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    David R Weaver PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurobiology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB-723
    Worcester MA 01605
    Phone508-856-2495
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative

        Academic Background

        B.S., Michigan State University1981
        Ph.D., Michigan State University1985
        Postdoctoral Research Fellow, Mass. General Hospital1985-1987
        Postdoctoral Research Fellow, Harvard Medical School1985-1987
        Assistant in Neurobiology, Massachusetts General Hospital1987-1992
        Instructor, Harvard Medical School1987-1989
        Assistant Professor, Harvard Medical School1989-1994
        Associate Neurobiologist, Massachusetts General Hospital1993-2001
        Associate Professor, Harvard Medical School1994-2001
        Associate Professor, UMass Medical School2001-2006
        Director, Graduate Program in Neuroscience, UMass Medical School2005-
        Professor, UMass Medical School2006-

        Research Program Description: Molecular Physiology of Circadian Rhythms

        The major objective of our research program is to understand the molecular mechanisms for circadian rhythmicity, and the impact of circadian rhythms on physiology and behavior.

        Molecular mechanisms of circadian rhythmicity.

        Daily rhythms in activity levels, alertness/sleep, body temperature, and hormonal profiles will persist in constant conditions, with a cycle length of about 24 hours, demonstrating the presence of an internal time-keeping system. When exposed to a daily light-dark cycle, these rhythms are synchronized (entrained) to a 24-hour period. In mammals, a small area of the anterior hypothalamus called the suprachiasmatic nucleus (SCN) is the principal circadian pacemaker (for review see Weaver, 1998; Reppert & Weaver 2001).

        How do SCN neurons measure out 24 hours? Work on the circadian clocks of species ranging from bacteria to fungi to fruit flies has revealed a common thread, that the molecular basis for circadian rhythmicity is the rhythmic synthesis of "clock" molecules. In each of these species, and in mammals, molecules are synthesized rhythmically, and these molecules then feed back to turn off their own synthesis. This forms what is called a "transcriptional-translational feedback loop." Mutations of specific genes within the feedback loop result in altered or disrupted rhythmicity. Recently, great advances have been made in identifying the components of the circadian feedback loop in mammals, and in defining the specific roles of individual gene products in the circadian clock (reviewed in Reppert & Weaver 2002). The aim of this research is to understand the molecular mechanisms underlying generation and entrainment of circadian rhythms in mammals.

        Current Research Projects:

        We are studying behavioral and molecular phenotypes of mice with genetic defects altering circadian behavior. We continue to generate line of mice with targeted disruption of genes relevant to circadian rhythms. Other areas of interest are to identify the effects of clock gene mutations on other behavioral and physiological processes, including sleep, and to understand the importance of local oscillators in tissues outside the brain.

        Please use the Publications Tab at the top of this page for the most up-to-date description of this research program and my collaborators.



        Rotation Projects

        Rotation Projects Available (2013)

        The main focus of the lab is to understand the molecular mechanisms and physiological consequences of circadian (24-hour) rhythmicity, using the mouse as a model organism.  Depending on specific interests, students can work on rotation projects in areas ranging from molecular, biochemical, physiological through behavioral levels of analysis.  

        Current projects focus on:

        (1) the effects of disrupting genes in site-specific patterns, on circadian rhythms and physiology. This project involves characterizing the efficacy of Cre-mediated gene expression in various tissues, assessing circadian function in mice, tissue explants, and cultured cells, and examining physiological effects of gene disruption events.

        (2) "non-circadian" effects of disruption of circadian clock genes.  Current focus is on reproductive and arthropathy phenotypes. 

        For more specific information, make an appointment to speak with me.

         



