Inactivation, Metabolic

"Inactivation, Metabolic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.

Descriptor ID	D008658
MeSH Number(s)	G03.171.450 G03.787.225.450 G07.690.725.225.450
Concept/Terms	Inactivation, Metabolic Inactivation, Metabolic Metabolic Inactivation Metabolic Detoxication, Drug Metabolic Detoxication, Drug Detoxication, Drug Metabolic Drug Metabolic Detoxication Drug Detoxication, Metabolic Detoxication, Metabolic Drug Metabolic Drug Detoxication Metabolic Detoxification, Drug Detoxification, Drug Metabolic Drug Metabolic Detoxification Detoxification, Drug, Metabolic Detoxication, Drug, Metabolic Metabolic Drug Inactivation Metabolic Drug Inactivation Drug Inactivation, Metabolic Inactivation, Metabolic Drug

Below are MeSH descriptors whose meaning is more general than "Inactivation, Metabolic".

Biological Sciences [G]
Metabolism [G03]
Biotransformation [G03.171]
Inactivation, Metabolic [G03.171.450]
Pharmacokinetics [G03.787]
Biotransformation [G03.787.225]
Inactivation, Metabolic [G03.787.225.450]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacokinetics [G07.690.725]
Biotransformation [G07.690.725.225]
Inactivation, Metabolic [G07.690.725.225.450]

Below are MeSH descriptors whose meaning is related to "Inactivation, Metabolic".

Below are MeSH descriptors whose meaning is more specific than "Inactivation, Metabolic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inactivation, Metabolic" by people in this website by year, and whether "Inactivation, Metabolic" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2008	0	1	1
2013	1	0	1
2016	0	2	2
2017	0	1	1
2020	1	0	1

Below are the most recent publications written about "Inactivation, Metabolic" by people in Profiles.

Carlisle AE, Lee N, Matthew-Onabanjo AN, Spears ME, Park SJ, Youkana D, Doshi MB, Peppers A, Li R, Joseph AB, Smith M, Simin K, Zhu LJ, Greer PL, Shaw LM, Kim D. Selenium detoxification is required for cancer-cell survival. Nat Metab. 2020 07; 2(7):603-611.

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Vallaster MP, Kukreja S, Bing XY, Ngolab J, Zhao-Shea R, Gardner PD, Tapper AR, Rando OJ. Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring. Elife. 2017 02 14; 6.

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Denby KJ, Iwig J, Bisson C, Westwood J, Rolfe MD, Sedelnikova SE, Higgins K, Maroney MJ, Baker PJ, Chivers PT, Green J. The mechanism of a formaldehyde-sensing transcriptional regulator. Sci Rep. 2016 12 09; 6:38879.

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Sun Y, Wu X, Cai X, Song M, Zheng J, Pan C, Qiu P, Zhang L, Zhou S, Tang Z, Xiao H. Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells. Mol Nutr Food Res. 2016 09; 60(9):1924-32.

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Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, B?ttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, G?mez-Lech?n MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, H?ussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzh?tter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, St?ber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. 2013 Aug; 87(8):1315-530.

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Friedmann PD, Rose JS, Swift R, Stout RL, Millman RP, Stein MD. Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial. Alcohol Clin Exp Res. 2008 Sep; 32(9):1652-60.

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Munday R, Smith BL, Munday CM. Effect of inducers of DT-diaphorase on the haemolytic activity and nephrotoxicity of 2-amino-1,4-naphthoquinone in rats. Chem Biol Interact. 2005 Aug 15; 155(3):140-7.

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Ling W, Amass L, Shoptaw S, Annon JJ, Hillhouse M, Babcock D, Brigham G, Harrer J, Reid M, Muir J, Buchan B, Orr D, Woody G, Krejci J, Ziedonis D. A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings from the National Institute on Drug Abuse Clinical Trials Network. Addiction. 2005 Aug; 100(8):1090-100.

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Sees KL, Delucchi KL, Masson C, Rosen A, Clark HW, Robillard H, Banys P, Hall SM. Methadone maintenance vs 180-day psychosocially enriched detoxification for treatment of opioid dependence: a randomized controlled trial. JAMA. 2000 Mar 08; 283(10):1303-10.

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