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Juleen Zierath to Muscle, Skeletal

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This is a "connection" page, showing publications Juleen Zierath has written about Muscle, Skeletal.
Juleen Zierath
Connection Strength
20.446
Muscle, Skeletal
  1. Katayama M, Nomura K, Mudry JM, Chibalin AV, Krook A, Zierath JR. Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle. Mol Metab. 2025 Feb; 92:102081.
    View in: PubMed
    Score: 0.675
  2. Karlsson HKR, Kasahara A, Ikeda M, Chibalin AV, Harada J, Ryd?n M, Krook A, Kato M, Kubota K, Zierath JR. Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study. Metabolism. 2021 05; 118:154726.
    View in: PubMed
    Score: 0.518
  3. Pillon NJ, Gabriel BM, Dollet L, Smith JAB, Sard?n Puig L, Botella J, Bishop DJ, Krook A, Zierath JR. Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity. Nat Commun. 2020 01 24; 11(1):470.
    View in: PubMed
    Score: 0.481
  4. Sardon Puig L, Pillon NJ, N?slund E, Krook A, Zierath JR. Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression. Am J Physiol Endocrinol Metab. 2020 01 01; 318(1):E1-E10.
    View in: PubMed
    Score: 0.472
  5. Borg ML, Massart J, Sch?nke M, De Castro Barbosa T, Guo L, Wade M, Alsina-Fernandez J, Miles R, Ryan A, Bauer S, Coskun T, O'Farrell E, Niemeier EM, Chibalin AV, Krook A, Karlsson HK, Brozinick JT, Zierath JR. Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice. Diabetes. 2019 07; 68(7):1403-1414.
    View in: PubMed
    Score: 0.457
  6. Gabriel BM, Zierath JR. Circadian rhythms and exercise - re-setting the clock in metabolic disease. Nat Rev Endocrinol. 2019 04; 15(4):197-206.
    View in: PubMed
    Score: 0.455
  7. Lundell LS, Massart J, Altintas A, Krook A, Zierath JR. Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle. Mol Metab. 2019 02; 20:79-88.
    View in: PubMed
    Score: 0.443
  8. Lassiter DG, Sj?gren RJO, Gabriel BM, Krook A, Zierath JR. AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle. Mol Metab. 2018 10; 16:12-23.
    View in: PubMed
    Score: 0.434
  9. Lassiter DG, Nyl?n C, Sj?gren RJO, Chibalin AV, Wallberg-Henriksson H, N?slund E, Krook A, Zierath JR. FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle. Diabetologia. 2018 02; 61(2):424-432.
    View in: PubMed
    Score: 0.411
  10. Ruby MA, Riedl I, Massart J, ?hlin M, Zierath JR. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017 10 01; 313(4):E483-E491.
    View in: PubMed
    Score: 0.404
  11. Alm PS, de Castro Barbosa T, Barr?s R, Krook A, Zierath JR. Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle. Mol Metab. 2017 07; 6(7):621-630.
    View in: PubMed
    Score: 0.400
  12. Gabriel BM, Zierath JR. The Limits of Exercise Physiology: From Performance to Health. Cell Metab. 2017 May 02; 25(5):1000-1011.
    View in: PubMed
    Score: 0.398
  13. Mudry JM, Lassiter DG, Nyl?n C, Garc?a-Calz?n S, N?slund E, Krook A, Zierath JR. Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle. Diabetes. 2017 03; 66(3):651-662.
    View in: PubMed
    Score: 0.389
  14. Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 06 14; 23(6):1034-1047.
    View in: PubMed
    Score: 0.375
  15. Riedl I, Osler ME, Bj?rnholm M, Egan B, Nader GA, Chibalin AV, Zierath JR. AMPK?3 is dispensable for skeletal muscle hypertrophy induced by functional overload. Am J Physiol Endocrinol Metab. 2016 Mar 15; 310(6):E461-72.
