Header Logo

Connection

Leonard Shultz to Cell Differentiation

This is a "connection" page, showing publications Leonard Shultz has written about Cell Differentiation.
Connection Strength

1.373
  1. Ishikawa F, Saito Y, Yoshida S, Harada M, Shultz LD. The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice. Curr Top Microbiol Immunol. 2008; 324:87-94.
    View in: PubMed
    Score: 0.199
  2. Wagenblast E, Azkanaz M, Smith SA, Shakib L, McLeod JL, Krivdova G, Ara?jo J, Shultz LD, Gan OI, Dick JE, Lechman ER. Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells. Nat Commun. 2019 10 18; 10(1):4730.
    View in: PubMed
    Score: 0.113
  3. Matsuda M, Ono R, Iyoda T, Endo T, Iwasaki M, Tomizawa-Murasawa M, Saito Y, Kaneko A, Shimizu K, Yamada D, Ogonuki N, Watanabe T, Nakayama M, Koseki Y, Kezuka-Shiotani F, Hasegawa T, Yabe H, Kato S, Ogura A, Shultz LD, Ohara O, Taniguchi M, Koseki H, Fujii SI, Ishikawa F. Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice. Life Sci Alliance. 2019 04; 2(2).
    View in: PubMed
    Score: 0.109
  4. Najima Y, Tomizawa-Murasawa M, Saito Y, Watanabe T, Ono R, Ochi T, Suzuki N, Fujiwara H, Ohara O, Shultz LD, Yasukawa M, Ishikawa F. Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. Blood. 2016 Feb 11; 127(6):722-34.
    View in: PubMed
    Score: 0.087
  5. Brehm MA, Racki WJ, Leif J, Burzenski L, Hosur V, Wetmore A, Gott B, Herlihy M, Ignotz R, Dunn R, Shultz LD, Greiner DL. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood. 2012 Mar 22; 119(12):2778-88.
    View in: PubMed
    Score: 0.066
  6. Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13022-7.
    View in: PubMed
    Score: 0.059
  7. Tian X, Hexum MK, Penchev VR, Taylor RJ, Shultz LD, Kaufman DS. Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells. Stem Cells. 2009 Nov; 27(11):2675-85.
    View in: PubMed
    Score: 0.057
  8. Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, Onohara S, Miyamoto T, Minagawa H, Fujii S, Shultz LD, Harada M, Akashi K. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood. 2007 Nov 15; 110(10):3591-660.
    View in: PubMed
    Score: 0.048
  9. Kikuchi K, Lian ZX, He XS, Ansari AA, Ishibashi M, Miyakawa H, Shultz LD, Ikehara S, Gershwin ME. Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):197-202.
    View in: PubMed
    Score: 0.036
  10. Joliat MJ, Umeda S, Lyons BL, Lynes MA, Shultz LD. Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcoma. In Vivo. 2002 Jul-Aug; 16(4):223-8.
    View in: PubMed
    Score: 0.034
  11. Christianson SW, Greiner DL, Deluca D, Leif J, Phillips NE, Hayes SM, Hayashi S, Joliat MJ, Lyons BL, Shultz LD. T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7. J Autoimmun. 2002 Mar; 18(2):119-30.
    View in: PubMed
    Score: 0.033
  12. Takatsuka H, Umezu H, Hasegawa G, Usuda H, Ebe Y, Naito M, Shultz LD. Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor. J Submicrosc Cytol Pathol. 1998 Apr; 30(2):239-47.
    View in: PubMed
    Score: 0.025
  13. Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017 Jun 01; 127(6):2433-2437.
    View in: PubMed
    Score: 0.024
  14. Zhu H, Naito M, Umezu H, Moriyama H, Takatsuka H, Takahashi K, Shultz LD. Macrophage differentiation and expression of macrophage colony-stimulating factor in murine milky spots and omentum after macrophage elimination. J Leukoc Biol. 1997 Apr; 61(4):436-44.
