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Edward Kelly MD

TitleAssociate Professor
InstitutionUMass Chan – Baystate Regional Campus
DepartmentSurgery at UMass Chan - Baystate
AddressBaystate Health Regional Campus
759 Chestnut Street
Springfield MA 01199
Phone413-794-4022
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    Collapse Biography 
    Collapse education and training
    University of Scranton, Scranton, PA, United StatesBSBiology
    University of Pittsburgh, Pittsburgh, PA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim P, Murphy P, Kelly E, Haddad DN, Martin RS, Spain DA, Smith JW, Savage SA, Staudenmayer KL. Making the case for value of acute care surgery: American Association for the Surgery of Trauma panel on overcoming local challenges. J Trauma Acute Care Surg. 2025 Aug 13. PMID: 40802502.
      Citations:    
    2. Hansen BC, Arian CM, Zeng Y, Takezawa MG, Theberge AB, Faustman EM, Thummel KE, Kelly EJ. Leveraging RNA-seq deconvolution to improve complex in vitro model characterization. J Biol Chem. 2025 Jul 21; 301(9):110510. PMID: 40701251.
      Citations:    
    3. Tsang YP, Aryeh KS, Wang K, Himmelfarb J, Yeung CK, Kelly EJ. Enhancing therapeutic strategies and drug development for patients with kidney disease. Expert Opin Drug Saf. 2025 Jul 04; 1-26. PMID: 40568828.
      Citations:    
    4. Arian CM, O'Mahony ET, Manwill PK, Graf TN, Oberlies NH, Cech NB, Clarke JD, Smith JG, Paine MF, Kelly EJ, Thummel KE. Corrigendum to 'A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption' [The Journal of Pharmacology and Experimental Therapeutics 392 (2025) 103597]. J Pharmacol Exp Ther. 2025 Jul; 392(7):103628. PMID: 40505413.
      Citations:    
    5. O'Mahony ET, Arian CM, Aryeh KS, Wang K, Thummel KE, Kelly EJ. Human intestinal enteroids: Nonclinical applications for predicting oral drug disposition, toxicity, and efficacy. Pharmacol Ther. 2025 Sep; 273:108879. PMID: 40398537.
      Citations:    
    6. Arian CM, O'Mahony ET, Manwill PK, Graf TN, Oberlies NH, Cech NB, Clarke JD, Smith JG, Paine MF, Kelly EJ, Thummel KE. A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption. J Pharmacol Exp Ther. 2025 Jun; 392(6):103597. PMID: 40403579.
      Citations:    
    7. Ziedins EE, Kelly EJ, Le TD, Carney BC, Mathew SK, Pinto DN, Pierson BE, D'Orio CS, Hockstein MA, Moffatt LT, Shupp JW. Markers of Endothelial Injury in Extracorporeal Membrane Oxygenation: A New Risk Assessment Method. J Surg Res. 2024 Dec; 304:391-399. PMID: 39616823.
      Citations:    
    8. Arian C, O'Mahony E, MacDonald JW, Bammler TK, Donowitz M, Kelly EJ, Thummel KE. Human enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition. Drug Metab Dispos. 2025 Jan; 53(1):100002. PMID: 39884814.
      Citations:    
    9. Arian C, O'Mahony E, MacDonald JW, Bammler TK, Donowitz M, Kelly EJ, Thummel KE. Human Enteroid Monolayers: A Novel, Functionally-Stable Model for Investigating Oral Drug Disposition. Drug Metab Dispos. 2024 Aug 09. PMID: 38744527.
      Citations:    
    10. Lidberg KA, Jones-Isaac K, Yang J, Bain J, Wang L, MacDonald JW, Bammler TK, Calamia J, Thummel KE, Yeung CK, Countryman S, Koenig P, Himmelfarb J, Kelly EJ. Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system. NPJ Microgravity. 2024 Jul 09; 10(1):75. PMID: 38982119.
