Anastasia Khvorova to RNA Interference
This is a "connection" page, showing publications Anastasia Khvorova has written about RNA Interference.
Connection Strength
6.835
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Belgrad J, Summers A, Landles C, Greene JR, Hildebrand S, Knox E, Sapp E, Yamada N, Furgal R, Miller R, Osborne GF, Chase K, Luu E, Freedman J, Bramato B, McHugh N, Nnah I, Benoit V, O'Reilly D, Greer P, Bates GP, Vogt TF, Lee R, Howland D, DiFiglia M, Aronin N, Khvorova A. Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice. Sci Transl Med. 2026 Aug 12; 18(862):eaea3104.
Score: 0.751
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Weiss A, Gilbert JW, Rivera Flores IV, Belgrad J, Ferguson C, Dogan EO, Wightman N, Mocarski K, Echeverria D, Harkins AL, Summers A, Bramato B, McHugh N, Furgal R, Yamada N, Cooper D, Monopoli K, Godinho BMDC, Hassler MR, Yamada K, Greer P, Henninger N, Brown RH, Khvorova A. RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. Mol Ther. 2025 Aug 06; 33(8):3917-3938.
Score: 0.688
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Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Res. 2024 05 22; 52(9):5273-5284.
Score: 0.644
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Tang Q, Khvorova A. RNAi-based drug design: considerations and future directions. Nat Rev Drug Discov. 2024 05; 23(5):341-364.
Score: 0.638
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Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A. Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs. Mol Cancer Ther. 2018 06; 17(6):1251-1258.
Score: 0.421
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Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, Moore MJ, Aronin N, Khvorova A. Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Res. 2018 03 16; 46(5):2185-2196.
Score: 0.419
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Osborn MF, Alterman JF, Nikan M, Cao H, Didiot MC, Hassler MR, Coles AH, Khvorova A. Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs. Nucleic Acids Res. 2015 Oct 15; 43(18):8664-72.
Score: 0.353
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Birmingham A, Anderson E, Sullivan K, Reynolds A, Boese Q, Leake D, Karpilow J, Khvorova A. A protocol for designing siRNAs with high functionality and specificity. Nat Protoc. 2007; 2(9):2068-78.
Score: 0.193
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Reynolds A, Anderson EM, Vermeulen A, Fedorov Y, Robinson K, Leake D, Karpilow J, Marshall WS, Khvorova A. Induction of the interferon response by siRNA is cell type- and duplex length-dependent. RNA. 2006 Jun; 12(6):988-93.
Score: 0.183
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Trampel KA, Gross KY, O'Reilly D, Melisova A, Salman B, Green S, George SA, Khvorova A, Efimov IR, Efimova T. RNAi-mediated p38? silencing mitigates anthracycline cardiotoxicity in female mice. Am J Physiol Heart Circ Physiol. 2026 05 01; 330(5):H1522-H1539.
Score: 0.183
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O'Reilly D, Furgal RC, Ross VM, Luu E, Gross KY, Hariharan V, Summers A, Cooper D, Allen S, Dahlke C, Rachid MO, Chan IL, Fakih HH, Alterman JF, Echeverria D, Watts JK, Khvorova A. Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo. Nucleic Acids Res. 2026 Jan 05; 54(1).
Score: 0.180
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Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy. Nucleic Acids Res. 2025 Jun 20; 53(12).
Score: 0.173
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Boese Q, Leake D, Reynolds A, Read S, Scaringe SA, Marshall WS, Khvorova A. Mechanistic insights aid computational short interfering RNA design. Methods Enzymol. 2005; 392:73-96.
Score: 0.168
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Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 06 24; 52(11):6099-6113.
Score: 0.162
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Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Rational siRNA design for RNA interference. Nat Biotechnol. 2004 Mar; 22(3):326-30.
Score: 0.158
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Khvorova A. siRNAs-A New Class of Medicines. JAMA. 2023 06 27; 329(24):2185-2186.
Score: 0.151
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Tang Q, Sousa J, Echeverria D, Fan X, Hsueh YC, Afshari K, MeHugh N, Cooper DA, Vangjeli L, Monopoli K, Okamura K, Biscans A, Clauss A, Harris JE, Khvorova A. RNAi-based modulation of IFN-? signaling in skin. Mol Ther. 2022 08 03; 30(8):2709-2721.