        Post Docs

        A postdoctoral position will be available beginning in 2013.  Submit CV by email along with a cover letter indicating your areas of interest and date available.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Punia S, Rumery KK, Yu EA, Lambert CM, Notkins AL, Weaver DR. Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2ß. Am J Physiol Endocrinol Metab. 2012 Sep; 303(6):E762-76.
          View in: PubMed
        2. Zhu H, Vadigepalli R, Rafferty R, Gonye GE, Weaver DR, Schwaber JS. Integrative gene regulatory network analysis reveals light-induced regional gene expression phase shift programs in the mouse suprachiasmatic nucleus. PLoS One. 2012; 7(5):e37833.
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        3. Lesauter J, Lambert CM, Robotham MR, Model Z, Silver R, Weaver DR. Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus. PLoS One. 2012; 7(4):e35938.
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        4. Schwartz WJ, Tavakoli-Nezhad M, Lambert CM, Weaver DR, de la Iglesia HO. Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17219-24.
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        5. Dallmann R, Debruyne JP, Weaver DR. Photic Resetting and Entrainment in CLOCK-Deficient Mice. J Biol Rhythms. 2011 Oct; 26(5):390-401.
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        6. Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR, Lee C. The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16451-6.
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        7. Yu EA, Weaver DR. Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany NY). 2011 May; 3(5):479-93.
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        8. Dallmann R, Weaver DR. Altered body mass regulation in male mPeriod mutant mice on high-fat diet. Chronobiol Int. 2010 Jul; 27(6):1317-28.
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        9. Etchegaray JP, Yu EA, Indic P, Dallmann R, Weaver DR. Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One. 2010; 5(4):e10303.
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        10. Gumz ML, Stow LR, Lynch IJ, Greenlee MM, Rudin A, Cain BD, Weaver DR, Wingo CS. The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice. J Clin Invest. 2009 Aug; 119(8):2423-34.
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        11. Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL. Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity. FASEB J. 2009 Sep; 23(9):3226-32.
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        12. Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul; 29(14):3853-66.
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        13. Keaney JF, Weaver DR. Vascular rhythms and adaptation: do your arteries know what time it is? Circulation. 2009 Mar 24; 119(11):1463-6.
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        14. Yasuo S, von Gall C, Weaver DR, Korf HW. Rhythmic expression of clock genes in the ependymal cell layer of the third ventricle of rodents is independent of melatonin signaling. Eur J Neurosci. 2008 Dec; 28(12):2443-50.
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        15. DeBruyne JP, Weaver DR, Reppert SM. Peripheral circadian oscillators require CLOCK. Curr Biol. 2007 Jul 17; 17(14):R538-9.
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        16. DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May; 10(5):543-5.
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        17. Tavakoli-Nezhad M, Tao-Cheng JH, Weaver DR, Schwartz WJ. PER1-like immunoreactivity in oxytocin cells of the hamster hypothalamo-neurohypophyseal system. J Biol Rhythms. 2007 Feb; 22(1):81-4.
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        18. Bae K, Weaver DR. Transient, light-induced rhythmicity in mPer-deficient mice. J Biol Rhythms. 2007 Feb; 22(1):85-8.
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        19. von Gall C, Weaver DR. Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus. Neurobiol Aging. 2008 Mar; 29(3):464-70.
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        20. Etchegaray JP, Yang X, DeBruyne JP, Peters AH, Weaver DR, Jenuwein T, Reppert SM. The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28; 281(30):21209-15.
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        21. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 4; 50(3):465-77.
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        22. Lambert CM, Weaver DR. Peripheral gene expression rhythms in a diurnal rodent. J Biol Rhythms. 2006 Feb; 21(1):77-9.
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        23. Jilg A, Moek J, Weaver DR, Korf HW, Stehle JH, von Gall C. Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling. Eur J Neurosci. 2005 Dec; 22(11):2845-54.
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        24. Wang LM, Suthana NA, Chaudhury D, Weaver DR, Colwell CS. Melatonin inhibits hippocampal long-term potentiation. Eur J Neurosci. 2005 Nov; 22(9):2231-7.
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        25. Lambert CM, Machida KK, Smale L, Nunez AA, Weaver DR. Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus). J Biol Rhythms. 2005 Jun; 20(3):206-18.
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        26. von Gall C, Weaver DR, Moek J, Jilg A, Stehle JH, Korf HW. Melatonin plays a crucial role in the regulation of rhythmic clock gene expression in the mouse pars tuberalis. Ann N Y Acad Sci. 2005 Apr; 1040:508-11.
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        27. Shiromani PJ, Xu M, Winston EM, Shiromani SN, Gerashchenko D, Weaver DR. Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes. Am J Physiol Regul Integr Comp Physiol. 2004 Jul; 287(1):R47-57.