      Citations:    
    11. Kelly EJ, Ziedins EE, Carney BC, Moffatt LT, Shupp JW. Endothelial dysfunction is dampened by early administration of fresh frozen plasma in a rodent burn shock model. J Trauma Acute Care Surg. 2024 Oct 01; 97(4):520-528. PMID: 38764137.
      Citations:    
    12. Jones-Isaac KA, Lidberg KA, Yeung CK, Yang J, Bain J, Ruiz M, Koenig G, Koenig P, Countryman S, Himmelfarb J, Kelly EJ. Development of a kidney microphysiological system hardware platform for microgravity studies. NPJ Microgravity. 2024 May 11; 10(1):54. PMID: 38734683.
      Citations:    
    13. Tsang YP, Hao T, Mao Q, Kelly EJ, Unadkat JD. Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells. Pharmaceutics. 2024 Feb 16; 16(2). PMID: 38399338.
      Citations:    
    14. Hart A, Cesar F, Zelnick LR, O'Connor N, Bailey Z, Lo J, Van Ness K, Stanaway IB, Bammler TK, MacDonald JW, Thau MR, Himmelfarb J, Goss CH, Aitken M, Kelly EJ, Bhatraju PK. Identification of prognostic biomarkers for antibiotic associated nephrotoxicity in cystic fibrosis. J Cyst Fibros. 2024 Mar; 23(2):293-299. PMID: 37949747.
      Citations:    
    15. Chang SY, Huang W, Chapron A, Qui?ones AJL, Wang J, Isoherranen N, Shen DD, Kelly EJ, Himmelfarb J, Yeung CK. Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease. Pharm Res. 2023 Nov; 40(11):2597-2606. PMID: 37704895.
      Citations:    
    16. Sun A, Hagenbuch B, Kelly EJ, Wang J. Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. Mol Pharmacol. 2023 Dec; 104(6):255-265. PMID: 37652713.
      Citations:    Fields:    Translation:HumansAnimals
    17. Kamine TH, Siu M, Kramer KZ, Alouidor R, Kelly E, Deutsch A, Mader TJ, Visintainer P, Grochowski K, Jabbour N. Feasibility and Acceptance of a Teletrauma Surgery Consult Service to Rural and Community Hospitals: A Pilot Study. J Am Coll Surg. 2023 01 01; 236(1):145-153. PMID: 36226848.
      Citations:    Fields:    Translation:Humans
    18. Siu M, Levin D, Christiansen R, Kelly E, Alouidor R, Kamine TH. Prophylactic Splenectomy and Hyposplenism in Spaceflight. Aerosp Med Hum Perform. 2022 Dec 01; 93(12):877-881. PMID: 36757247.
      Citations:    Fields:    Translation:Humans
    19. Levin DR, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Kamine T. Time Cost of Provider Skill: A Pilot Study of Medical Officer Occupied Time By Knowledge, Skill, and Ability Level. Aerosp Med Hum Perform. 2022 Nov 01; 93(11):816-821. PMID: 36309789.
      Citations:    Fields:    Translation:Humans
    20. Kamine TH, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Levin D. Spatial Volume Necessary to Perform Open Appendectomy in a Spacecraft. Aerosp Med Hum Perform. 2022 Oct 01; 93(10):760-763. PMID: 36243909.
      Citations:    Fields:    Translation:Humans
    21. Kirkendoll SD, Kelly E, Kramer K, Alouidor R, Winston E, Putnam T, Ryb G, Jabbour N, Perez Coulter A, Kamine T. Optimal Timing of Cholecystectomy for Acute Cholecystitis: A Retrospective Cohort Study. Cureus. 2022 Aug; 14(8):e28548. PMID: 36185866.
      Citations:    
    22. Kamine TH, Dhanani H, Wilcox S, Kelly E, Alouidor R, Kramer K, Carey Y, Ryb G, Putnam AT, Winston E, Cohen J. American Helicopter Emergency Medical Service Pilots Report to Work Despite High Rates of Sleepiness. Air Med J. 2022 Sep-Oct; 41(5):432-434. PMID: 36153138.
