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Edward Kelly to Humans

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This is a "connection" page, showing publications Edward Kelly has written about Humans.
Edward Kelly
Connection Strength
0.550
Humans
  1. O'Mahony ET, Arian CM, Aryeh KS, Wang K, Thummel KE, Kelly EJ. Human intestinal enteroids: Nonclinical applications for predicting oral drug disposition, toxicity, and efficacy. Pharmacol Ther. 2025 Sep; 273:108879.
    View in: PubMed
    Score: 0.036
  2. Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ. Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. Sci Rep. 2021 11 01; 11(1):21356.
    View in: PubMed
    Score: 0.028
  3. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 02 25; 11(1):4722.
    View in: PubMed
    Score: 0.027
  4. Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ. Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology. 2020 11; 444:152582.
    View in: PubMed
    Score: 0.026
  5. Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. JCI Insight. 2018 12 20; 3(24).
    View in: PubMed
    Score: 0.023
  6. Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological Systems to Assess Nonclinical Toxicity. Curr Protoc Toxicol. 2017 Aug 04; 73:14.18.1-14.18.28.
    View in: PubMed
    Score: 0.021
  7. Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ. Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. Br J Ophthalmol. 2018 02; 102(2):187-194.
    View in: PubMed
    Score: 0.021
  8. Bedeir K, Seethala R, Kelly E. Extracorporeal life support in trauma: Worth the risks? A systematic review of published series. J Trauma Acute Care Surg. 2017 02; 82(2):400-406.
    View in: PubMed
    Score: 0.020
  9. Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney Int. 2016 09; 90(3):627-37.
    View in: PubMed
    Score: 0.020
  10. Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy V, Rettie AE. Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Mol Interv. 2011 Apr; 11(2):124-32.
    View in: PubMed
    Score: 0.014
  11. Arian CM, O'Mahony ET, Manwill PK, Graf TN, Oberlies NH, Cech NB, Clarke JD, Smith JG, Paine MF, Kelly EJ, Thummel KE. A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption. J Pharmacol Exp Ther. 2025 Jun; 392(6):103597.
    View in: PubMed
    Score: 0.009
  12. Ziedins EE, Kelly EJ, Le TD, Carney BC, Mathew SK, Pinto DN, Pierson BE, D'Orio CS, Hockstein MA, Moffatt LT, Shupp JW. Markers of Endothelial Injury in Extracorporeal Membrane Oxygenation: A New Risk Assessment Method. J Surg Res. 2024 Dec; 304:391-399.
    View in: PubMed
    Score: 0.009
  13. Arian C, O'Mahony E, MacDonald JW, Bammler TK, Donowitz M, Kelly EJ, Thummel KE. Human enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition. Drug Metab Dispos. 2025 Jan; 53(1):100002.
    View in: PubMed
    Score: 0.009
  14. Hart A, Cesar F, Zelnick LR, O'Connor N, Bailey Z, Lo J, Van Ness K, Stanaway IB, Bammler TK, MacDonald JW, Thau MR, Himmelfarb J, Goss CH, Aitken M, Kelly EJ, Bhatraju PK. Identification of prognostic biomarkers for antibiotic associated nephrotoxicity in cystic fibrosis. J Cyst Fibros. 2024 Mar; 23(2):293-299.
    View in: PubMed
    Score: 0.008
  15. Chang SY, Huang W, Chapron A, Qui?ones AJL, Wang J, Isoherranen N, Shen DD, Kelly EJ, Himmelfarb J, Yeung CK. Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease. Pharm Res. 2023 Nov; 40(11):2597-2606.
    View in: PubMed
    Score: 0.008
  16. Sun A, Hagenbuch B, Kelly EJ, Wang J. Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. Mol Pharmacol. 2023 Dec; 104(6):255-265.
    View in: PubMed
    Score: 0.008
  17. Kamine TH, Siu M, Kramer KZ, Alouidor R, Kelly E, Deutsch A, Mader TJ, Visintainer P, Grochowski K, Jabbour N. Feasibility and Acceptance of a Teletrauma Surgery Consult Service to Rural and Community Hospitals: A Pilot Study. J Am Coll Surg. 2023 01 01; 236(1):145-153.