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        28. Lee C, Weaver DR, Reppert SM. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan; 24(2):584-94.
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        29. von Gall C, Noton E, Lee C, Weaver DR. Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus. Eur J Neurosci. 2003 Jul; 18(1):125-33.
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        30. Bae K, Weaver DR. Light-induced phase shifts in mice lacking mPER1 or mPER2. J Biol Rhythms. 2003 Apr; 18(2):123-33.
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        31. Olcese J, Domagalski R, Bednorz A, Weaver DR, Urbanski HF, Reuss S, Middendorff R. Expression and regulation of mPer1 in immortalized GnRH neurons. Neuroreport. 2003 Mar 24; 14(4):613-8.
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        32. Jin X, von Gall C, Pieschl RL, Gribkoff VK, Stehle JH, Reppert SM, Weaver DR. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol. 2003 Feb; 23(3):1054-60.
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        33. Forger DB, Dean DA, Gurdziel K, Leloup JC, Lee C, Von Gall C, Etchegaray JP, Kronauer RE, Goldbeter A, Peskin CS, Jewett ME, Weaver DR. Development and validation of computational models for mammalian circadian oscillators. OMICS. 2003; 7(4):387-400.
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        34. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002 Aug 29; 418(6901):935-41.
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        35. Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002 May 23; 417(6887):405-10.
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        36. von Gall C, Stehle JH, Weaver DR. Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res. 2002 Jul; 309(1):151-62.
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        37. von Gall C, Garabette ML, Kell CA, Frenzel S, Dehghani F, Schumm-Draeger PM, Weaver DR, Korf HW, Hastings MH, Stehle JH. Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nat Neurosci. 2002 Mar; 5(3):234-8.
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        38. Shearman LP, Weaver DR. Distinct pharmacological mechanisms leading to c-fos gene expression in the fetal suprachiasmatic nucleus. J Biol Rhythms. 2001 Dec; 16(6):531-40.
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        39. Weaver DR, Capodice CE. Postmortem stability of melatonin receptor binding and clock-relevant mRNAs in mouse suprachiasmatic nucleus. J Biol Rhythms. 2001 Jun; 16(3):216-23.
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        40. Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron. 2001 May; 30(2):525-36.
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        41. Reppert SM, Weaver DR. Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol. 2001; 63:647-76.
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        42. Reppert SM, Weaver DR. Comparing clockworks: mouse versus fly. J Biol Rhythms. 2000 Oct; 15(5):357-64.
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        43. Shearman LP, Jin X, Lee C, Reppert SM, Weaver DR. Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol. 2000 Sep; 20(17):6269-75.
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        44. Gotter AL, Manganaro T, Weaver DR, Kolakowski LF, Possidente B, Sriram S, MacLaughlin DT, Reppert SM. A time-less function for mouse timeless. Nat Neurosci. 2000 Aug; 3(8):755-6.
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        45. von Gall C, Weaver DR, Kock M, Korf HW, Stehle JH. Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptor. Neuroreport. 2000 Jun 26; 11(9):1803-7.
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        46. Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, Reppert SM. Interacting molecular loops in the mammalian circadian clock. Science. 2000 May 12; 288(5468):1013-9.
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        47. Field MD, Maywood ES, O'Brien JA, Weaver DR, Reppert SM, Hastings MH. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms. Neuron. 2000 Feb; 25(2):437-47.
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        48. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 1999 Jul 23; 98(2):193-205.
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        49. Hastings MH, Field MD, Maywood ES, Weaver DR, Reppert SM. Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism. J Neurosci. 1999 Jun 15; 19(12):RC11.
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        50. Shearman LP, Zylka MJ, Reppert SM, Weaver DR. Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus. Neuroscience. 1999 Mar; 89(2):387-97.
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        51. Shearman LP, Weaver DR. Photic induction of Period gene expression is reduced in Clock mutant mice. Neuroreport. 1999 Feb 25; 10(3):613-8.
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        52. Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 1999 Jan 8; 96(1):57-68.
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        53. Weaver DR. The roles of melatonin in development. Adv Exp Med Biol. 1999; 460:199-214.
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        54. Zylka MJ, Shearman LP, Levine JD, Jin X, Weaver DR, Reppert SM. Molecular analysis of mammalian timeless. Neuron. 1998 Nov; 21(5):1115-22.
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        55. Zylka MJ, Shearman LP, Weaver DR, Reppert SM. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron. 1998 Jun; 20(6):1103-10.
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        56. Weaver DR. The suprachiasmatic nucleus: a 25-year retrospective. J Biol Rhythms. 1998 Apr; 13(2):100-12.
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        57. Liu C, Weaver DR, Strogatz SH, Reppert SM. Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei. Cell. 1997 Dec 12; 91(6):855-60.