    View in: PubMed
    Score: 0.024
  15. Naito M, Umeda S, Takahashi K, Shultz LD. Macrophage differentiation and granulomatous inflammation in osteopetrotic mice (op/op) defective in the production of CSF-1. Mol Reprod Dev. 1997 Jan; 46(1):85-91.
    View in: PubMed
    Score: 0.023
  16. Boudreau JE, Liu XR, Zhao Z, Zhang A, Shultz LD, Greiner DL, Dupont B, Hsu KC. Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I. Immunity. 2016 08 16; 45(2):280-91.
    View in: PubMed
    Score: 0.023
  17. Usuda H, Naito M, Umeda S, Takahashi K, Shultz LD. Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity. J Submicrosc Cytol Pathol. 1994 Jan; 26(1):111-9.
    View in: PubMed
    Score: 0.019
  18. Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res. 2013 Jul; 11(1):503-15.
    View in: PubMed
    Score: 0.018
  19. Takahashi K, Naito M, Shultz LD, Hayashi S, Nishikawa S. Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Leukoc Biol. 1993 Jan; 53(1):19-28.
    View in: PubMed
    Score: 0.018
  20. Takahashi K, Naito M, Shultz LD. Differentiation of epidermal Langerhans cells in macrophage colony-stimulating-factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Invest Dermatol. 1992 Nov; 99(5):46S-47S.
    View in: PubMed
    Score: 0.017
  21. Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012 Mar 22; 119(12):2768-77.
    View in: PubMed
    Score: 0.017
  22. Koo GC, Manyak CL, Dasch J, Ellingsworth L, Shultz LD. Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice. J Immunol. 1991 Aug 15; 147(4):1194-200.
    View in: PubMed
    Score: 0.016
  23. Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063.
    View in: PubMed
    Score: 0.016
  24. Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz LD, Ishikawa F. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nat Biotechnol. 2010 Mar; 28(3):275-80.
    View in: PubMed
    Score: 0.014
  25. Gori JL, Tian X, Swanson D, Gunther R, Shultz LD, McIvor RS, Kaufman DS. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Ther. 2010 Feb; 17(2):238-49.
    View in: PubMed
    Score: 0.014
  26. le Viseur C, Hotfilder M, Bomken S, Wilson K, R?ttgers S, Schrauder A, Rosemann A, Irving J, Stam RW, Shultz LD, Harbott J, J?rgens H, Schrappe M, Pieters R, Vormoor J. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell. 2008 Jul 08; 14(1):47-58.
    View in: PubMed
    Score: 0.013
  27. Gaines P, Tien CW, Olins AL, Olins DE, Shultz LD, Carney L, Berliner N. Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses. Exp Hematol. 2008 Aug; 36(8):965-76.
    View in: PubMed
    Score: 0.013
  28. Kong Y, Yoshida S, Saito Y, Doi T, Nagatoshi Y, Fukata M, Saito N, Yang SM, Iwamoto C, Okamura J, Liu KY, Huang XJ, Lu DP, Shultz LD, Harada M, Ishikawa F. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia. 2008 Jun; 22(6):1207-13.
    View in: PubMed
    Score: 0.013
  29. Yamamoto T, Kaizu C, Kawasaki T, Hasegawa G, Umezu H, Ohashi R, Sakurada J, Jiang S, Shultz L, Naito M. Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion. Cell Tissue Res. 2008 May; 332(2):245-56.
    View in: PubMed
    Score: 0.013
  30. Jaeschke A, Rinc?n M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6931-5.
    View in: PubMed
    Score: 0.010
  31. Huang Z, Coleman JM, Su Y, Mann M, Ryan J, Shultz LD, Huang H. SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner. Cytokine. 2005 Feb 07; 29(3):118-24.
    View in: PubMed
    Score: 0.010
  32. Appel MC, Banuelos SJ, Greiner DL, Shultz LD, Mordes JP, Rossini AA. Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody. Transplantation. 2004 May 15; 77(9):1341-9.