      Citations:    Fields:    Translation:Humans
    23. Mahadeo A, Yeung CK, Himmelfarb J, Kelly EJ. Kidney microphysiological models for nephrotoxicity assessment. Curr Opin Toxicol. 2022 Jun; 30. PMID: 35495549.
      Citations:    
    24. Lidberg KA, Muthusamy S, Adil M, Mahadeo A, Yang J, Patel RS, Wang L, Bammler TK, Reichel J, Yeung CK, Himmelfarb J, Kelly EJ, Akilesh S. Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury. J Am Soc Nephrol. 2022 05; 33(5):949-965. PMID: 35197326.
      Citations: 6     Fields:    Translation:HumansAnimals
    25. Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ. Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. Sci Rep. 2021 11 01; 11(1):21356. PMID: 34725352.
      Citations: 7     Fields:    Translation:HumansCells
    26. Arian CM, Imaoka T, Yang J, Kelly EJ, Thummel KE. Gutsy science: In vitro systems of the human intestine to model oral drug disposition. Pharmacol Ther. 2022 02; 230:107962. PMID: 34478775.
      Citations: 1     Fields:    Translation:Humans
    27. Van Ness KP, Cesar F, Yeung CK, Himmelfarb J, Kelly EJ. Microphysiological systems in absorption, distribution, metabolism, and elimination sciences. Clin Transl Sci. 2022 01; 15(1):9-42. PMID: 34378335.
      Citations: 5     Fields:    
    28. Kowalski JP, Pelletier RD, McDonald MG, Kelly EJ, Rettie AE. Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: ?-oxidation as a potential augmenting pathway for inhibition. Xenobiotica. 2021 Aug; 51(8):901-915. PMID: 33993844.
      Citations:    
    29. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Author Correction: Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 May 17; 11(1):10711. PMID: 34002000.
      Citations:    Fields:    
    30. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 02 25; 11(1):4722. PMID: 33633318.
      Citations: 3     Fields:    Translation:HumansCells
    31. Nieskens TTG, Persson M, Kelly EJ, Sj?gren AK. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity. Drug Metab Dispos. 2020 12; 48(12):1303-1311. PMID: 33020068.
      Citations: 11     Fields:    Translation:HumansCells
    32. Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B. Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human. Mol Pharm. 2020 11 02; 17(11):4114-4124. PMID: 32955894.
      Citations: 18     Fields:    Translation:Humans
    33. Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ. Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology. 2020 11; 444:152582. PMID: 32905824.
      Citations: 14     Fields:    Translation:HumansCells
    34. Zhang A, Li CY, Kelly EJ, Sheppard L, Cui JY. Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism. PLoS One. 2020; 15(2):e0224644. PMID: 32101552.
      Citations:    
    35. Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro. 2020 Mar; 63:104752. PMID: 31857146.
      Citations:    
    36. Patel RC, Stalter RM, Thomas KK, Tamraz B, Blue SW, Erikson DW, Kim CJ, Kelly EJ, Nanda K, Kourtis AP, Lingappa JR, Mugo N, Baeten JM, Scarsi KK. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS. 2019 11 01; 33(13):1995-2004. PMID: 31306173.
      Citations: 8     Fields:    Translation:Humans
    37. Lyu HG, Castillo-Angeles M, Bruno M, Cooper Z, Nehra D, Nitzschke SL, Askari R, Kelly E, Shimizu N, Riviello R, Salim A, Havens JM. Outcomes of a low-osmolar water-soluble contrast pathway in small bowel obstruction. J Trauma Acute Care Surg. 2019 09; 87(3):630-635. PMID: 31205220.
      Citations: 2     Fields:    Translation:Humans
    38. Maass C, Sorensen NB, Himmelfarb J, Kelly EJ, Stokes CL, Cirit M. Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System. CPT Pharmacometrics Syst Pharmacol. 2019 05; 8(5):316-325. PMID: 30869201.
