Frameshift Mutation

"Frameshift Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.

Descriptor ID	D016368
MeSH Number(s)	G05.365.590.265
Concept/Terms	Frameshift Mutation Frameshift Mutation Frameshift Mutations Mutations, Frameshift Out-of-Frame Mutation Mutation, Out-of-Frame Mutations, Out-of-Frame Out of Frame Mutation Out-of-Frame Mutations Frame Shift Mutation Frame Shift Mutations Mutation, Frame Shift Mutations, Frame Shift Mutation, Frameshift Out-of-Frame Insertion Out-of-Frame Insertion Insertion, Out-of-Frame Insertions, Out-of-Frame Out of Frame Insertion Out-of-Frame Insertions Out-of-Frame Deletion Out-of-Frame Deletion Deletion, Out-of-Frame Deletions, Out-of-Frame Out of Frame Deletion Out-of-Frame Deletions

Below are MeSH descriptors whose meaning is more general than "Frameshift Mutation".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Frameshift Mutation [G05.365.590.265]

Below are MeSH descriptors whose meaning is more specific than "Frameshift Mutation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Frameshift Mutation" by people in this website by year, and whether "Frameshift Mutation" was a major or minor topic of these publications.

Bar chart showing 23 publications over 15 distinct years, with a maximum of 2 publications in 2008 and 2010 and 2011 and 2012 and 2013 and 2015 and 2017 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2002	0	1	1
2004	0	1	1
2005	0	1	1
2008	2	0	2
2010	1	1	2
2011	1	1	2
2012	1	1	2
2013	2	0	2
2014	0	1	1
2015	0	2	2
2017	0	2	2
2019	0	1	1
2020	2	0	2
2021	1	0	1

Below are the most recent publications written about "Frameshift Mutation" by people in Profiles.

Manakhov AD, Mintseva MY, Andreeva TV, Filimonov PA, Onokhov AA, Chernova I?, Kashtanov SN, Rogaev EI. Genome Analysis of Sable Fur Color Links a Lightened Pigmentation Phenotype to a Frameshift Variant in the Tyrosinase-Related Protein 1 Gene. Genes (Basel). 2021 01 25; 12(2).

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Pandey A, Stawiski EW, Durinck S, Gowda H, Goldstein LD, Barbhuiya MA, Schr?der MS, Sreenivasamurthy SK, Kim SW, Phalke S, Suryamohan K, Lee K, Chakraborty P, Kode V, Shi X, Chatterjee A, Datta K, Khan AA, Subbannayya T, Wang J, Chaudhuri S, Gupta S, Shrivastav BR, Jaiswal BS, Poojary SS, Bhunia S, Garcia P, Bizama C, Rosa L, Kwon W, Kim H, Han Y, Yadav TD, Ramprasad VL, Chaudhuri A, Modrusan Z, Roa JC, Tiwari PK, Jang JY, Seshagiri S. Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. Nat Commun. 2020 08 24; 11(1):4225.

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Bey AL, Gorman MP, Gallentine W, Kohlenberg TM, Frankovich J, Jiang YH, Van Haren K. Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation. Pediatrics. 2020 02; 145(2).

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Iyer S, Suresh S, Guo D, Daman K, Chen JCJ, Liu P, Zieger M, Luk K, Roscoe BP, Mueller C, King OD, Emerson CP, Wolfe SA. Precise therapeutic gene correction by a simple nuclease-induced double-stranded break. Nature. 2019 04; 568(7753):561-565.

View in: PubMed
Zou Y, Lu P, Shi J, Liu W, Yang M, Zhao S, Chen N, Chen M, Sun Y, Gao A, Chen Q, Zhang Z, Ma Q, Ning T, Ying X, Jin J, Deng X, Shen B, Zhang Y, Yuan B, Kauderer S, Liu S, Hong J, Liu R, Ning G, Wang W, Gu W, Wang J. IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk. EBioMedicine. 2017 Oct; 24:64-75.

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Xu Y, Wu Y, Guo D, Gao G, Lai K, Yang F, Wang K, Wu H, Lai L, Li J, Xu K, Li YX. Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9. Stem Cell Res. 2017 07; 22:29-32.

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Johnston AM, Niemela J, Rosenzweig SD, Fried AJ, Delmonte OM, Fleisher TA, Kuehn H. A Novel Mutation in IKBKG/NEMO Leads to Ectodermal Dysplasia with Severe Immunodeficiency (EDA-ID). J Clin Immunol. 2016 08; 36(6):541-3.

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Elf S, Abdelfattah NS, Chen E, Perales-Pat?n J, Rosen EA, Ko A, Peisker F, Florescu N, Giannini S, Wolach O, Morgan EA, Tothova Z, Losman JA, Schneider RK, Al-Shahrour F, Mullally A. Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation. Cancer Discov. 2016 Apr; 6(4):368-81.

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Proulx MK, Palace SG, Gandra S, Torres B, Weir S, Stiles T, Ellison RT, Goguen JD. Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia. J Infect Dis. 2016 Mar 15; 213(6):1041-8.

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Sahu B, Chavali VR, Alapati A, Suk J, Bartsch DU, Jablonski MM, Ayyagari R. Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model. Mol Vis. 2015; 21:273-84.

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