    View in: PubMed
    Score: 0.008
  18. Siu M, Levin D, Christiansen R, Kelly E, Alouidor R, Kamine TH. Prophylactic Splenectomy and Hyposplenism in Spaceflight. Aerosp Med Hum Perform. 2022 Dec 01; 93(12):877-881.
    View in: PubMed
    Score: 0.008
  19. Levin DR, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Kamine T. Time Cost of Provider Skill: A Pilot Study of Medical Officer Occupied Time By Knowledge, Skill, and Ability Level. Aerosp Med Hum Perform. 2022 Nov 01; 93(11):816-821.
    View in: PubMed
    Score: 0.008
  20. Kamine TH, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Levin D. Spatial Volume Necessary to Perform Open Appendectomy in a Spacecraft. Aerosp Med Hum Perform. 2022 Oct 01; 93(10):760-763.
    View in: PubMed
    Score: 0.008
  21. Kamine TH, Dhanani H, Wilcox S, Kelly E, Alouidor R, Kramer K, Carey Y, Ryb G, Putnam AT, Winston E, Cohen J. American Helicopter Emergency Medical Service Pilots Report to Work Despite High Rates of Sleepiness. Air Med J. 2022 Sep-Oct; 41(5):432-434.
    View in: PubMed
    Score: 0.007
  22. Lidberg KA, Muthusamy S, Adil M, Mahadeo A, Yang J, Patel RS, Wang L, Bammler TK, Reichel J, Yeung CK, Himmelfarb J, Kelly EJ, Akilesh S. Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury. J Am Soc Nephrol. 2022 05; 33(5):949-965.
    View in: PubMed
    Score: 0.007
  23. Arian CM, Imaoka T, Yang J, Kelly EJ, Thummel KE. Gutsy science: In vitro systems of the human intestine to model oral drug disposition. Pharmacol Ther. 2022 02; 230:107962.
    View in: PubMed
    Score: 0.007
  24. Kowalski JP, Pelletier RD, McDonald MG, Kelly EJ, Rettie AE. Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: ?-oxidation as a potential augmenting pathway for inhibition. Xenobiotica. 2021 Aug; 51(8):901-915.
    View in: PubMed
    Score: 0.007
  25. Nieskens TTG, Persson M, Kelly EJ, Sj?gren AK. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity. Drug Metab Dispos. 2020 12; 48(12):1303-1311.
    View in: PubMed
    Score: 0.007
  26. Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B. Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human. Mol Pharm. 2020 11 02; 17(11):4114-4124.
    View in: PubMed
    Score: 0.007
  27. Zhang A, Li CY, Kelly EJ, Sheppard L, Cui JY. Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism. PLoS One. 2020; 15(2):e0224644.
    View in: PubMed
    Score: 0.006
  28. Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro. 2020 Mar; 63:104752.
    View in: PubMed
    Score: 0.006
  29. Patel RC, Stalter RM, Thomas KK, Tamraz B, Blue SW, Erikson DW, Kim CJ, Kelly EJ, Nanda K, Kourtis AP, Lingappa JR, Mugo N, Baeten JM, Scarsi KK. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS. 2019 11 01; 33(13):1995-2004.
    View in: PubMed
    Score: 0.006
  30. Lyu HG, Castillo-Angeles M, Bruno M, Cooper Z, Nehra D, Nitzschke SL, Askari R, Kelly E, Shimizu N, Riviello R, Salim A, Havens JM. Outcomes of a low-osmolar water-soluble contrast pathway in small bowel obstruction. J Trauma Acute Care Surg. 2019 09; 87(3):630-635.
    View in: PubMed
    Score: 0.006
  31. Maass C, Sorensen NB, Himmelfarb J, Kelly EJ, Stokes CL, Cirit M. Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System. CPT Pharmacometrics Syst Pharmacol. 2019 05; 8(5):316-325.