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        58. Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. 1997 Dec; 19(6):1261-9.
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        59. Weaver DR. Reproductive safety of melatonin: a "wonder drug" to wonder about. J Biol Rhythms. 1997 Dec; 12(6):682-9.
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        60. Shearman LP, Zeitzer J, Weaver DR. Widespread expression of functional D1-dopamine receptors in fetal rat brain. Brain Res Dev Brain Res. 1997 Aug 18; 102(1):105-15.
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        61. Shearman LP, Weaver DR. Haloperidol regulates neurotensin gene expression in striatum of c-fos-deficient mice. Brain Res Mol Brain Res. 1997 Jul; 47(1-2):275-85.
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        62. Liu C, Weaver DR, Jin X, Shearman LP, Pieschl RL, Gribkoff VK, Reppert SM. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron. 1997 Jul; 19(1):91-102.
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        63. Reppert SM, Weaver DR. Forward genetic approach strikes gold: cloning of a mammalian clock gene. Cell. 1997 May 16; 89(4):487-90.
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        64. Shearman LP, Weaver DR. [125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptor subtypes in rat brain. Brain Res. 1997 Jan 16; 745(1-2):10-20.
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        65. Weaver DR, Reppert SM. The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei. Neuroreport. 1996 Dec 20; 8(1):109-12.
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        66. Weaver DR, Liu C, Reppert SM. Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov; 10(11):1478-87.
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        67. Roca AL, Godson C, Weaver DR, Reppert SM. Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor. Endocrinology. 1996 Aug; 137(8):3469-77.
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        68. Weaver DR. A1-adenosine receptor gene expression in fetal rat brain. Brain Res Dev Brain Res. 1996 Jul 20; 94(2):205-23.
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        69. Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF. Cloning of a melatonin-related receptor from human pituitary. FEBS Lett. 1996 May 20; 386(2-3):219-24.
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        70. Reppert SM, Weaver DR, Godson C. Melatonin receptors step into the light: cloning and classification of subtypes. Trends Pharmacol Sci. 1996 Mar; 17(3):100-2.
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        71. Reppert SM, Weaver DR. Melatonin madness. Cell. 1995 Dec 29; 83(7):1059-62.
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        72. Reppert SM, Weaver DR, Cassone VM, Godson C, Kolakowski LF. Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain. Neuron. 1995 Nov; 15(5):1003-15.
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        73. Weaver DR, Reppert SM. Definition of the developmental transition from dopaminergic to photic regulation of c-fos gene expression in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 1995 Oct; 33(1):136-48.
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        74. Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8734-8.
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        75. Weaver DR, Roca AL, Reppert SM. c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation. Brain Res Dev Brain Res. 1995 Apr 18; 85(2):293-7.
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        76. Weaver DR, Deeds JD, Lee K, Segre GV. Localization of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor mRNAs in rat brain. Brain Res Mol Brain Res. 1995 Feb; 28(2):296-310.
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        77. Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron. 1994 Nov; 13(5):1177-85.
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        78. Viswanathan N, Weaver DR, Reppert SM, Davis FC. Entrainment of the fetal hamster circadian pacemaker by prenatal injections of the dopamine agonist SKF 38393. J Neurosci. 1994 Sep; 14(9):5393-8.
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        79. Weaver DR. A2a adenosine receptor gene expression in developing rat brain. Brain Res Mol Brain Res. 1993 Dec; 20(4):313-27.
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        80. Roca AL, Weaver DR, Reppert SM. Serotonin receptor gene expression in the rat suprachiasmatic nuclei. Brain Res. 1993 Apr 9; 608(1):159-65.
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        81. Weaver DR, Stehle JH, Stopa EG, Reppert SM. Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin. J Clin Endocrinol Metab. 1993 Feb; 76(2):295-301.
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        82. Rivkees SA, Weaver DR, Reppert SM. Circadian and developmental regulation of Oct-2 gene expression in the suprachiasmatic nuclei. Brain Res. 1992 Dec 11; 598(1-2):332-6.
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        83. Weaver DR, Reppert SM. Adenosine receptor gene expression in rat kidney. Am J Physiol. 1992 Dec; 263(6 Pt 2):F991-5.
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        84. Weaver DR, Rivkees SA, Reppert SM. D1-dopamine receptors activate c-fos expression in the fetal suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19):9201-4.
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        85. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res. 1992 Jul; 14(3):186-95.
