Lymphoma, Large B-Cell, Diffuse

"Lymphoma, Large B-Cell, Diffuse" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Descriptor ID	D016403
MeSH Number(s)	C04.557.386.480.150.585 C15.604.515.569.480.150.585 C20.683.515.761.480.150.585
Concept/Terms	Lymphoma, Large B-Cell, Diffuse Lymphoma, Large B-Cell, Diffuse Diffuse, Large B-Cell, Lymphoma Histiocytic Lymphoma Histiocytic Lymphomas Lymphomas, Histiocytic Histiocytic Lymphoma, Diffuse Diffuse Histiocytic Lymphoma Diffuse Histiocytic Lymphomas Histiocytic Lymphomas, Diffuse Lymphoma, Diffuse Histiocytic Lymphomas, Diffuse Histiocytic Large Lymphoid Lymphoma, Diffuse Lymphoma, Large-Cell, Diffuse Lymphoma, Diffuse Large-Cell Lymphoma, Diffuse Large Cell Lymphoma, Histiocytic Lymphoma, Large Lymphoid, Diffuse Lymphoma, Histiocytic, Diffuse Lymphoma, Large Cell, Diffuse Diffuse Large-Cell Lymphoma Diffuse Large Cell Lymphoma Diffuse Large-Cell Lymphomas Large-Cell Lymphomas, Diffuse Lymphomas, Diffuse Large-Cell Large-Cell Lymphoma, Diffuse Large Cell Lymphoma, Diffuse

Below are MeSH descriptors whose meaning is more general than "Lymphoma, Large B-Cell, Diffuse".

Diseases [C]
Neoplasms [C04]
Neoplasms by Histologic Type [C04.557]
Lymphoma [C04.557.386]
Lymphoma, Non-Hodgkin [C04.557.386.480]
Lymphoma, B-Cell [C04.557.386.480.150]
Lymphoma, Large B-Cell, Diffuse [C04.557.386.480.150.585]
Hemic and Lymphatic Diseases [C15]
Lymphatic Diseases [C15.604]
Lymphoproliferative Disorders [C15.604.515]
Lymphoma [C15.604.515.569]
Lymphoma, Non-Hodgkin [C15.604.515.569.480]
Lymphoma, B-Cell [C15.604.515.569.480.150]
Lymphoma, Large B-Cell, Diffuse [C15.604.515.569.480.150.585]
Immune System Diseases [C20]
Immunoproliferative Disorders [C20.683]
Lymphoproliferative Disorders [C20.683.515]
Lymphoma [C20.683.515.761]
Lymphoma, Non-Hodgkin [C20.683.515.761.480]
Lymphoma, B-Cell [C20.683.515.761.480.150]
Lymphoma, Large B-Cell, Diffuse [C20.683.515.761.480.150.585]

Below are MeSH descriptors whose meaning is related to "Lymphoma, Large B-Cell, Diffuse".

Below are MeSH descriptors whose meaning is more specific than "Lymphoma, Large B-Cell, Diffuse".

Lymphoma, Large B-Cell, Diffuse
Plasmablastic Lymphoma

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lymphoma, Large B-Cell, Diffuse" by people in this website by year, and whether "Lymphoma, Large B-Cell, Diffuse" was a major or minor topic of these publications.

Bar chart showing 44 publications over 22 distinct years, with a maximum of 4 publications in 2014 and 2020 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
2000	0	1	1
2003	2	0	2
2004	1	0	1
2005	2	0	2
2006	2	0	2
2007	1	0	1
2008	2	0	2
2010	1	0	1
2011	3	0	3
2012	1	0	1
2013	1	0	1
2014	4	0	4
2016	3	0	3
2018	0	1	1
2020	4	0	4
2021	2	0	2
2022	2	0	2
2023	2	0	2
2024	3	1	4
2025	3	0	3

Below are the most recent publications written about "Lymphoma, Large B-Cell, Diffuse" by people in Profiles.