      Citations:    
    39. Sachar M, Kelly EJ, Unadkat JD. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. AAPS J. 2019 03 27; 21(3):45. PMID: 30919109.
      Citations: 9     Fields:    Translation:HumansCells
    40. Taghavi S, Castillo-Angeles M, Uribe-Leitz T, Hirji S, Armand P, Nehra D, Cooper Z, Kelly E, Havens J, Haider A, Salim A, Askari R. Emergency general surgery procedures in hematopoietic stem cell transplant recipients. Am J Surg. 2019 11; 218(5):972-977. PMID: 30862354.
      Citations:    Fields:    Translation:HumansPHPublic Health
    41. Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. JCI Insight. 2018 12 20; 3(24). PMID: 30568031.
      Citations:    
    42. Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y. Reconstructing the Human Renal Vascular-Tubular Unit In Vitro. Adv Healthc Mater. 2018 12; 7(23):e1801120. PMID: 30379416.
      Citations:    
    43. Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS. A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. J Am Soc Nephrol. 2018 12; 29(12):2820-2833. PMID: 30361326.
      Citations:    
    44. Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I. Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Sci Rep. 2018 10 05; 8(1):14882. PMID: 30291268.
      Citations:    
    45. Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metab Dispos. 2018 11; 46(11):1692-1702. PMID: 30076203.
      Citations: 21     Fields:    Translation:HumansAnimals
    46. Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system ALTEX. 2018; 35(4):504-515. PMID: 29999169.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    47. Yorkgitis BK, Olufajo OA, Gurien LA, Kelly E, Salim A, Askari R. Risk factors for prolonged need for percutaneous endoscopic gastrostomy (PEG) tubes in adult trauma patients: Experience of a level 1 trauma. Surgery. 2018 12; 164(6):1259-1262. PMID: 29983158.
      Citations:    Fields:    Translation:Humans
    48. Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight. 2017 11 16; 2(22). PMID: 29202460.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    49. Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD. Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics. Drug Metab Dispos. 2018 02; 46(2):189-196. PMID: 29138286.
      Citations: 20     Fields:    Translation:Humans
    50. Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological Systems to Assess Nonclinical Toxicity. Curr Protoc Toxicol. 2017 Aug 04; 73:14.18.1-14.18.28. PMID: 28777442.
      Citations: 9     Fields:    Translation:Humans
    51. Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ. Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. Br J Ophthalmol. 2018 02; 102(2):187-194. PMID: 28698241.
      Citations: 9     Fields:    Translation:Humans
    52. Yorkgitis BK, Bryant EA, Brat GA, Kelly E, Askari R, Ra JH. Ultrasonography training and utilization in surgical critical care fellowships: a program director's survey. J Surg Res. 2017 10; 218:292-297. PMID: 28985864.
      Citations:    
    53. Weber EJ, Himmelfarb J, Kelly EJ. Concise Review: Current and Emerging Biomarkers of Nephrotoxicity. Curr Opin Toxicol. 2017 Jun; 4:16-21. PMID: 29057384.
      Citations:    
    54. Bedeir K, Seethala R, Kelly E. Extracorporeal life support in trauma: Worth the risks? A systematic review of published series. J Trauma Acute Care Surg. 2017 02; 82(2):400-406. PMID: 27779589.
      Citations:    
    55. Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicol In Vitro. 2017 Apr; 40:170-183. PMID: 28089783.
      Citations:    
    56. Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD. Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics. Drug Metab Dispos. 2016 12; 44(12):1920-1924. PMID: 27621205.
      Citations: 47     Fields:    Translation:HumansCells
    57. Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney Int. 2016 09; 90(3):627-37. PMID: 27521113.
      Citations: 86     Fields:    Translation:HumansCells
    58. Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys W, Hop CE, Kumer SC, Unadkat JD. Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug Metab Dispos. 2016 11; 44(11):1752-1758. PMID: 27543206.