    View in: PubMed
    Score: 0.364
  16. Jiang LQ, de Castro Barbosa T, Massart J, Deshmukh AS, L?fgren L, Duque-Guimaraes DE, Ozilgen A, Osler ME, Chibalin AV, Zierath JR. Diacylglycerol kinase-d regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics. Am J Physiol Endocrinol Metab. 2016 Jan 01; 310(1):E51-60.
    View in: PubMed
    Score: 0.359
  17. Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014 Nov 06; 159(4):738-49.
    View in: PubMed
    Score: 0.335
  18. Al-Khalili L, de Castro Barbosa T, Ostling J, Massart J, Cuesta PG, Osler ME, Katayama M, Nystr?m AC, Oscarsson J, Zierath JR. Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C774-87.
    View in: PubMed
    Score: 0.330
  19. Zachariah Tom R, Garcia-Roves PM, Sj?gren RJ, Jiang LQ, Holmstr?m MH, Deshmukh AS, Vieira E, Chibalin AV, Bj?rnholm M, Zierath JR. Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice. Diabetes. 2014 May; 63(5):1560-71.
    View in: PubMed
    Score: 0.318
  20. Nascimento EB, Osler ME, Zierath JR. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1408-14.
    View in: PubMed
    Score: 0.311
  21. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013 Feb 05; 17(2):162-84.
    View in: PubMed
    Score: 0.297
  22. Mashili F, Chibalin AV, Krook A, Zierath JR. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes. 2013 Feb; 62(2):457-65.
    View in: PubMed
    Score: 0.290
  23. Szekeres F, Chadt A, Tom RZ, Deshmukh AS, Chibalin AV, Bj?rnholm M, Al-Hasani H, Zierath JR. The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Aug 15; 303(4):E524-33.
    View in: PubMed
    Score: 0.284
  24. Barr?s R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 07; 15(3):405-11.
    View in: PubMed
    Score: 0.279
  25. Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR. Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem. 2011 Oct 07; 286(40):34567-74.
    View in: PubMed
    Score: 0.269
  26. Sogaard P, Szekeres F, Garcia-Roves PM, Larsson D, Chibalin AV, Zierath JR. Spatial insulin signalling in isolated skeletal muscle preparations. J Cell Biochem. 2010 Apr 01; 109(5):943-9.
    View in: PubMed
    Score: 0.244
  27. Jiang LQ, Garcia-Roves PM, de Castro Barbosa T, Zierath JR. Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity. Am J Physiol Endocrinol Metab. 2010 Jan; 298(1):E8-E16.
    View in: PubMed
    Score: 0.237
  28. Deshmukh AS, Glund S, Tom RZ, Zierath JR. Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1388-94.
    View in: PubMed
    Score: 0.236
  29. Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR. Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle. Endocrinology. 2009 Feb; 150(2):600-6.
    View in: PubMed
    Score: 0.219
  30. Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR. Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes. 2008 Jun; 57(6):1508-16.
    View in: PubMed
    Score: 0.211
  31. Deshmukh AS, Treebak JT, Long YC, Viollet B, Wojtaszewski JF, Zierath JR. Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling. Mol Endocrinol. 2008 May; 22(5):1105-12.
    View in: PubMed
    Score: 0.210
  32. Bouzakri K, Zierath JR. MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem. 2007 Mar 16; 282(11):7783-9.
    View in: PubMed
    Score: 0.195
  33. Karlsson HK, Zierath JR. Insulin signaling and glucose transport in insulin resistant human skeletal muscle. Cell Biochem Biophys. 2007; 48(2-3):103-13.
    View in: PubMed
    Score: 0.195
  34. Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR. Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes. 2006 Jun; 55(6):1776-82.
    View in: PubMed
    Score: 0.187
  35. Bouzakri K, Karlsson HK, Vestergaard H, Madsbad S, Christiansen E, Zierath JR. IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients. Diabetes. 2006 Mar; 55(3):785-91.
    View in: PubMed
    Score: 0.184
  36. Ryder JW, Long YC, Nilsson E, Mahlapuu M, Zierath JR. Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle. J Physiol. 2005 Sep 01; 567(Pt 2):379-86.