    View in: PubMed
    Score: 0.006
  32. Sachar M, Kelly EJ, Unadkat JD. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. AAPS J. 2019 03 27; 21(3):45.
    View in: PubMed
    Score: 0.006
  33. Taghavi S, Castillo-Angeles M, Uribe-Leitz T, Hirji S, Armand P, Nehra D, Cooper Z, Kelly E, Havens J, Haider A, Salim A, Askari R. Emergency general surgery procedures in hematopoietic stem cell transplant recipients. Am J Surg. 2019 11; 218(5):972-977.
    View in: PubMed
    Score: 0.006
  34. Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y. Reconstructing the Human Renal Vascular-Tubular Unit In Vitro. Adv Healthc Mater. 2018 12; 7(23):e1801120.
    View in: PubMed
    Score: 0.006
  35. Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS. A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. J Am Soc Nephrol. 2018 12; 29(12):2820-2833.
    View in: PubMed
    Score: 0.006
  36. Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I. Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Sci Rep. 2018 10 05; 8(1):14882.
    View in: PubMed
    Score: 0.006
  37. Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metab Dispos. 2018 11; 46(11):1692-1702.
    View in: PubMed
    Score: 0.006
  38. Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system ALTEX. 2018; 35(4):504-515.
    View in: PubMed
    Score: 0.006
  39. Yorkgitis BK, Olufajo OA, Gurien LA, Kelly E, Salim A, Askari R. Risk factors for prolonged need for percutaneous endoscopic gastrostomy (PEG) tubes in adult trauma patients: Experience of a level 1 trauma. Surgery. 2018 12; 164(6):1259-1262.
    View in: PubMed
    Score: 0.006
  40. Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight. 2017 11 16; 2(22).
    View in: PubMed
    Score: 0.005
  41. Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD. Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics. Drug Metab Dispos. 2018 02; 46(2):189-196.
    View in: PubMed
    Score: 0.005
  42. Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicol In Vitro. 2017 Apr; 40:170-183.
    View in: PubMed
    Score: 0.005
  43. Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD. Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics. Drug Metab Dispos. 2016 12; 44(12):1920-1924.
    View in: PubMed
    Score: 0.005
  44. Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys W, Hop CE, Kumer SC, Unadkat JD. Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug Metab Dispos. 2016 11; 44(11):1752-1758.
    View in: PubMed
    Score: 0.005
  45. Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metab Dispos. 2016 10; 44(10):1598-602.
    View in: PubMed
    Score: 0.005
  46. Olufajo OA, Yorkgitis BK, Cooper Z, Rios-Diaz A, Metcalfe D, Havens JM, Kelly E, Haider AH, Gates JD, Salim A. How long should we fear? Long-term risk of venous thromboembolism in patients with traumatic brain injury. J Trauma Acute Care Surg. 2016 07; 81(1):71-8.
    View in: PubMed
    Score: 0.005
  47. Farooq M, Kelly EJ, Unadkat JD. CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug Metab Dispos. 2016 May; 44(5):750-7.
    View in: PubMed
    Score: 0.005
  48. Olufajo OA, Tulebaev S, Javedan H, Gates J, Wang J, Duarte M, Kelly E, Lilley E, Salim A, Cooper Z. Integrating Geriatric Consults into Routine Care of Older Trauma Patients: One-Year Experience of a Level I Trauma Center. J Am Coll Surg. 2016 06; 222(6):1029-35.
    View in: PubMed
    Score: 0.005
  49. Olufajo OA, Metcalfe D, Rios-Diaz A, Lilley E, Havens JM, Kelly E, Weissman JS, Haider AH, Salim A, Cooper Z. Does Hospital Experience Rather than Volume Improve Outcomes in Geriatric Trauma Patients? J Am Coll Surg. 2016 07; 223(1):32-40.e1.
    View in: PubMed
    Score: 0.005
  50. Havens JM, Do WS, Kaafarani H, Mesar T, Reznor G, Cooper Z, Askari R, Kelly E, Columbus AB, Gates JD, Haider AH, Salim A. Explaining the excess morbidity of emergency general surgery: packed red blood cell and fresh frozen plasma transfusion practices are associated with major complications in nonmassively transfused patients. Am J Surg. 2016 Apr; 211(4):656-663.e4.
