"Trimethoprim" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Below are MeSH descriptors whose meaning is more general than "Trimethoprim".
Below are MeSH descriptors whose meaning is more specific than "Trimethoprim".
This graph shows the total number of publications written about "Trimethoprim" by people in this website by year, and whether "Trimethoprim" was a major or minor topic of these publications.
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Below are the most recent publications written about "Trimethoprim" by people in Profiles.
Hingorani KS, Metcalf MC, Deming DT, Garman SC, Powers ET, Gierasch LM. Ligand-promoted protein folding by biased kinetic partitioning. Nat Chem Biol. 2017 04; 13(4):369-371.
Hansen C, Andrade SE, Freiman H, Dublin S, Haffenreffer K, Cooper WO, Cheetham TC, Toh S, Li DK, Raebel MA, Kuntz JL, Perrin N, Rosales AG, Carter S, Pawloski PA, Maloney EM, Graham DJ, Sahin L, Scott PE, Yap J, Davis R. Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies. Pharmacoepidemiol Drug Saf. 2016 Feb; 25(2):170-8.
Cenizal MJ, Skiest D, Luber S, Bedimo R, Davis P, Fox P, Delaney K, Hardy RD. Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2007 Jul; 51(7):2628-30.
Holdcroft CJ, Ellison RT. Trimethoprim-sulfamethoxazole reaction simulating Pneumocystis carinii pneumonia. AIDS. 1991 Aug; 5(8):1029.
Ellison RT, Judson FN, Peterson LC, Cohn DL, Ehret JM. Oral rifampin and trimethoprim/sulfamethoxazole therapy in asymptomatic carriers of methicillin-resistant Staphylococcus aureus infections. West J Med. 1984 May; 140(5):735-40.
Follansbee SE, Busch DF, Wofsy CB, Coleman DL, Gullet J, Aurigemma GP, Ross T, Hadley WK, Drew WL. An outbreak of Pneumocystis carinii pneumonia in homosexual men. Ann Intern Med. 1982 Jun; 96(6 Pt 1):705-13.