    View in: PubMed
    Score: 0.010
  33. Hayashi S, Yamada T, Tsuneto M, Yamane T, Takahashi M, Shultz LD, Yamazaki H. Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha. J Immunol. 2003 Nov 15; 171(10):5130-9.
    View in: PubMed
    Score: 0.009
  34. Shultz LD, Bailey CL, Coman DR. Hematopoietic stem cell function in motheaten mice. Exp Hematol. 1983 Aug; 11(7):667-80.
    View in: PubMed
    Score: 0.009
  35. Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol. 2003 Jul 01; 171(1):185-95.
    View in: PubMed
    Score: 0.009
  36. Capillo M, Mancuso P, Gobbi A, Monestiroli S, Pruneri G, Dell'Agnola C, Martinelli G, Shultz L, Bertolini F. Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors. Clin Cancer Res. 2003 Jan; 9(1):377-82.
    View in: PubMed
    Score: 0.009
  37. Lian ZX, Kita H, Okada T, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Ikehara S, Naiki M, Gershwin ME. Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation. Dev Immunol. 2002 Mar; 9(1):35-45.
    View in: PubMed
    Score: 0.008
  38. Kollet O, Moore JG, Aviram R, Ben-Hur H, Liu BL, Nagler A, Shultz L, Feldman M, Lapidot T. The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells. Exp Hematol. 2000 Jun; 28(6):726-36.
    View in: PubMed
    Score: 0.007
  39. Kollet O, Peled A, Byk T, Ben-Hur H, Greiner D, Shultz L, Lapidot T. beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function. Blood. 2000 May 15; 95(10):3102-5.
    View in: PubMed
    Score: 0.007
  40. Hashimoto Y, Dorshkind K, Montecino-Rodriguez E, Taguchi N, Shultz L, Gershwin ME. NZB mice exhibit a primary T cell defect in fetal thymic organ culture. J Immunol. 2000 Feb 01; 164(3):1569-75.
    View in: PubMed
    Score: 0.007
  41. Kunisada T, Yoshida H, Yamazaki H, Miyamoto A, Hemmi H, Nishimura E, Shultz LD, Nishikawa S, Hayashi S. Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors. Development. 1998 Aug; 125(15):2915-23.
    View in: PubMed
    Score: 0.006
  42. Ram?rez M, Rottman GA, Shultz LD, Civin CI. Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras. Exp Hematol. 1998 Apr; 26(4):332-44.
    View in: PubMed
    Score: 0.006
  43. Takahashi K, Miyakawa K, Wynn AA, Nakayama K, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. Am J Pathol. 1998 Feb; 152(2):445-56.
    View in: PubMed
    Score: 0.006
  44. Foy TM, McIlraith M, Masters SR, Dunn JJ, Rossini AA, Shultz LD, Hesselton RA, Wagar EJ, Lipsky PE, Noelle RJ, Greiner DL. Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice. Cell Transplant. 1998 Jan-Feb; 7(1):25-35.
    View in: PubMed
    Score: 0.006
  45. Allay JA, Dennis JE, Haynesworth SE, Majumdar MK, Clapp DW, Shultz LD, Caplan AI, Gerson SL. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum Gene Ther. 1997 Aug 10; 8(12):1417-27.
    View in: PubMed
    Score: 0.006
  46. Nakayama K, Takahashi K, Shultz LD, Miyakawa K, Tomita K. Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase. Int J Exp Pathol. 1997 Aug; 78(4):245-57.
    View in: PubMed
    Score: 0.006
  47. Hogan CJ, Shpall EJ, McNulty O, McNiece I, Dick JE, Shultz LD, Keller G. Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood. 1997 Jul 01; 90(1):85-96.
    View in: PubMed
    Score: 0.006
  48. Tapley P, Shevde NK, Schweitzer PA, Gallina M, Christianson SW, Lin IL, Stein RB, Shultz LD, Rosen J, Lamb P. Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice. Exp Hematol. 1997 Feb; 25(2):122-31.