    View in: PubMed
    Score: 0.005
  51. Ryu RJ, Eyal S, Easterling TR, Caritis SN, Venkataraman R, Hankins G, Rytting E, Thummel K, Kelly EJ, Risler L, Phillips B, Honaker MT, Shen DD, Hebert MF. Pharmacokinetics of metoprolol during pregnancy and lactation. J Clin Pharmacol. 2016 May; 56(5):581-9.
    View in: PubMed
    Score: 0.005
  52. Cooper Z, Goel N, Gutnik L, Reznor G, Lilley E, Williams KJ, Salim A, Kelly E, Zinner MJ. How Many Midnights?: Admission Status for Elders With Small Bowel Obstruction. Ann Surg. 2015 Dec; 262(6):904-6.
    View in: PubMed
    Score: 0.005
  53. Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr; 27(4):1015-28.
    View in: PubMed
    Score: 0.005
  54. Havens JM, Peetz AB, Do WS, Cooper Z, Kelly E, Askari R, Reznor G, Salim A. The excess morbidity and mortality of emergency general surgery. J Trauma Acute Care Surg. 2015 Feb; 78(2):306-11.
    View in: PubMed
    Score: 0.004
  55. Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H. Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. Biochem J. 2015 Jan 01; 465(1):103-14.
    View in: PubMed
    Score: 0.004
  56. Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15; 92(4):690-700.
    View in: PubMed
    Score: 0.004
  57. Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J. Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metab Dispos. 2013 Dec; 41(12):2225-32.
    View in: PubMed
    Score: 0.004
  58. van der Wilden GM, Velmahos GC, Joseph DK, Jacobs L, Debusk MG, Adams CA, Gross R, Burkott B, Agarwal S, Maung AA, Johnson DC, Gates J, Kelly E, Michaud Y, Charash WE, Winchell RJ, Desjardins SE, Rosenblatt MS, Gupta S, Gaeta M, Chang Y, de Moya MA. Successful nonoperative management of the most severe blunt renal injuries: a multicenter study of the research consortium of New England Centers for Trauma. JAMA Surg. 2013 Oct; 148(10):924-31.
    View in: PubMed
    Score: 0.004
  59. Ho MT, Kelly EJ, Bodor M, Bui T, Kowdley KV, Ho RJ. Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects. Ann Hepatol. 2011 Jul-Sep; 10(3):327-32.
    View in: PubMed
    Score: 0.003
  60. Crouthamel MH, Kelly EJ, Ho RJ. Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers. Transgenic Res. 2012 Feb; 21(1):113-30.
    View in: PubMed
    Score: 0.003
  61. Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GD, Clark SM, Risler L, Wang J, Kelly EJ, Shen DD, Hebert MF. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos. 2010 May; 38(5):833-40.
    View in: PubMed
    Score: 0.003
  62. Nakano M, Kelly EJ, Rettie AE. Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab Dispos. 2009 Nov; 37(11):2119-22.
    View in: PubMed
    Score: 0.003
  63. Havens JM, Kelly E, Patel V. A 78-year-old man with an elevated hemidiaphragm following trauma. Chest. 2008 Dec; 134(6):1336-1339.
    View in: PubMed
    Score: 0.003
  64. Bodor M, Kelly EJ, Ho RJ. Characterization of the human MDR1 gene. AAPS J. 2005 Feb 16; 7(1):E1-5.
    View in: PubMed
    Score: 0.002
  65. McConnachie LA, Bodor M, Phillips B, Kelly EJ, Shen DD, Ho RJ. An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number. Genet Test. 2004; 8(3):313-8.
    View in: PubMed
    Score: 0.002
  66. Hashmi S, Kelly E, Rogers SO, Gates J. Urinary tract infection in surgical patients. Am J Surg. 2003 Jul; 186(1):53-6.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.