Gauthier J, Ahn KW, Patel J, Lian Q, Badawy S, Cairo MS, Delgado J, Grover N, Haverkos B, de Lima M, Malone A, Mussetti A, Nieto Y, Pawarode A, Pearson L, Solh M, Sureda A, Tun AM, Wudhikarn K, Yamshon S, Shadman M, Turtle CJ, Hamadani M, Herrera AF. CD19 CAR T-Cell Therapy for Primary Mediastinal Large B-Cell Lymphoma: A CIBMTR Analysis. Am J Hematol. 2025 Oct; 100(10):1792-1802.

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Anderson E, Choi Y, Buchsbaum RJ, Klein A, Ky B, Landsburg D, Durani U, Ruddy KJ, Yu AF, Leong D, Asnani A, Neilan TG, Ganatra S, Bloom M, Barac A, Yang EH, Deswal A, Cheng RK, Weiss M, Evens AM, Kahl B, Friedberg JW, Parsons SK, Upshaw JN. Hematology-oncology provider perspectives regarding lymphoma treatment and cardioprotective strategies in patients with lymphoma at high risk for heart failure. Leuk Lymphoma. 2025 Aug; 66(8):1437-1446.

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van der Heiden AD, Pensch R, Agger S, Gardner HL, Hendricks W, Zismann V, Wong S, Briones N, Turner B, Forsberg-Nilsson K, London C, Lindblad-Toh K, Arendt ML. Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival. Sci Rep. 2025 Feb 08; 15(1):4724.

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Tringale KR, Scordo M, Yahalom J, White C, Zhang Z, Vachha B, Cederquist G, Schaff L, DeAngelis L, Grommes C, Imber BS. Outcomes and relapse patterns in primary central nervous system lymphoma: Longitudinal analysis of 559 patients diagnosed from 1983 to 2020. Neuro Oncol. 2024 Nov 04; 26(11):2061-2073.

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Wang TP, Ahn KW, Shadman M, Kaur M, Ahmed N, Bacher U, Cerny J, Chen A, Epperla N, Frigault M, Grover N, Haverkos B, Hill B, Hossain N, Iqbal M, Jain T, Krem MM, Maakaron J, Modi D, Alhaj Moustafa M, Riedell P, Savani B, Sica RA, Sureda A, Wudhikarn K, Herrera AF, Sauter C, Hamadani M, Jimenez Jimenez A. Chimeric antigen receptor T-cell infusion for large B-cell lymphoma in complete remission: a center for international blood and marrow transplant research analysis. Leukemia. 2024 Jul; 38(7):1564-1569.

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McLinden GP, Avery AC, Gardner HL, Hughes K, Rodday AM, Liang K, London CA. Safety and biologic activity of a canine anti-CD20 monoclonal antibody in dogs with diffuse large B-cell lymphoma. J Vet Intern Med. 2024 May-Jun; 38(3):1666-1674.

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McCrury M, Swafford K, Shuttleworth SL, Mehdi SH, Acharya B, Saha D, Naceanceno K, Byrum SD, Storey AJ, Xu YZ, Doshier C, Patel V, Post GR, De Loose A, Rodriguez A, Shultz LD, Zhan F, Yoon D, Frett B, Kendrick S. Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma. Mol Cancer Ther. 2024 Mar 04; 23(3):316-329.

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Arun Kumar S, Mishra R, Malempati SC, Bindal P. Primary cardiac large B cell lymphoma. BMJ Case Rep. 2023 Dec 26; 16(12).

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Dittrich K, Yildiz-Altay ?, Qutab F, Kwong DA, Rao Z, Nievez-Lozano SA, Gardner HL, Richmond JM, London CA. Baseline tumor gene expression signatures correlate with chemoimmunotherapy treatment responsiveness in canine B cell lymphoma. PLoS One. 2023; 18(8):e0290428.

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Stephens DM, Li H, Constine LS, Fitzgerald TJ, Leonard JP, Kahl BS, Song JY, LeBlanc ML, Smith SM, Persky DO, Friedberg JW. Extranodal presentation in limited-stage diffuse large Bcell lymphoma as a prognostic marker in three SWOG trials S0014, S0313 and S1001. Haematologica. 2022 11 01; 107(11):2732-2736.

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