 Nicotine
"Nicotine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
| Descriptor ID |
D009538
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| MeSH Number(s) |
D03.132.760.570 D03.383.725.518
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nicotine".
Below are MeSH descriptors whose meaning is more specific than "Nicotine".
This graph shows the total number of publications written about "Nicotine" by people in this website by year, and whether "Nicotine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 0 | 3 | 3 | | 1983 | 0 | 1 | 1 | | 1986 | 2 | 0 | 2 | | 1988 | 0 | 3 | 3 | | 1990 | 1 | 2 | 3 | | 1991 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1993 | 0 | 1 | 1 | | 1994 | 1 | 1 | 2 | | 1995 | 0 | 1 | 1 | | 1997 | 2 | 1 | 3 | | 1998 | 1 | 0 | 1 | | 2000 | 3 | 0 | 3 | | 2002 | 2 | 0 | 2 | | 2003 | 3 | 0 | 3 | | 2004 | 2 | 2 | 4 | | 2005 | 3 | 2 | 5 | | 2006 | 5 | 0 | 5 | | 2007 | 5 | 2 | 7 | | 2008 | 5 | 1 | 6 | | 2010 | 1 | 4 | 5 | | 2011 | 5 | 1 | 6 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 2 | 3 | | 2014 | 4 | 1 | 5 | | 2015 | 4 | 2 | 6 | | 2016 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Nicotine" by people in Profiles.
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English TM, Smith TB, Song X, Whitman MV. Barriers to electronic cigarette use. Public Health Nurs. 2018 09; 35(5):363-368.
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Hosseinzadeh A, Thompson PR, Segal BH, Urban CF. Nicotine induces neutrophil extracellular traps. J Leukoc Biol. 2016 11; 100(5):1105-1112.
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Slater CA, Jackson A, Muldoon PP, Dawson A, O'Brien M, Soll LG, Abdullah R, Carroll FI, Tapper AR, Miles MF, Banks ML, Bettinger JC, Damaj IM. Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. Alcohol Clin Exp Res. 2016 Jan; 40(1):62-72.
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Kleinjan M, Engels RC, DiFranza JR. Parental smoke exposure and the development of nicotine craving in adolescent novice smokers: the roles of DRD2, DRD4, and OPRM1 genotypes. BMC Pulm Med. 2015; 15:115.
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Kishibe M, Griffin TM, Radek KA. Keratinocyte nicotinic acetylcholine receptor activation modulates early TLR2-mediated wound healing responses. Int Immunopharmacol. 2015 Nov; 29(1):63-70.
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Ngolab J, Liu L, Zhao-Shea R, Gao G, Gardner PD, Tapper AR. Functional Upregulation of a4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. J Neurosci. 2015 Jun 3; 35(22):8570-8.
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Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770.
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Huang W, Tam K, Fernando J, Heffernan M, King J, DiFranza JR. Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses. Nicotine Tob Res. 2015 Nov; 17(11):1311-7.
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DiFranza JR. A 2015 Update on The Natural History and Diagnosis of Nicotine Addiction. Curr Pediatr Rev. 2015; 11(1):43-55.
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Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci. 2014 Dec; 17(12):1751-8.
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