

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Rhee J, Birmann BM, De Roos AJ, Epstein MM, Martinez-Maza O, Breen EC, Magpantay LI, Levin LI, Visvanathan K, Hosgood HD, Rohan TE, Smoller SW, Bassig BA, Qi L, Shu XO, Koh WP, Zheng W, Yuan JM, Weinstein SJ, Albanes D, Lan Q, Rothman N, Purdue MP. Circulating immune markers and risks of non-Hodgkin lymphoma subtypes: A pooled analysis. Int J Cancer. 2023 Mar 01; 152(5):865-878.

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Cherng HJ, Sun R, Sugg B, Irwin R, Yang H, Le CC, Deng Q, Fayad L, Fowler NH, Parmar S, Steiner R, Hagemeister F, Nair R, Lee HJ, Rodriguez M, Samaniego F, Iyer SP, Flowers CR, Wang L, Nastoupil LJ, Neelapu SS, Ahmed S, Strati P, Green MR, Westin J. Risk assessment with low-pass whole-genome sequencing of cell-free DNA before CD19 CAR T-cell therapy for large B-cell lymphoma. Blood. 2022 08 04; 140(5):504-515.

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Nuvvula S, Dahiya S, Patel SA. The Novel Therapeutic Landscape for Relapsed/Refractory Diffuse Large B Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022 06; 22(6):362-372.

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