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        86. Reppert SM, Weaver DR, Stehle JH, Rivkees SA, Grabbe S, Granstein RD. Molecular cloning of a G protein-coupled receptor that is highly expressed in lymphocytes and proliferative areas of developing brain. Mol Cell Neurosci. 1992 Jun; 3(3):206-14.
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        87. Stehle JH, Rivkees SA, Lee JJ, Weaver DR, Deeds JD, Reppert SM. Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol. 1992 Mar; 6(3):384-93.
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        88. Reppert SM, Weaver DR, Stehle JH, Rivkees SA. Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cord. Mol Endocrinol. 1991 Aug; 5(8):1037-48.
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        89. Carlson LL, Weaver DR, Reppert SM. Melatonin receptors and signal transduction during development in Siberian hamsters (Phodopus sungorus). Brain Res Dev Brain Res. 1991 Mar 18; 59(1):83-8.
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        90. Weaver DR, Provencio I, Carlson LL, Reppert SM. Melatonin receptors and signal transduction in photorefractory Siberian hamsters (Phodopus sungorus). Endocrinology. 1991 Feb; 128(2):1086-92.
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        91. Bittman EL, Weaver DR. The distribution of melatonin binding sites in neuroendocrine tissues of the ewe. Biol Reprod. 1990 Dec; 43(6):986-93.
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        92. Weaver DR, Reppert SM. Melatonin receptors are present in the ferret pars tuberalis and pars distalis, but not in brain. Endocrinology. 1990 Nov; 127(5):2607-9.
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        93. Weaver DR, Carlson LL, Reppert SM. Melatonin receptors and signal transduction in melatonin-sensitive and melatonin-insensitive populations of white-footed mice (Peromyscus leucopus). Brain Res. 1990 Jan 8; 506(2):353-7.
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        94. Carlson LL, Weaver DR, Reppert SM. Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Endocrinology. 1989 Nov; 125(5):2670-6.
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        95. Rivkees SA, Cassone VM, Weaver DR, Reppert SM. Melatonin receptors in chick brain: characterization and localization. Endocrinology. 1989 Jul; 125(1):363-8.
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        96. Weaver DR, Rivkees SA, Reppert SM. Localization and characterization of melatonin receptors in rodent brain by in vitro autoradiography. J Neurosci. 1989 Jul; 9(7):2581-90.
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        97. Weaver DR, Reppert SM. Direct in utero perception of light by the mammalian fetus. Brain Res Dev Brain Res. 1989 May 1; 47(1):151-5.
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        98. Weaver DR, Reppert SM. Periodic feeding of SCN-lesioned pregnant rats entrains the fetal biological clock. Brain Res Dev Brain Res. 1989 Apr 1; 46(2):291-6.
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        99. Reppert SM, Weaver DR, Rivkees SA, Stopa EG. Putative melatonin receptors in a human biological clock. Science. 1988 Oct 7; 242(4875):78-81.
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        100. Rivkees SA, Hall DA, Weaver DR, Reppert SM. Djungarian hamsters exhibit reproductive responses to changes in daylength at extreme photoperiods. Endocrinology. 1988 Jun; 122(6):2634-8.
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        101. Weaver DR, Namboodiri MA, Reppert SM. Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain. FEBS Lett. 1988 Feb 8; 228(1):123-7.
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        102. Clemens LG, Wee BE, Weaver DR, Roy EJ, Goldman BD, Rakerd B. Retention of masculine sexual behavior following castration in male B6D2F1 mice. Physiol Behav. 1988; 42(1):69-76.
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        103. Wee BE, Weaver DR, Clemens LG. Hormonal restoration of masculine sexual behavior in long-term castrated B6D2F1 mice. Physiol Behav. 1988; 42(1):77-82.
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        104. Reppert SM, Weaver DR, Rivkees SA. Maternal communication of circadian phase to the developing mammal. Psychoneuroendocrinology. 1988; 13(1-2):63-78.
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        105. Weaver DR, Keohan JT, Reppert SM. Definition of a prenatal sensitive period for maternal-fetal communication of day length. Am J Physiol. 1987 Dec; 253(6 Pt 1):E701-4.
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        106. Weaver DR, Reppert SM. Maternal-fetal communication of circadian phase in a precocious rodent, the spiny mouse. Am J Physiol. 1987 Oct; 253(4 Pt 1):E401-9.
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        107. Jacques SL, Weaver DR, Reppert SM. Penetration of light into the uterus of pregnant animals. Photochem Photobiol. 1987 May; 45(5):637-41.
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        108. Reppert SM, Henshaw D, Schwartz WJ, Weaver DR. The circadian-gated timing of birth in rats: disruption by maternal SCN lesions or by removal of the fetal brain. Brain Res. 1987 Feb 17; 403(2):398-402.
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        109. Weaver DR, Clemens LG. Nicotinic cholinergic influences on sexual receptivity in female rats. Pharmacol Biochem Behav. 1987 Feb; 26(2):393-400.
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        110. Weaver DR, Reppert SM. Maternal melatonin communicates daylength to the fetus in Djungarian hamsters. Endocrinology. 1986 Dec; 119(6):2861-3.
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        111. Dohanich GP, Witcher JA, Weaver DR, Clemens LG. Alteration of muscarinic binding in specific brain areas following estrogen treatment. Brain Res. 1982 Jun 10; 241(2):347-50.
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