SEC Translocation Channels
"SEC Translocation Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Universally conserved multiprotein complexes that form the protein transport channel of the general secretory (SEC) pathway. The SEC translocase is present in all bacteria, archaea, and eukaryotes. It is in the ENDOPLASMIC RETICULUM membrane of eukaryotic cells, in the THYLAKOID MEMBRANE in CHLOROPLASTS and in some protozoa in the INNER MITOCHONDRIAL MEMBRANE.
| Descriptor ID |
D000069816
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| MeSH Number(s) |
D05.500.890.625 D12.776.157.530.875 D12.776.543.585.875
|
| Concept/Terms |
SEC Translocation Channels- SEC Translocation Channels
- Channels, SEC Translocation
- Translocation Channels, SEC
- SEC Translocase
- Translocase, SEC
- SEC Translocons
- Translocons, SEC
- SEC Complexes
- Complexes, SEC
- SEC61 Protein
- Protein, SEC61
- Sec Protein Translocation Systems
SecYEG Translocon- SecYEG Translocon
- Translocon, SecYEG
- SecY Translocase
- Translocase, SecY
- SecYEG Protein Translocation System
- SecYEG Translocation Channels
- Channels, SecYEG Translocation
- Translocation Channels, SecYEG
- SecYEG Complexes
- Complexes, SecYEG
- SecYEG Complex
- Complex, SecYEG
SEC61 Translocon- SEC61 Translocon
- Translocon, SEC61
- SEC61 Translocation Channels
- Channels, SEC61 Translocation
- Translocation Channels, SEC61
- Sec61 Complex
- Complex, Sec61
- Sec61 Protein Translocation System
- SEC61 Translocase
- Translocase, SEC61
|
Below are MeSH descriptors whose meaning is more general than "SEC Translocation Channels".
Below are MeSH descriptors whose meaning is more specific than "SEC Translocation Channels".
This graph shows the total number of publications written about "SEC Translocation Channels" by people in this website by year, and whether "SEC Translocation Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "SEC Translocation Channels" by people in Profiles.
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Yi JK, Fujita H, Mandon EC, Gilmore R. Rapid inactivation of the yeast Sec complex selectively blocks transport of post-translationally translocated proteins. J Biol Chem. 2021 10; 297(4):101171.
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Mandon EC, Butova C, Lachapelle A, Gilmore R. Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations. J Biol Chem. 2018 08 31; 293(35):13662-13672.
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Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, F?rster F, Beckmann R. Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science. 2018 04 13; 360(6385):215-219.
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Shrimal S, Cherepanova NA, Gilmore R. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon. J Cell Biol. 2017 11 06; 216(11):3625-3638.
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Akopian D, Dalal K, Shen K, Duong F, Shan SO. SecYEG activates GTPases to drive the completion of cotranslational protein targeting. J Cell Biol. 2013 Feb 18; 200(4):397-405.
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Friedman JR, Dibenedetto JR, West M, Rowland AA, Voeltz GK. Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature. Mol Biol Cell. 2013 Apr; 24(7):1030-40.
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Trueman SF, Mandon EC, Gilmore R. A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function. J Cell Biol. 2012 Dec 10; 199(6):907-18.
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Gilmore R, Mandon EC. Understanding integration of a-helical membrane proteins: the next steps. Trends Biochem Sci. 2012 Aug; 37(8):303-8.
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Maki JL, Krishnan B, Gierasch LM. Using a low denaturant model to explore the conformational features of translocation-active SecA. Biochemistry. 2012 Feb 21; 51(7):1369-79.
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Trueman SF, Mandon EC, Gilmore R. Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity. Mol Biol Cell. 2011 Sep; 22(17):2983-93.