Pyrimethamine

"Pyrimethamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

Descriptor ID	D011739
MeSH Number(s)	D03.383.742.675
Concept/Terms	Pyrimethamine Pyrimethamine Malocide Malocide Tindurine Tindurine Chloridin Chloridin Daraprim Daraprim

Below are MeSH descriptors whose meaning is more general than "Pyrimethamine".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Pyrimethamine [D03.383.742.675]

Below are MeSH descriptors whose meaning is related to "Pyrimethamine".

Below are MeSH descriptors whose meaning is more specific than "Pyrimethamine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pyrimethamine" by people in this website by year, and whether "Pyrimethamine" was a major or minor topic of these publications.

Bar chart showing 16 publications over 9 distinct years, with a maximum of 4 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	1	1
2017	1	0	1
2019	0	1	1
2020	0	4	4
2021	1	1	2
2022	0	2	2
2024	2	1	3
2025	0	1	1
2026	0	1	1

Below are the most recent publications written about "Pyrimethamine" by people in Profiles.

Asua V, Niaré K, Garg S, Legac J, Tukwasibwe S, Katairo T, Bohissou FE, Crudale RM, Simkin A, Mulondo J, Nsobya SL, Ssewanyana I, Dorsey G, Bailey JA, Kamya MR, Yeka A, Rosenthal PJ, Borrmann S, Conrad MD. Multiple local PfDHFR I164L haplotype expansions drive Plasmodium falciparum antifolate resistance in Uganda. Nat Commun. 2026 Sep 04; 17(1).

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Okitwi M, Orena S, Tumwebaze PK, Katairo T, Taremwa Y, Byaruhanga O, Tukwasibwe S, Nsobya SL, Legac J, Bailey JA, Cooper RA, Conrad MD, Rosenthal PJ. Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024. Nat Commun. 2025 Aug 09; 16(1):7353.

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Juliano JJ, Giesbrecht DJ, Simkin A, Fola AA, Lyimo BM, Pereus D, Bakari C, Madebe RA, Seth MD, Mandara CI, Popkin-Hall ZR, Moshi R, Mbwambo RB, Niaré K, MacInnis B, Francis F, Mbwambo D, Garimo I, Chacky F, Aaron S, Lusasi A, Molteni F, Njau RJA, Nhiga SL, Mohamed A, Bailey JA, Ishengoma DS. Prevalence of mutations associated with artemisinin partial resistance and sulfadoxine-pyrimethamine resistance in 13 regions in Tanzania in 2021: a cross-sectional survey. Lancet Microbe. 2024 10; 5(10):100920.

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Mitchell CL, Janko MM, Verity R, Kashamuka MM, Bailey JA, Tshefu AK, Parr JB, Juliano JJ. Close Proximity to Mining Is Associated with Increased Prevalence of the Drug Resistance-Associated Mutation dhps540E in Eastern Democratic Republic of the Congo. Am J Trop Med Hyg. 2024 Aug 07; 111(2):361-364.

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Somé AF, Conrad MD, Kabré Z, Fofana A, Yerbanga RS, Bazié T, Neya C, Somé M, Kagambega TJ, Legac J, Garg S, Bailey JA, Ouédraogo J-B, Rosenthal PJ, Cooper RA. Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso. Antimicrob Agents Chemother. 2024 04 03; 68(4):e0153423.

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Dosoo DK, Bailey JA, Asante KP, Oppong FB, Niaré K, Opoku-Mensah J, Owusu-Agyei S, Greenwood B, Chandramohan D. The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of Ghana. PLoS One. 2022; 17(8):e0271489.

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Kreutzfeld O, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA, Rosenthal PJ. Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates. J Infect Dis. 2022 02 15; 225(4):696-704.

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de Araújo TE, Gomes AO, Coelho-Dos-Reis JG, Carneiro ACAV, Machado AS, Andrade GMQ, Vasconcelos-Santos DV, Januário JN, Peruhype-Magalhães V, Teixeira-Carvalho A, Vitor RWA, Antonelli LRDV, Ferro EAV, Martins-Filho OA. Long-term impact of congenital toxoplasmosis on phenotypic and functional features of circulating leukocytes from infants one year after treatment onset. Clin Immunol. 2021 11; 232:108859.

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Lozovsky ER, Daniels RF, Heffernan GD, Jacobus DP, Hartl DL. Relevance of Higher-Order Epistasis in Drug Resistance. Mol Biol Evol. 2021 01 04; 38(1):142-151.

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Myers-Hansen JL, Abuaku B, Oyebola MK, Mensah BA, Ahorlu C, Wilson MD, Awandare G, Koram KA, Ngwa AA, Ghansah A. Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana. PLoS One. 2020; 15(12):e0233478.

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