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Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons.

Rojas F, Aguilar R, Almeida S, Fritz E, Corval?n D, Ampuero E, Abarz?a S, Garc?s P, Amaro A, Diaz I, Arredondo C, Cortes N, Sanchez M, Mercado C, Varela-Nallar L, Gao FB, Montecino M, van Zundert B. Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons. Front Cell Dev Biol. 2023; 11:1226604.

View in: PubMed