    View in: PubMed
    Score: 0.175
  37. Barnes BR, Glund S, Long YC, Hj?lm G, Andersson L, Zierath JR. 5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. FASEB J. 2005 May; 19(7):773-9.
    View in: PubMed
    Score: 0.173
  38. Bouzakri K, Koistinen HA, Zierath JR. Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev. 2005 May; 1(2):167-74.
    View in: PubMed
    Score: 0.173
  39. Stocks B, Quesada JP, Mozzicato AM, Jacob C, Jensen S, MacGregor KA, Bangsbo J, Zierath JR, Hostrup M, Deshmukh AS. Temporal dynamics of the interstitial fluid proteome in human skeletal muscle following exhaustive exercise. Sci Adv. 2025 Jan 31; 11(5):eadp8608.
    View in: PubMed
    Score: 0.170
  40. Zierath JR, Hawley JA. Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol. 2004 Oct; 2(10):e348.
    View in: PubMed
    Score: 0.167
  41. Rizo-Roca D, Guimar?es DSPSF, Pendergrast LA, Di Leo N, Chibalin AV, Maqdasy S, Ryd?n M, N?slund E, Zierath JR, Krook A. Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes. Sci Transl Med. 2024 Oct 09; 16(768):eado3022.
    View in: PubMed
    Score: 0.167
  42. Krook A, Wallberg-Henriksson H, Zierath JR. Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc. 2004 Jul; 36(7):1212-7.
    View in: PubMed
    Score: 0.164
  43. Nomura K, Kinoshita S, Mizusaki N, Senga Y, Sasaki T, Kitamura T, Sakaue H, Emi A, Hosooka T, Matsuo M, Okamura H, Amo T, Wolf AM, Kamimura N, Ohta S, Itoh T, Hayashi Y, Kiyonari H, Krook A, Zierath JR, Kasuga M, Ogawa W. Adaptive gene expression of alternative splicing variants of PGC-1a regulates whole-body energy metabolism. Mol Metab. 2024 Aug; 86:101968.
    View in: PubMed
    Score: 0.163
  44. Jollet M, Tramontana F, Jiang LQ, Borg ML, Savikj M, Kuefner MS, Massart J, de Castro Barbosa T, Manner?s-Holm L, Checa A, Pillon NJ, Chibalin AV, Bj?rnholm M, Zierath JR. Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity. Metabolism. 2024 Sep; 158:155939.
    View in: PubMed
    Score: 0.163
  45. Long YC, Widegren U, Zierath JR. Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proc Nutr Soc. 2004 May; 63(2):227-32.
    View in: PubMed
    Score: 0.162
  46. Guimar?es DSPSF, Barrios NMF, de Oliveira AG, Rizo-Roca D, Jollet M, Smith JAB, Araujo TR, da Cruz MV, Marconato E, Hirabara SM, Vieira AS, Krook A, Zierath JR, Silveira LR. Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6. J Cachexia Sarcopenia Muscle. 2024 Aug; 15(4):1335-1347.
    View in: PubMed
    Score: 0.162
  47. Ashcroft SP, Stocks B, Egan B, Zierath JR. Exercise induces tissue-specific adaptations to enhance cardiometabolic health. Cell Metab. 2024 02 06; 36(2):278-300.
    View in: PubMed
    Score: 0.158
  48. Zierath JR, Kawano Y. The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle. Best Pract Res Clin Endocrinol Metab. 2003 Sep; 17(3):385-98.
    View in: PubMed
    Score: 0.154
  49. Ryder JW, Bassel-Duby R, Olson EN, Zierath JR. Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J Biol Chem. 2003 Nov 07; 278(45):44298-304.
    View in: PubMed
    Score: 0.154
  50. Steiler TL, Galuska D, Leng Y, Chibalin AV, Gilbert M, Zierath JR. Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Endocrinology. 2003 Dec; 144(12):5259-67.
