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C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.Academic Article Why?
Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD.Academic Article Why?
The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD.Academic Article Why?
How villains are made: The translation of dipeptide repeat proteins in C9ORF72-ALS/FTD.Academic Article Why?
Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.Academic Article Why?
Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons.Academic Article Why?
Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models.Academic Article Why?
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data.Academic Article Why?
Gao, Fen-BiaoPerson Why?
Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features.Academic Article Why?
C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys.Academic Article Why?
Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.Academic Article Why?
A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.Academic Article Why?
Translation of the poly(GR) frame in C9ORF72-ALS/FTD is regulated by cis-elements involved in alternative splicing.Academic Article Why?
Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.Academic Article Why?
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