Vascular Endothelial Growth Factor C

"Vascular Endothelial Growth Factor C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.

Descriptor ID	D042582
MeSH Number(s)	D12.644.276.100.800.400 D12.776.467.100.800.400 D23.529.100.800.400
Concept/Terms	Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor C VEGF-C Vascular Endothelial Growth Factor-C

Below are MeSH descriptors whose meaning is more general than "Vascular Endothelial Growth Factor C".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Angiogenic Proteins [D12.644.276.100]
Vascular Endothelial Growth Factors [D12.644.276.100.800]
Vascular Endothelial Growth Factor C [D12.644.276.100.800.400]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Angiogenic Proteins [D12.776.467.100]
Vascular Endothelial Growth Factors [D12.776.467.100.800]
Vascular Endothelial Growth Factor C [D12.776.467.100.800.400]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Angiogenic Proteins [D23.529.100]
Vascular Endothelial Growth Factors [D23.529.100.800]
Vascular Endothelial Growth Factor C [D23.529.100.800.400]

Below are MeSH descriptors whose meaning is related to "Vascular Endothelial Growth Factor C".

Below are MeSH descriptors whose meaning is more specific than "Vascular Endothelial Growth Factor C".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Vascular Endothelial Growth Factor C" by people in this website by year, and whether "Vascular Endothelial Growth Factor C" was a major or minor topic of these publications.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2005	0	1	1
2006	0	1	1
2012	0	1	1
2013	3	0	3
2015	1	1	2
2016	1	1	2
2019	0	1	1
2021	1	0	1
2022	1	0	1

Below are the most recent publications written about "Vascular Endothelial Growth Factor C" by people in Profiles.

Peng D, Ando K, Hu?mann M, Gloger M, Skoczylas R, Mochizuki N, Betsholtz C, Fukuhara S, Schulte-Merker S, Lawson ND, Koltowska K. Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. Elife. 2022 03 22; 11.

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Jerafi-Vider A, Bassi I, Moshe N, Tevet Y, Hen G, Splittstoesser D, Shin M, Lawson ND, Yaniv K. VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells. Cell Rep. 2021 06 15; 35(11):109255.

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Stehlik J, Armstrong B, Baran DA, Bridges ND, Chandraker A, Gordon R, De Marco T, Givertz MM, Heroux A, Ikl? D, Hunt J, Kfoury AG, Madsen JC, Morrison Y, Feller E, Pinney S, Tripathi S, Heeger PS, Starling RC. Early immune biomarkers and intermediate-term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation-18. Am J Transplant. 2019 05; 19(5):1518-1528.

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Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, Babu S. Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors. J Infect. 2017 01; 74(1):10-21.

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Shin M, Male I, Beane TJ, Villefranc JA, Kok FO, Zhu LJ, Lawson ND. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2016 10 15; 143(20):3785-3795.

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Wang W, Sukamtoh E, Xiao H, Zhang G. Curcumin inhibits lymphangiogenesis in vitro and in vivo. Mol Nutr Food Res. 2015 Dec; 59(12):2345-54.

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Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW. Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form. Structure. 2015 Apr 07; 23(4):677-87.

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Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, Gerhardt H, Alitalo K, Lawson ND. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development. 2013 Apr; 140(7):1497-506.

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Daly KP, Seifert ME, Chandraker A, Zurakowski D, Nohria A, Givertz MM, Karumanchi SA, Briscoe DM. VEGF-C, VEGF-A and related angiogenesis factors as biomarkers of allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2013 Jan; 32(1):120-8.

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Dadras SS. An unexpected role for EGF in lymphangiogenesis-mediated melanoma metastasis to sentinel lymph nodes. J Invest Dermatol. 2013 Jan; 133(1):14-6.

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