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Johannes Elferich PhD

TitleInstructor
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressHoward Hughes Medical Institute
368 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute


    Collapse Biography 
    Collapse education and training
    Technical University of Munich, Munich, , GermanyBSMolecular Biotechnology
    Oregon Health Science University, Portland, OR, United StatesPHDBiochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Elferich J, Kong L, Zottig X, Grigorieff N. CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples. Elife. 2024 Dec 20; 13. PMID: 39704651.
      Citations:    
    2. Matsui A, Spangler C, Elferich J, Shiozaki M, Jean N, Zhao X, Qin M, Zhong H, Yu Z, Gouaux E. Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses. Elife. 2024 Nov 04; 13. PMID: 39495821.
      Citations:    
    3. Clark S, Mitra J, Elferich J, Goehring A, Ge J, Ha T, Gouaux E. Single molecule studies of the native hair cell mechanosensory transduction complex. bioRxiv. 2023 Dec 12. PMID: 38168376.
      Citations:    
    4. Elferich J, Schiroli G, Scadden DT, Grigorieff N. Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections. Elife. 2022 11 16; 11. PMID: 36382886.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Elferich J, Clark S, Ge J, Goehring A, Matsui A, Gouaux E. Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography. Elife. 2021 12 29; 10. PMID: 34964715.
      Citations:    
    6. Holt JR, Tobin M, Elferich J, Gouaux E, Ballesteros A, Yan Z, Ahmed ZM, Nicolson T. Putting the Pieces Together: the Hair Cell Transduction Complex. J Assoc Res Otolaryngol. 2021 12; 22(6):601-608. PMID: 34617206.
      Citations:    
    7. Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E. Molecular mechanism of prestin electromotive signal amplification. Cell. 2021 09 02; 184(18):4669-4679.e13. PMID: 34390643.
      Citations:    
    8. Clark S, Elferich J, Gai J, Goehring A, Mitra J, Ha T, Gouaux E. Strategy for Compositional Analysis of the Hair Cell Mechanotransduction Complex Using TIRF Microscopy. Microsc Microanal. 2019 08; 25(Suppl 2):1266-1267. PMID: 32025193.
      Citations:    
    9. Elferich J, Posert R, Yoshioka C, Gouaux E. HOTSPUR: A Real-time Interactive Preprocessing System for Cryo-EM Data. Microsc Microanal. 2019 08; 25(Suppl 2):1212-1213. PMID: 32038096.
      Citations:    
    10. Ge J, Elferich J, Goehring A, Zhao H, Schuck P, Gouaux E. Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5. Elife. 2018 08 02; 7. PMID: 30070639.
      Citations:    
    11. Hosseini MM, Kurtz SE, Abdelhamed S, Mahmood S, Davare MA, Kaempf A, Elferich J, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JW, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. Leukemia. 2018 11; 32(11):2374-2387. PMID: 29743719.
      Citations:    
    12. Garbati MR, Welgan CA, Landefeld SH, Newell LF, Agarwal A, Dunlap JB, Chourasia TK, Lee H, Elferich J, Traer E, Rattray R, Cascio MJ, Press RD, Bagby GC, Tyner JW, Druker BJ, Dao KH. Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism. Am J Hematol. 2016 Feb; 91(2):211-9. PMID: 26573090.
      Citations:    
    13. Williamson DM, Elferich J, Shinde U. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3. J Biol Chem. 2015 Sep 18; 290(38):23214-25. PMID: 26229104.
      Citations:    
    14. Elferich J, Williamson DM, David LL, Shinde U. Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry. Anal Chem. 2015 Aug 04; 87(15):7909-17. PMID: 26110992.
      Citations:    
    15. Conti BJ, Elferich J, Yang Z, Shinde U, Skach WR. Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex. Nat Struct Mol Biol. 2014 Mar; 21(3):228-35. PMID: 24561504.
      Citations:    
    16. Vald?s R, Elferich J, Shinde U, Landfear SM. Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family. J Biol Chem. 2014 Mar 28; 289(13):8799-809. PMID: 24497645.
      Citations:    
    17. Li Y, Sun XX, Elferich J, Shinde U, David LL, Dai MS. Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein. J Biol Chem. 2014 Feb 21; 289(8):5097-108. PMID: 24403071.
      Citations:    
    18. Davare MA, Saborowski A, Eide CA, Tognon C, Smith RL, Elferich J, Agarwal A, Tyner JW, Shinde UP, Lowe SW, Druker BJ. Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19519-24. PMID: 24218589.
      Citations:    
    19. Soysa R, Wilson ZN, Elferich J, Forquer I, Shinde U, Riscoe MK, Yates PA, Ullman B. Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs. J Biol Chem. 2013 Oct 11; 288(41):29954-64. PMID: 23986453.
      Citations:    
    20. Tran KD, Rodriguez-Contreras D, Vieira DP, Yates PA, David L, Beatty W, Elferich J, Landfear SM. KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes. J Biol Chem. 2013 Aug 02; 288(31):22721-33. PMID: 23766511.
      Citations:    
    21. Nili M, David L, Elferich J, Shinde U, Rotwein P. Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c. Biochem J. 2013 May 15; 452(1):87-95. PMID: 23464809.
      Citations:    
    22. Williamson DM, Elferich J, Ramakrishnan P, Thomas G, Shinde U. The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin. J Biol Chem. 2013 Jun 28; 288(26):19154-65. PMID: 23653353.
      Citations:    
    23. Elferich J, Williamson DM, Krishnamoorthy B, Shinde U. Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation. FASEB J. 2013 Aug; 27(8):2939-45. PMID: 23585398.
      Citations:    
    24. Marcinowski M, Rosam M, Seitz C, Elferich J, Behnke J, Bello C, Feige MJ, Becker CF, Antes I, Buchner J. Conformational selection in substrate recognition by Hsp70 chaperones. J Mol Biol. 2013 Feb 08; 425(3):466-74. PMID: 23207294.
      Citations:    
    25. Dillon SL, Williamson DM, Elferich J, Radler D, Joshi R, Thomas G, Shinde U. Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol. 2012 Oct 12; 423(1):47-62. PMID: 22743102.
      Citations:    
    26. Dikeakos JD, Thomas L, Kwon G, Elferich J, Shinde U, Thomas G. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Mol Biol Cell. 2012 Jun; 23(11):2184-97. PMID: 22496420.
      Citations:    
    27. Wang H, Elferich J, Gouaux E. Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol. 2012 Jan 15; 19(2):212-9. PMID: 22245965.
      Citations:    
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