"GTP Cyclohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
| Descriptor ID |
D006136
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| MeSH Number(s) |
D08.811.277.151.300
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| Concept/Terms |
GTP Cyclohydrolase- GTP Cyclohydrolase
- Cyclohydrolase, GTP
- GTP 8-Formylhydrolase
- 8-Formylhydrolase, GTP
- GTP 8 Formylhydrolase
- GTP Ring-Opening Enzyme
- GTP Ring Opening Enzyme
- Ring-Opening Enzyme, GTP
- GTP Dihydrolase
- Dihydrolase, GTP
- 7,8-Dihydroneopterintriphosphate Synthetase
- 7,8 Dihydroneopterintriphosphate Synthetase
- Synthetase, 7,8-Dihydroneopterintriphosphate
|
Below are MeSH descriptors whose meaning is more general than "GTP Cyclohydrolase".
Below are MeSH descriptors whose meaning is more specific than "GTP Cyclohydrolase".
This graph shows the total number of publications written about "GTP Cyclohydrolase" by people in this website by year, and whether "GTP Cyclohydrolase" was a major or minor topic of these publications.
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Below are the most recent publications written about "GTP Cyclohydrolase" by people in Profiles.
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Ohta E, Funayama M, Ichinose H, Toyoshima I, Urano F, Matsuo M, Tomoko N, Yukihiko K, Yoshino S, Yokoyama H, Shimazu H, Maeda K, Hasegawa K, Obata F. Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia. Arch Neurol. 2006 Nov; 63(11):1605-10.
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Furuya H, Murai H, Takasugi K, Ohyagi Y, Urano F, Kishi T, Ichinose H, Kira J. A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene. Clin Neurol Neurosurg. 2006 Dec; 108(8):784-6.
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Huang A, Zhang YY, Chen K, Hatakeyama K, Keaney JF. Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. Circ Res. 2005 Feb 04; 96(2):164-71.
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Kikuchi A, Takeda A, Fujihara K, Kimpara T, Shiga Y, Tanji H, Nagai M, Ichinose H, Urano F, Okamura N, Arai H, Itoyama Y. Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report. Mov Disord. 2004 May; 19(5):590-3.