    View in: PubMed
    Score: 0.154
  51. Smith JAB, Murach KA, Dyar KA, Zierath JR. Exercise metabolism and adaptation in skeletal muscle. Nat Rev Mol Cell Biol. 2023 09; 24(9):607-632.
    View in: PubMed
    Score: 0.152
  52. Kemppainen J, Tsuchida H, Stolen K, Karlsson H, Bj?rnholm M, Heinonen OJ, Nuutila P, Krook A, Knuuti J, Zierath JR. Insulin signalling and resistance in patients with chronic heart failure. J Physiol. 2003 Jul 01; 550(Pt 1):305-15.
    View in: PubMed
    Score: 0.151
  53. Yu M, Stepto NK, Chibalin AV, Fryer LG, Carling D, Krook A, Hawley JA, Zierath JR. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. J Physiol. 2003 Jan 15; 546(Pt 2):327-35.
    View in: PubMed
    Score: 0.148
  54. Pillon NJ, Smith JAB, Alm PS, Chibalin AV, Alhusen J, Arner E, Carninci P, Fritz T, Otten J, Olsson T, van Doorslaer de Ten Ryen S, Deldicque L, Caidahl K, Wallberg-Henriksson H, Krook A, Zierath JR. Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes. Sci Adv. 2022 09 09; 8(36):eabo3192.
    View in: PubMed
    Score: 0.144
  55. Barnes BR, Ryder JW, Steiler TL, Fryer LG, Carling D, Zierath JR. Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction. Diabetes. 2002 Sep; 51(9):2703-8.
    View in: PubMed
    Score: 0.144
  56. Zierath JR. Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol (1985). 2002 Aug; 93(2):773-81.
    View in: PubMed
    Score: 0.143
  57. Stocks B, Zierath JR. Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity. Endocr Rev. 2022 07 13; 43(4):654-677.
    View in: PubMed
    Score: 0.143
  58. Zierath JR, Wallberg-Henriksson H. From receptor to effector: insulin signal transduction in skeletal muscle from type II diabetic patients. Ann N Y Acad Sci. 2002 Jun; 967:120-34.
    View in: PubMed
    Score: 0.142
  59. Gonzalez-Franquesa A, Stocks B, Borg ML, Kuefner M, Dalbram E, Nielsen TS, Agrawal A, Pankratova S, Chibalin AV, Karlsson HKR, Gheibi S, Bj?rnholm M, J?rgensen NR, Clemmensen C, Hostrup M, Treebak JT, Krook A, Zierath JR, Deshmukh AS. Discovery of thymosin ?4 as a human exerkine and growth factor. Am J Physiol Cell Physiol. 2021 11 01; 321(5):C770-C778.
    View in: PubMed
    Score: 0.135
  60. Borg ML, Massart J, De Castro Barbosa T, Archilla-Ortega A, Smith JAB, Lanner JT, Alsina-Fernandez J, Yaden B, Culver AE, Karlsson HKR, Brozinick JT, Zierath JR. Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance. J Cachexia Sarcopenia Muscle. 2021 10; 12(5):1232-1248.
    View in: PubMed
    Score: 0.134
  61. Williams K, Carrasquilla GD, Ingerslev LR, Hochreuter MY, Hansson S, Pillon NJ, Donkin I, Versteyhe S, Zierath JR, Kilpel?inen TO, Barr?s R. Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health. Mol Metab. 2021 11; 53:101290.
    View in: PubMed
    Score: 0.133
  62. Sj?gren RJO, Rizo-Roca D, Chibalin AV, Chorell E, Furrer R, Katayama S, Harada J, Karlsson HKR, Handschin C, Moritz T, Krook A, N?slund E, Zierath JR. Branched-chain amino acid metabolism is regulated by ERRa in primary human myotubes and is further impaired by glucose loading in type 2 diabetes. Diabetologia. 2021 09; 64(9):2077-2091.
    View in: PubMed
    Score: 0.133
  63. Lundell LS, Parr EB, Devlin BL, Ingerslev LR, Altintas A, Sato S, Sassone-Corsi P, Barr?s R, Zierath JR, Hawley JA. Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nat Commun. 2020 09 16; 11(1):4643.