      Citations: 44     Fields:    Translation:HumansCells
    59. Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metab Dispos. 2016 10; 44(10):1598-602. PMID: 27468999.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    60. Olufajo OA, Yorkgitis BK, Cooper Z, Rios-Diaz A, Metcalfe D, Havens JM, Kelly E, Haider AH, Gates JD, Salim A. How long should we fear? Long-term risk of venous thromboembolism in patients with traumatic brain injury. J Trauma Acute Care Surg. 2016 07; 81(1):71-8. PMID: 27015575.
      Citations: 2     Fields:    Translation:Humans
    61. Farooq M, Kelly EJ, Unadkat JD. CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug Metab Dispos. 2016 May; 44(5):750-7. PMID: 26965986.
      Citations: 10     Fields:    Translation:HumansCells
    62. Olufajo OA, Tulebaev S, Javedan H, Gates J, Wang J, Duarte M, Kelly E, Lilley E, Salim A, Cooper Z. Integrating Geriatric Consults into Routine Care of Older Trauma Patients: One-Year Experience of a Level I Trauma Center. J Am Coll Surg. 2016 06; 222(6):1029-35. PMID: 26968324.
      Citations: 22     Fields:    Translation:HumansCTClinical Trials
    63. Olufajo OA, Metcalfe D, Rios-Diaz A, Lilley E, Havens JM, Kelly E, Weissman JS, Haider AH, Salim A, Cooper Z. Does Hospital Experience Rather than Volume Improve Outcomes in Geriatric Trauma Patients? J Am Coll Surg. 2016 07; 223(1):32-40.e1. PMID: 27055588.
      Citations: 4     Fields:    Translation:Humans
    64. Havens JM, Do WS, Kaafarani H, Mesar T, Reznor G, Cooper Z, Askari R, Kelly E, Columbus AB, Gates JD, Haider AH, Salim A. Explaining the excess morbidity of emergency general surgery: packed red blood cell and fresh frozen plasma transfusion practices are associated with major complications in nonmassively transfused patients. Am J Surg. 2016 Apr; 211(4):656-663.e4. PMID: 26860622.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    65. Ryu RJ, Eyal S, Easterling TR, Caritis SN, Venkataraman R, Hankins G, Rytting E, Thummel K, Kelly EJ, Risler L, Phillips B, Honaker MT, Shen DD, Hebert MF. Pharmacokinetics of metoprolol during pregnancy and lactation. J Clin Pharmacol. 2016 May; 56(5):581-9. PMID: 26461463.
      Citations:    
    66. Cooper Z, Goel N, Gutnik L, Reznor G, Lilley E, Williams KJ, Salim A, Kelly E, Zinner MJ. How Many Midnights?: Admission Status for Elders With Small Bowel Obstruction. Ann Surg. 2015 Dec; 262(6):904-6. PMID: 26079913.
      Citations:    
    67. Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr; 27(4):1015-28. PMID: 26260164.
      Citations: 40     Fields:    Translation:HumansCells
    68. Kelly E, Kiemele ER, Reznor G, Havens JM, Cooper Z, Salim A. Trauma systems are associated with increased level 3 trauma centers. J Surg Res. 2015 Oct; 198(2):489-93. PMID: 25986210.
      Citations: 2     Fields:    
    69. Havens JM, Peetz AB, Do WS, Cooper Z, Kelly E, Askari R, Reznor G, Salim A. The excess morbidity and mortality of emergency general surgery. J Trauma Acute Care Surg. 2015 Feb; 78(2):306-11. PMID: 25757115.
      Citations: 105     Fields:    Translation:HumansPHPublic Health
    70. Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H. Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. Biochem J. 2015 Jan 01; 465(1):103-14. PMID: 25247810.
      Citations:    
    71. Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15; 92(4):690-700. PMID: 25450675.
      Citations: 15     Fields:    Translation:HumansCells
    72. Lockhart CM, Nakano M, Rettie AE, Kelly EJ. Generation and characterization of a murine model of Bietti crystalline dystrophy. Invest Ophthalmol Vis Sci. 2014 Aug 12; 55(9):5572-81. PMID: 25118264.