    View in: PubMed
    Score: 0.006
  49. Naito M, Umeda S, Yamamoto T, Moriyama H, Umezu H, Hasegawa G, Usuda H, Shultz LD, Takahashi K. Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages. J Leukoc Biol. 1996 Feb; 59(2):133-8.
    View in: PubMed
    Score: 0.005
  50. Umeda S, Takahashi K, Naito M, Shultz LD, Takagi K. Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation. J Submicrosc Cytol Pathol. 1996 Jan; 28(1):13-26.
    View in: PubMed
    Score: 0.005
  51. Larochelle A, Vormoor J, Lapidot T, Sher G, Furukawa T, Li Q, Shultz LD, Olivieri NF, Stamatoyannopoulos G, Dick JE. Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. Hum Mol Genet. 1995 Feb; 4(2):163-72.
    View in: PubMed
    Score: 0.005
  52. DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y. Programmed differentiation of murine thymocytes during fetal thymus organ culture. J Immunol Methods. 1995 Jan 13; 178(1):13-29.
    View in: PubMed
    Score: 0.005
  53. Takahashi K, Umeda S, Shultz LD, Hayashi S, Nishikawa S. Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activity. J Leukoc Biol. 1994 May; 55(5):581-8.
    View in: PubMed
    Score: 0.005
  54. Hayes SM, Shultz LD, Greiner DL. Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients. Cell Immunol. 1994 Feb; 153(2):344-55.
    View in: PubMed
    Score: 0.005
  55. Kapasi ZF, Kosco-Vilbois MH, Shultz LD, Tew JG, Szakal AK. Cellular origin of follicular dendritic cells. Adv Exp Med Biol. 1994; 355:231-5.
    View in: PubMed
    Score: 0.005
  56. Katoh S, Bendig MM, Kanai Y, Shultz LD, Hitoshi Y, Takatsu K, Tominaga A. Maintenance of CD5+ B cells at an early developmental stage by interleukin-5: evidence from immunoglobulin gene usage in interleukin-5 transgenic mice. DNA Cell Biol. 1993 Jul-Aug; 12(6):481-91.
    View in: PubMed
    Score: 0.005
  57. Kapasi ZF, Burton GF, Shultz LD, Tew JG, Szakal AK. Cellular requirements for functional reconstitution of follicular dendritic cells in SCID mice. Adv Exp Med Biol. 1993; 329:383-6.
    View in: PubMed
    Score: 0.004
  58. Ohara A, Anklesaria P, Shultz L, Greenberger JS. Isolation of permanent clonal bone marrow stromal cell lines derived from "viable moth-eaten" and "severe combined immunodeficiency" mutant mice. Int J Cell Cloning. 1992 Jan; 10(1):33-46.
    View in: PubMed
    Score: 0.004
  59. Naito M, Hayashi S, Yoshida H, Nishikawa S, Shultz LD, Takahashi K. Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol. 1991 Sep; 139(3):657-67.
    View in: PubMed
    Score: 0.004
  60. Croitoru K, Stead RH, Bienenstock J, Shultz LD, Ernst PB. T cell receptor expression is not required for the localization and differentiation of intraepithelial lymphocytes. Immunol Res. 1991; 10(3-4):293-5.
    View in: PubMed
    Score: 0.004
  61. Croitoru K, Stead RH, Bienenstock J, Fulop G, Harnish DG, Shultz LD, Jeffery PK, Ernst PB. Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease. Eur J Immunol. 1990 Mar; 20(3):645-51.
    View in: PubMed
    Score: 0.004
  62. McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science. 1988 Sep 23; 241(4873):1632-9.
    View in: PubMed
    Score: 0.003
  63. Komschlies KL, Greiner DL, Shultz L, Goldschneider I. Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer. J Exp Med. 1987 Oct 01; 166(4):1162-7.
    View in: PubMed
    Score: 0.003
  64. Sidman CL, Shultz LD, Unanue ER. The mouse mutant "motheaten". I. Development of lymphocyte populations. J Immunol. 1978 Dec; 121(6):2392-8.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.