    View in: PubMed
    Score: 0.126
  64. Batista TM, Jayavelu AK, Wewer Albrechtsen NJ, Iovino S, Lebastchi J, Pan H, Dreyfuss JM, Krook A, Zierath JR, Mann M, Kahn CR. A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes. Cell Metab. 2020 11 03; 32(5):844-859.e5.
    View in: PubMed
    Score: 0.126
  65. Savikj M, Zierath JR. Train like an athlete: applying exercise interventions to manage type 2 diabetes. Diabetologia. 2020 08; 63(8):1491-1499.
    View in: PubMed
    Score: 0.124
  66. Abdelmoez AM, Sard?n Puig L, Smith JAB, Gabriel BM, Savikj M, Dollet L, Chibalin AV, Krook A, Zierath JR, Pillon NJ. Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism. Am J Physiol Cell Physiol. 2020 03 01; 318(3):C615-C626.
    View in: PubMed
    Score: 0.119
  67. Sato S, Basse AL, Sch?nke M, Chen S, Samad M, Altintas A, Laker RC, Dalbram E, Barr?s R, Baldi P, Treebak JT, Zierath JR, Sassone-Corsi P. Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. Cell Metab. 2019 07 02; 30(1):92-110.e4.
    View in: PubMed
    Score: 0.114
  68. Katayama M, Wiklander OPB, Fritz T, Caidahl K, El-Andaloussi S, Zierath JR, Krook A. Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle. Diabetes. 2019 03; 68(3):515-526.
    View in: PubMed
    Score: 0.111
  69. Sch?nke M, Massart J, Zierath JR. Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism. J Lipid Res. 2018 07; 59(7):1276-1282.
    View in: PubMed
    Score: 0.107
  70. Sch?nke M, Bj?rnholm M, Chibalin AV, Zierath JR, Deshmukh AS. Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition. Proteomics. 2018 03; 18(5-6):e1700375.
    View in: PubMed
    Score: 0.105
  71. Benziane B, Borg ML, Tom RZ, Riedl I, Massart J, Bj?rnholm M, Gilbert M, Chibalin AV, Zierath JR. DGK? deficiency protects against peripheral insulin resistance and improves energy metabolism. J Lipid Res. 2017 12; 58(12):2324-2333.
    View in: PubMed
    Score: 0.103
  72. Massart J, Sj?gren RJO, Lundell LS, Mudry JM, Franck N, O'Gorman DJ, Egan B, Zierath JR, Krook A. Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. Diabetes. 2017 07; 66(7):1807-1818.
    View in: PubMed
    Score: 0.099
  73. Manner?s-Holm L, Sch?nke M, Brozinick JT, Vetterli L, Bui HH, Sanders P, Nascimento EBM, Bj?rnholm M, Chibalin AV, Zierath JR. Diacylglycerol kinase e deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice. J Lipid Res. 2017 05; 58(5):907-915.
    View in: PubMed
    Score: 0.098
  74. Kj?bsted R, Munk-Hansen N, Birk JB, Foretz M, Viollet B, Bj?rnholm M, Zierath JR, Treebak JT, Wojtaszewski JF. Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK. Diabetes. 2017 03; 66(3):598-612.
    View in: PubMed
    Score: 0.096
  75. Mudry JM, Alm PS, Erhardt S, Goiny M, Fritz T, Caidahl K, Zierath JR, Krook A, Wallberg-Henriksson H. Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes. Diabetes Metab Res Rev. 2016 10; 32(7):754-761.
    View in: PubMed
    Score: 0.093
  76. Sch?nke M, Myers MG, Zierath JR, Bj?rnholm M. Skeletal muscle AMP-activated protein kinase ?1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity. Am J Physiol Endocrinol Metab. 2015 Oct 01; 309(7):E679-90.
    View in: PubMed
    Score: 0.089
  77. Osler ME, Fritz T, Caidahl K, Krook A, Zierath JR, Wallberg-Henriksson H. Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care. 2015 Jun; 38(6):1154-60.
