"TWEAK Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor for TWEAK cytokine that is highly expressed by cells in the heart, placenta, and kidney. It plays a role in ANGIOGENESIS and the proliferation of endothelial cells; it may also modulate cellular adhesion to the extracellular matrix.
| Descriptor ID |
D000074050
|
| MeSH Number(s) |
D12.776.543.750.705.852.760.974
|
| Concept/Terms |
TWEAK Receptor- TWEAK Receptor
- Receptor, TWEAK
- Fn14 TWEAK Receptor
- Receptor, Fn14 TWEAK
- TWEAK Receptor, Fn14
- TWEAK Receptor Fn14
- Fn14, TWEAK Receptor
- Receptor Fn14, TWEAK
- Tumor Necrosis Factor-like Weak Inducer of Apoptosis Receptor
- Tumor Necrosis Factor like Weak Inducer of Apoptosis Receptor
- CD266 Antigen
- Antigen, CD266
- Tumor Necrosis Factor Receptor Superfamily, Member 12A
- TNF Receptor Superfamily Member 12A
- TWEAKR
- Fn14 Receptor
- Receptor, Fn14
|
Below are MeSH descriptors whose meaning is more general than "TWEAK Receptor".
Below are MeSH descriptors whose meaning is more specific than "TWEAK Receptor".
This graph shows the total number of publications written about "TWEAK Receptor" by people in this website by year, and whether "TWEAK Receptor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "TWEAK Receptor" by people in Profiles.
-
Lam ET, Eckhardt SG, Messersmith W, Jimeno A, O'Bryant CL, Ramanathan RK, Weiss GJ, Chadha M, Oey A, Ding HT, Culp PA, Keller SF, Zhao VY, Tsao LC, Singhal A, Holen KD, Von Hoff D. Phase I Study of Enavatuzumab, a First-in-Class Humanized Monoclonal Antibody Targeting the TWEAK Receptor, in Patients with Advanced Solid Tumors. Mol Cancer Ther. 2018 01; 17(1):215-221.
-
Whitsett TG, Fortin Ensign SP, Dhruv HD, Inge LJ, Kurywchak P, Wolf KK, LoBello J, Kingsley CB, Allen JW, Weiss GJ, Tran NL. FN14 expression correlates with MET in NSCLC and promotes MET-driven cell invasion. Clin Exp Metastasis. 2014 Aug; 31(6):613-23.
-
Whitsett TG, Mathews IT, Cardone MH, Lena RJ, Pierceall WE, Bittner M, Sima C, LoBello J, Weiss GJ, Tran NL. Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response. Mol Cancer Res. 2014 Apr; 12(4):550-9.
-
Whitsett TG, Cheng E, Inge L, Asrani K, Jameson NM, Hostetter G, Weiss GJ, Kingsley CB, Loftus JC, Bremner R, Tran NL, Winkles JA. Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Am J Pathol. 2012 Jul; 181(1):111-20.
-
Girgenrath M, Weng S, Kostek CA, Browning B, Wang M, Brown SA, Winkles JA, Michaelson JS, Allaire N, Schneider P, Scott ML, Hsu YM, Yagita H, Flavell RA, Miller JB, Burkly LC, Zheng TS. TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J. 2006 Dec 13; 25(24):5826-39.