      Citations: 22     Fields:    Translation:Animals
    73. Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J. Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metab Dispos. 2013 Dec; 41(12):2225-32. PMID: 24101703.
      Citations: 34     Fields:    Translation:HumansAnimals
    74. van der Wilden GM, Velmahos GC, Joseph DK, Jacobs L, Debusk MG, Adams CA, Gross R, Burkott B, Agarwal S, Maung AA, Johnson DC, Gates J, Kelly E, Michaud Y, Charash WE, Winchell RJ, Desjardins SE, Rosenblatt MS, Gupta S, Gaeta M, Chang Y, de Moya MA. Successful nonoperative management of the most severe blunt renal injuries: a multicenter study of the research consortium of New England Centers for Trauma. JAMA Surg. 2013 Oct; 148(10):924-31. PMID: 23945834.
      Citations: 29     Fields:    Translation:Humans
    75. Topletz AR, Le HN, Lee N, Chapman JD, Kelly EJ, Wang J, Isoherranen N. Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy. Drug Metab Dispos. 2013 Feb; 41(2):312-9. PMID: 23150428.
      Citations: 10     Fields:    Translation:AnimalsCells
    76. Kelly E, Rogers SO. Graduate medical education in trauma/critical care and acute care surgery: defining goals for a new workforce. Surg Clin North Am. 2012 Aug; 92(4):1055-64, x. PMID: 22850162.
      Citations: 3     Fields:    
    77. Ho MT, Kelly EJ, Bodor M, Bui T, Kowdley KV, Ho RJ. Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects. Ann Hepatol. 2011 Jul-Sep; 10(3):327-32. PMID: 21677335.
      Citations: 2     Fields:    Translation:HumansCells
    78. Crouthamel MH, Kelly EJ, Ho RJ. Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers. Transgenic Res. 2012 Feb; 21(1):113-30. PMID: 21538071.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    79. Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy V, Rettie AE. Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Mol Interv. 2011 Apr; 11(2):124-32. PMID: 21540472.
      Citations: 22     Fields:    Translation:HumansAnimals
    80. Kelly E, Mathew J, Kohler JE, Blass AL, Soybel DI. Redistribution of labile plasma zinc during mild surgical stress in the rat. Transl Res. 2011 Mar; 157(3):139-49. PMID: 21316030.
      Citations:    
    81. Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GD, Clark SM, Risler L, Wang J, Kelly EJ, Shen DD, Hebert MF. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos. 2010 May; 38(5):833-40. PMID: 20118196.
      Citations: 75     Fields:    Translation:Humans
    82. Nakano M, Kelly EJ, Rettie AE. Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab Dispos. 2009 Nov; 37(11):2119-22. PMID: 19661213.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    83. Havens JM, Kelly E, Patel V. A 78-year-old man with an elevated hemidiaphragm following trauma. Chest. 2008 Dec; 134(6):1336-1339. PMID: 19059966.
      Citations:    Fields:    Translation:Humans
    84. Salama NN, Kelly EJ, Bui T, Ho RJ. The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice. J Pharm Sci. 2005 Jun; 94(6):1216-25. PMID: 15858856.
      Citations: 15     Fields:    Translation:Animals
    85. Bodor M, Kelly EJ, Ho RJ. Characterization of the human MDR1 gene. AAPS J. 2005 Feb 16; 7(1):E1-5. PMID: 16146331.
      Citations: 42     Fields:    Translation:HumansCells
    86. McConnachie LA, Bodor M, Phillips B, Kelly EJ, Shen DD, Ho RJ. An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number. Genet Test. 2004; 8(3):313-8. PMID: 15727256.
      Citations: 1     Fields:    Translation:Humans
    87. Hashmi S, Kelly E, Rogers SO, Gates J. Urinary tract infection in surgical patients. Am J Surg. 2003 Jul; 186(1):53-6. PMID: 12842750.
      Citations: 6     Fields:    Translation:Humans
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