    View in: PubMed
    Score: 0.086
  78. Kj?bsted R, Treebak JT, Fentz J, Lantier L, Viollet B, Birk JB, Schjerling P, Bj?rnholm M, Zierath JR, Wojtaszewski JF. Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner. Diabetes. 2015 Jun; 64(6):2042-55.
    View in: PubMed
    Score: 0.085
  79. Sj?gren RJ, Egan B, Katayama M, Zierath JR, Krook A. Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells. Physiol Genomics. 2015 Mar; 47(3):45-57.
    View in: PubMed
    Score: 0.085
  80. Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 2015 Feb; 64(2):360-9.
    View in: PubMed
    Score: 0.084
  81. Agudelo LZ, Femen?a T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DMS, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL. Skeletal muscle PGC-1a1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell. 2014 Sep 25; 159(1):33-45.
    View in: PubMed
    Score: 0.083
  82. Rasmussen M, Zierath JR, Barr?s R. Dynamic epigenetic responses to muscle contraction. Drug Discov Today. 2014 Jul; 19(7):1010-4.
    View in: PubMed
    Score: 0.080
  83. Jiang LQ, Franck N, Egan B, Sj?gren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR, Krook A. Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1359-66.
    View in: PubMed
    Score: 0.078
  84. Egan B, O'Connor PL, Zierath JR, O'Gorman DJ. Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS One. 2013; 8(9):e74098.
    View in: PubMed
    Score: 0.077
  85. Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Fr?sig C, Leick L, Fentz J, J?rgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT. AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol. 2013 Oct 15; 591(20):5207-20.
    View in: PubMed
    Score: 0.077
  86. Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath JR, Joost HG, Al-Hasani H. Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology. 2013 Oct; 154(10):3502-14.
    View in: PubMed
    Score: 0.077
  87. Russell AP, Lamon S, Boon H, Wada S, G?ller I, Brown EL, Chibalin AV, Zierath JR, Snow RJ, Stepto N, Wadley GD, Akimoto T. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J Physiol. 2013 Sep 15; 591(18):4637-53.
    View in: PubMed
    Score: 0.076
  88. Holmstr?m MH, Tom RZ, Bj?rnholm M, Garcia-Roves PM, Zierath JR. Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice. Metabolism. 2013 Sep; 62(9):1258-67.
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    Score: 0.076
  89. Barres R, Kirchner H, Rasmussen M, Yan J, Kantor FR, Krook A, N?slund E, Zierath JR. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013 Apr 25; 3(4):1020-7.
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    Score: 0.075
  90. Jiang LQ, Duque-Guimaraes DE, Machado UF, Zierath JR, Krook A. Altered response of skeletal muscle to IL-6 in type 2 diabetic patients. Diabetes. 2013 Feb; 62(2):355-61.
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    Score: 0.073
  91. Benziane B, Bj?rnholm M, Pirkmajer S, Austin RL, Kotova O, Viollet B, Zierath JR, Chibalin AV. Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. J Biol Chem. 2012 Jul 06; 287(28):23451-63.
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    Score: 0.071
  92. Yan J, Zierath JR, Barr?s R. Evidence for non-CpG methylation in mammals. Exp Cell Res. 2011 Nov 01; 317(18):2555-61.
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    Score: 0.067
  93. Mashili FL, Austin RL, Deshmukh AS, Fritz T, Caidahl K, Bergdahl K, Zierath JR, Chibalin AV, Moller DE, Kharitonenkov A, Krook A. Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev. 2011 Mar; 27(3):286-97.
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    Score: 0.065
  94. Egan B, Dowling P, O'Connor PL, Henry M, Meleady P, Zierath JR, O'Gorman DJ. 2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training. Proteomics. 2011 Apr; 11(8):1413-28.
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    Score: 0.065
  95. Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol. 2010 May 15; 588(Pt 10):1779-90.
