"APOBEC Deaminases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of conserved cytidine deaminases that catalyze the DEAMINATION of CYTIDINE to URIDINE. They are characterized by N and C-terminal zinc-dependent catalytic domains and have important functions in RNA EDITING; EPIGENTIC PROCESSES; and the INNATE IMMUNE RESPONSE against viruses.
| Descriptor ID |
D000071478
|
| MeSH Number(s) |
D08.811.277.151.486.250.500
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| Concept/Terms |
APOBEC Deaminases- APOBEC Deaminases
- Deaminases, APOBEC
- APOBEC Family Proteins
- APOBEC Enzymes
- Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptides
- AID-APOBEC Deaminases
- AID APOBEC Deaminases
- Deaminases, AID-APOBEC
|
Below are MeSH descriptors whose meaning is more general than "APOBEC Deaminases".
Below are MeSH descriptors whose meaning is more specific than "APOBEC Deaminases".
This graph shows the total number of publications written about "APOBEC Deaminases" by people in this website by year, and whether "APOBEC Deaminases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "APOBEC Deaminases" by people in Profiles.
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Hou S, Lee JM, Myint W, Matsuo H, Kurt Yilmaz N, Schiffer CA. Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s. J Biol Chem. 2021 08; 297(2):100909.
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Maiti A, Hou S, Schiffer CA, Matsuo H. Interactions of APOBEC3s with DNA and RNA. Curr Opin Struct Biol. 2021 04; 67:195-204.
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Silvas TV, Schiffer CA. APOBEC3s: DNA-editing human cytidine deaminases. Protein Sci. 2019 09; 28(9):1552-1566.
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Kim D, Luk K, Wolfe SA, Kim JS. Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases. Annu Rev Biochem. 2019 Jun 20; 88:191-220.
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Qin T, Zhang Y, Zarins KR, Jones TR, Virani S, Peterson LA, McHugh JB, Chepeha D, Wolf GT, Rozek LS, Sartor MA. Expressed HNSCC variants by HPV-status in a well-characterized Michigan cohort. Sci Rep. 2018 07 30; 8(1):11458.
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Shandilya SM, Bohn MF, Schiffer CA. A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif. Virology. 2014 Dec; 471-473:105-16.