Hirschsprung Disease

"Hirschsprung Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.

Descriptor ID	D006627
MeSH Number(s)	C06.198.439 C06.405.469.158.701.439 C16.131.314.439
Concept/Terms	Hirschsprung Disease Hirschsprung Disease Disease, Hirschsprung Megacolon, Congenital Hirschsprung's Disease Disease, Hirschsprung's Hirschsprungs Disease Megacolon, Aganglionic Aganglionic Megacolon Congenital Megacolon Aganglionosis, Rectosigmoid Colon Aganglionosis, Rectosigmoid Colon Rectosigmoid Colon Aganglionosis Rectosigmoid Aganglionosis Aganglionosis, Rectosigmoid Congenital Intestinal Aganglionosis Congenital Intestinal Aganglionosis Aganglionosis, Colonic Aganglionosis, Colonic Colonic Aganglionosis Total Colonic Aganglionosis Aganglionosis, Total Colonic

Below are MeSH descriptors whose meaning is more general than "Hirschsprung Disease".

Diseases [C]
Digestive System Diseases [C06]
Digestive System Abnormalities [C06.198]
Hirschsprung Disease [C06.198.439]
Gastrointestinal Diseases [C06.405]
Intestinal Diseases [C06.405.469]
Colonic Diseases [C06.405.469.158]
Megacolon [C06.405.469.158.701]
Hirschsprung Disease [C06.405.469.158.701.439]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Digestive System Abnormalities [C16.131.314]
Hirschsprung Disease [C16.131.314.439]

Below are MeSH descriptors whose meaning is related to "Hirschsprung Disease".

Below are MeSH descriptors whose meaning is more specific than "Hirschsprung Disease".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hirschsprung Disease" by people in this website by year, and whether "Hirschsprung Disease" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	1	2
2011	1	0	1
2014	1	0	1
2017	1	0	1
2024	1	0	1

Below are the most recent publications written about "Hirschsprung Disease" by people in Profiles.

Rentea RM, Bokova E, Frischer JS, Gosain A, Langer JC, Levitt MA, Nandivada P, Rialon KL, Rollins MD, Segura B, Wood RJ, Lim IIP. Evaluation and Management of Total Colonic Hirschsprung Disease: A Comprehensive Review From the American Pediatric Surgical Association (APSA) Hirschsprung Disease Interest Group. J Pediatr Surg. 2024 Nov; 59(11):161677.

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Vadva Z, Nurko S, Hehn R, Vargas SO. Rectal Suction Biopsy in Patients With Previous Anorectal Surgery for Hirschsprung Disease. J Pediatr Gastroenterol Nutr. 2017 08; 65(2):173-178.

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Aubert G, Strauss KA, Lansdorp PM, Rider NL. Defects in lymphocyte telomere homeostasis contribute to cellular immune phenotype in patients with cartilage-hair hypoplasia. J Allergy Clin Immunol. 2017 Oct; 140(4):1120-1129.e1.

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Bonaf? L, Liang J, Gorna MW, Zhang Q, Ha-Vinh R, Campos-Xavier AB, Unger S, Beckmann JS, Le B?chec A, Stevenson B, Giedion A, Liu X, Superti-Furga G, Wang W, Spahr A, Superti-Furga A. MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type. Am J Med Genet A. 2014 May; 164A(5):1175-9.

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Chumpitazi BP, Nurko S. Defecation disorders in children after surgery for Hirschsprung disease. J Pediatr Gastroenterol Nutr. 2011 Jul; 53(1):75-9.

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de la Fuente MA, Recher M, Rider NL, Strauss KA, Morton DH, Adair M, Bonilla FA, Ochs HD, Gelfand EW, Pessach IM, Walter JE, King A, Giliani S, Pai SY, Notarangelo LD. Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia. J Allergy Clin Immunol. 2011 Jul; 128(1):139-146.

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Raphael BP, Nurko S, Jiang H, Hart K, Kamin DS, Jaksic T, Duggan C. Cisapride improves enteral tolerance in pediatric short-bowel syndrome with dysmotility. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):590-4.

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Hirsch BZ, Angelides AG, Goode SP, Garb JL. Rectal biopsies obtained with jumbo biopsy forceps in the evaluation of Hirschsprung disease. J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):429-32.

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Rehman Y, Bj?rnland K, Stensrud KJ, Farstad IN, Emblem R. Low incidence of enterocolitis and colonic mucosal inflammation in Norwegian patients with Hirschsprung's disease. Pediatr Surg Int. 2009 Feb; 25(2):133-8.

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Rull?n R, Danielson P, Hirsh M, Kim D, Eckardt A, Bhattacharya K. Self-expanding silicone stent for treatment of postoperative colorectal stricture in an infant with Hirschsprung's disease: a case report. J Pediatr Surg. 2006 Sep; 41(9):1613-5.

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