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    Score: 0.061
  96. Cant? C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 2010 Mar 03; 11(3):213-9.
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    Score: 0.061
  97. Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD. Kinetics of GLUT4 trafficking in rat and human skeletal muscle. Diabetes. 2009 Apr; 58(4):847-54.
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    Score: 0.056
  98. Benziane B, Burton TJ, Scanlan B, Galuska D, Canny BJ, Chibalin AV, Zierath JR, Stepto NK. Divergent cell signaling after short-term intensified endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Dec; 295(6):E1427-38.
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    Score: 0.055
  99. Vieira E, Nilsson EC, Nerstedt A, Ormestad M, Long YC, Garcia-Roves PM, Zierath JR, Mahlapuu M. Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1032-7.
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    Score: 0.055
  100. Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes. 2008 Aug; 57(8):2066-73.
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    Score: 0.053
  101. Chibalin AV, Leng Y, Vieira E, Krook A, Bj?rnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nyl?n C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell. 2008 Feb 08; 132(3):375-86.
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    Score: 0.053
  102. Glund S, Deshmukh A, Long YC, Moller T, Koistinen HA, Caidahl K, Zierath JR, Krook A. Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes. 2007 Jun; 56(6):1630-7.
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    Score: 0.049
  103. Fritz T, Kr?mer DK, Karlsson HK, Galuska D, Engfeldt P, Zierath JR, Krook A. Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients. Diabetes Metab Res Rev. 2006 Nov-Dec; 22(6):492-8.
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    Score: 0.048
  104. Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 2006 Jul; 4(1):89-96.
    View in: PubMed
    Score: 0.047
  105. Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006 Jul; 116(7):1776-83.
    View in: PubMed
    Score: 0.047
  106. Karlsson HK, Ahls?n M, Zierath JR, Wallberg-Henriksson H, Koistinen HA. Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes. 2006 May; 55(5):1283-8.
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    Score: 0.046
  107. Kannisto K, Chibalin A, Glinghammar B, Zierath JR, Hamsten A, Ehrenborg E. Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise. Int J Mol Med. 2006 Jan; 17(1):45-52.
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    Score: 0.045
  108. Coffey VG, Zhong Z, Shield A, Canny BJ, Chibalin AV, Zierath JR, Hawley JA. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J. 2006 Jan; 20(1):190-2.
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    Score: 0.045
  109. Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK. Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes. 2005 Oct; 54(10):2939-45.
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    Score: 0.045
  110. Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. 2005 Jun; 54(6):1692-7.
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    Score: 0.044
  111. Barnes BR, Marklund S, Steiler TL, Walter M, Hj?lm G, Amarger V, Mahlapuu M, Leng Y, Johansson C, Galuska D, Lindgren K, Abrink M, Stapleton D, Zierath JR, Andersson L. The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem. 2004 Sep 10; 279(37):38441-7.
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    Score: 0.041
  112. Al-Khalili L, Krook A, Zierath JR, Cartee GD. Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake. Am J Physiol Endocrinol Metab. 2004 Sep; 287(3):E553-7.
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    Score: 0.041
  113. Leng Y, Karlsson HK, Zierath JR. Insulin signaling defects in type 2 diabetes. Rev Endocr Metab Disord. 2004 May; 5(2):111-7.
    View in: PubMed
    Score: 0.040
  114. Karlsson HK, Nilsson PA, Nilsson J, Chibalin AV, Zierath JR, Blomstrand E. Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E1-7.
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    Score: 0.040
  115. Storgaard H, Jensen CB, Bj?rnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA. Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. J Clin Endocrinol Metab. 2004 Mar; 89(3):1301-11.
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    Score: 0.040
  116. Al-Khalili L, Chibalin AV, Yu M, Sj?din B, Nyl?n C, Zierath JR, Krook A. MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol. 2004 Jun; 286(6):C1410-6.
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    Score: 0.040
  117. Perrini S, Henriksson J, Zierath JR, Widegren U. Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle. Diabetes. 2004 Jan; 53(1):21-4.
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    Score: 0.040
  118. Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes. 2003 May; 52(5):1066-72.
