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Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Leukoencephalopathies
How villains are made: The translation of dipeptide repeat proteins in C9ORF72-ALS/FTD.
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How villains are made: The translation of dipeptide repeat proteins in C9ORF72-ALS/FTD.
Van't Spijker HM, Almeida S. How villains are made: The translation of dipeptide repeat proteins in C9ORF72-ALS/FTD. Gene. 2023 Mar 30; 858:147167.
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PubMed
subject areas
Amyotrophic Lateral Sclerosis
Animals
C9orf72 Protein
Dipeptides
DNA Repeat Expansion
Frontotemporal Dementia
Proteins
RNA
authors with profiles
Sandra Cristina Vicente Almeida PhD