Score: 0.139
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Biscans A, Caiazzi J, Davis S, McHugh N, Sousa J, Khvorova A. The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy. Nucleic Acids Res. 2020 08 20; 48(14):7665-7680.
Score: 0.124
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Biscans A, Coles A, Echeverria D, Khvorova A. The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo. J Control Release. 2019 05 28; 302:116-125.
Score: 0.113
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Osborn MF, Coles AH, Biscans A, Haraszti RA, Roux L, Davis S, Ly S, Echeverria D, Hassler MR, Godinho BMDC, Nikan M, Khvorova A. Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways. Nucleic Acids Res. 2019 02 20; 47(3):1070-1081.
Score: 0.112
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Biscans A, Coles A, Haraszti R, Echeverria D, Hassler M, Osborn M, Khvorova A. Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo. Nucleic Acids Res. 2019 02 20; 47(3):1082-1096.
Score: 0.112
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Shmushkovich T, Monopoli KR, Homsy D, Leyfer D, Betancur-Boissel M, Khvorova A, Wolfson AD. Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs. Nucleic Acids Res. 2018 11 16; 46(20):10905-10916.
Score: 0.110
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Biscans A, Haraszti RA, Echeverria D, Miller R, Didiot MC, Nikan M, Roux L, Aronin N, Khvorova A. Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles. Mol Ther. 2018 06 06; 26(6):1520-1528.
Score: 0.105
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Nikan M, Osborn MF, Coles AH, Biscans A, Godinho BMDC, Haraszti RA, Sapp E, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain. Bioconjug Chem. 2017 06 21; 28(6):1758-1766.
Score: 0.099
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Byrne M, Tzekov R, Wang Y, Rodgers A, Cardia J, Ford G, Holton K, Pandarinathan L, Lapierre J, Stanney W, Bulock K, Shaw S, Libertine L, Fettes K, Khvorova A, Kaushal S, Pavco P. Novel hydrophobically modified asymmetric RNAi compounds (sd-rxRNA) demonstrate robust efficacy in the eye. J Ocul Pharmacol Ther. 2013 Dec; 29(10):855-64.
Score: 0.077
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Lapierre J, Salomon W, Cardia J, Bulock K, Lam JT, Stanney WJ, Ford G, Smith-Anzures B, Woolf T, Kamens J, Khvorova A, Samarsky D. Potent and systematic RNAi mediated silencing with single oligonucleotide compounds. RNA. 2011 Jun; 17(6):1032-7.
Score: 0.065
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Anderson EM, Birmingham A, Baskerville S, Reynolds A, Maksimova E, Leake D, Fedorov Y, Karpilow J, Khvorova A. Experimental validation of the importance of seed complement frequency to siRNA specificity. RNA. 2008 May; 14(5):853-61.
Score: 0.053
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Anderson E, Boese Q, Khvorova A, Karpilow J. Identifying siRNA-induced off-targets by microarray analysis. Methods Mol Biol. 2008; 442:45-63.
Score: 0.052
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Li L, Lin X, Khvorova A, Fesik SW, Shen Y. Defining the optimal parameters for hairpin-based knockdown constructs. RNA. 2007 Oct; 13(10):1765-74.
Score: 0.050
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Tocheny CE, Buchwald JE, Dahlke CD, Fakih HH, Morgan JS, Summers A, Silva CA, Jackson SO, Lee JS, Card MA, Echeverria D, Peterson C, Mercurio AM, Khvorova A, Shaw LM. Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth. Mol Ther. 2026 May 06; 34(5):2963-2982.
Score: 0.045
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Hsieh AC, Bo R, Manola J, Vazquez F, Bare O, Khvorova A, Scaringe S, Sellers WR. A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res. 2004; 32(3):893-901.
Score: 0.039
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Wilson JA, Jayasena S, Khvorova A, Sabatinos S, Rodrigue-Gervais IG, Arya S, Sarangi F, Harris-Brandts M, Beaulieu S, Richardson CD. RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2783-8.
Score: 0.037
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Thijssen MF, Brüggenwirth IMA, Gillooly A, Khvorova A, Kowalik TF, Martins PN. Gene Silencing With siRNA (RNA Interference): A New Therapeutic Option During Ex Vivo Machine Liver Perfusion Preservation Liver Transpl. 2019 01; 25(1):140-151.
Score: 0.028
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Huang F, Khvorova A, Marshall W, Sorkin A. Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem. 2004 Apr 16; 279(16):16657-61.
Score: 0.010