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    Score: 0.038
  119. Isaksson B, Str?mmer L, Friess H, B?chler MW, Herrington MK, Wang F, Zierath JR, Wallberg-Henriksson H, Larsson J, Permert J. Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients. Pancreas. 2003 Mar; 26(2):173-7.
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    Score: 0.037
  120. Bach D, Pich S, Soriano FX, Vega N, Baumgartner B, Oriola J, Daugaard JR, Lloberas J, Camps M, Zierath JR, Rabasa-Lhoret R, Wallberg-Henriksson H, Laville M, Palac?n M, Vidal H, Rivera F, Brand M, Zorzano A. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem. 2003 May 09; 278(19):17190-7.
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    Score: 0.037
  121. Tsuchida H, Bj?rnholm M, Fernstr?m M, Galuska D, Johansson P, Wallberg-Henriksson H, Zierath JR, Lake S, Krook A. Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects. Pflugers Arch. 2002 Oct; 445(1):25-31.
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    Score: 0.036
  122. Savikj M, Stocks B, Sato S, Caidahl K, Krook A, Deshmukh AS, Zierath JR, Wallberg-Henriksson H. Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial. Metabolism. 2022 10; 135:155268.
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    Score: 0.036
  123. Dollet L, Kuefner M, Caria E, Rizo-Roca D, Pendergrast L, Abdelmoez AM, Karlsson HKR, Bj?rnholm M, Dalbram E, Treebak JT, Harada J, N?slund E, Ryd?n M, Zierath JR, Pillon NJ, Krook A. Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes. Diabetes. 2022 04 01; 71(4):624-636.
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    Score: 0.035
  124. Massart J, Sj?gren RJO, Egan B, Garde C, Lindgren M, Gu W, Ferreira DMS, Katayama M, Ruas JL, Barr?s R, O'Gorman DJ, Zierath JR, Krook A. Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. Nat Commun. 2021 10 12; 12(1):5948.
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    Score: 0.034
  125. Small L, Altintas A, Laker RC, Ehrlich A, Pattamaprapanont P, Villarroel J, Pillon NJ, Zierath JR, Barr?s R. Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway. J Physiol. 2020 12; 598(24):5739-5752.
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    Score: 0.032
  126. Dalbram E, Basse AL, Zierath JR, Treebak JT. Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action. J Appl Physiol (1985). 2019 04 01; 126(4):993-1005.
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    Score: 0.028
  127. Nyl?n C, Lundell LS, Massart J, Zierath JR, N?slund E. Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E178-E185.
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    Score: 0.028
  128. Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schi?th HB, Benedict C. Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men. J Clin Endocrinol Metab. 2015 Sep; 100(9):E1255-61.
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    Score: 0.022
  129. Moltke I, Grarup N, J?rgensen ME, Bjerregaard P, Treebak JT, Fumagalli M, Korneliussen TS, Andersen MA, Nielsen TS, Krarup NT, Gjesing AP, Zierath JR, Linneberg A, Wu X, Sun G, Jin X, Al-Aama J, Wang J, Borch-Johnsen K, Pedersen O, Nielsen R, Albrechtsen A, Hansen T. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature. 2014 Aug 14; 512(7513):190-3.
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    Score: 0.020
  130. Kulkarni SS, Salehzadeh F, Fritz T, Zierath JR, Krook A, Osler ME. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism. 2012 Feb; 61(2):175-85.
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    Score: 0.017
  131. Benziane B, Bj?rnholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1554-66.
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    Score: 0.015
  132. Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palac?n M, Mingrone G, Zierath JR, Vidal H, Zorzano A. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes. 2005 Sep; 54(9):2685-93.
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    Score: 0.011
  133. Kr?mer DK, Al-Khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, Wallberg-Henriksson H, Ehrenborg E, Zierath JR, Krook A. Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 2005 Apr; 54(4):1157-63.
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    Score: 0.011
  134. Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J. 2002 Aug; 16(10):1163-76.
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    Score: 0.009
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The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.