 Receptor, Epidermal Growth Factor
"Receptor, Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
| Descriptor ID |
D011958
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.100 D12.776.543.750.060.249 D12.776.543.750.750.360.300 D12.776.543.750.750.400.340
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| Concept/Terms |
Receptor, Epidermal Growth Factor- Receptor, Epidermal Growth Factor
- EGF Receptor
- Epidermal Growth Factor Receptor
- Epidermal Growth Factor Receptor Kinase
- Epidermal Growth Factor Receptor Protein-Tyrosine Kinase
- Epidermal Growth Factor Receptor Protein Tyrosine Kinase
- erbB-1 Proto-Oncogene Protein
- Proto-Oncogene Protein, erbB-1
- erbB 1 Proto Oncogene Protein
- Receptor, EGF
- Receptor, TGF-alpha
- Receptor, TGF alpha
- Receptor, Transforming-Growth Factor alpha
- Receptor, Transforming Growth Factor alpha
- Receptor, Urogastrone
- Receptors, Epidermal Growth Factor
- Receptors, Epidermal Growth Factor-Urogastrone
- Receptors, Epidermal Growth Factor Urogastrone
- TGF-alpha Receptor
- Transforming Growth Factor alpha Receptor
- Urogastrone Receptor
- c-erbB-1 Protein
- c erbB 1 Protein
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Below are MeSH descriptors whose meaning is more general than "Receptor, Epidermal Growth Factor".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
- Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
- Receptor, Epidermal Growth Factor [D08.811.913.696.620.682.725.400.100]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptor Protein-Tyrosine Kinases [D12.776.543.750.060]
- Receptor, Epidermal Growth Factor [D12.776.543.750.060.249]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Gastrointestinal Hormone [D12.776.543.750.750.360]
- Receptor, Epidermal Growth Factor [D12.776.543.750.750.360.300]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptor, Epidermal Growth Factor [D12.776.543.750.750.400.340]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Epidermal Growth Factor".
This graph shows the total number of publications written about "Receptor, Epidermal Growth Factor" by people in this website by year, and whether "Receptor, Epidermal Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 2 | 1 | 3 | | 1990 | 2 | 0 | 2 | | 1991 | 1 | 0 | 1 | | 1994 | 3 | 0 | 3 | | 1995 | 1 | 1 | 2 | | 1997 | 2 | 1 | 3 | | 1999 | 1 | 2 | 3 | | 2001 | 1 | 0 | 1 | | 2002 | 0 | 3 | 3 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 2 | 4 | | 2005 | 3 | 3 | 6 | | 2007 | 3 | 1 | 4 | | 2008 | 2 | 2 | 4 | | 2009 | 1 | 1 | 2 | | 2010 | 3 | 3 | 6 | | 2011 | 2 | 2 | 4 | | 2012 | 3 | 2 | 5 | | 2013 | 4 | 1 | 5 | | 2014 | 5 | 3 | 8 | | 2016 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Epidermal Growth Factor" by people in Profiles.
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Zhang XD, Baladandayuthapani V, Lin H, Mulligan G, Li B, Esseltine DW, Qi L, Xu J, Hunziker W, Barlogie B, Usmani SZ, Zhang Q, Crowley J, Hoering A, Shah JJ, Weber DM, Manasanch EE, Thomas SK, Li BZ, Wang HH, Zhang J, Kuiatse I, Tang JL, Wang H, He J, Yang J, Milan E, Cenci S, Ma WC, Wang ZQ, Davis RE, Yang L, Orlowski RZ. Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling. Cancer Cell. 2016 05 09; 29(5):639-652.
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Patel AL, Chen X, Wood ST, Stuart ES, Arcaro KF, Molina DP, Petrovic S, Furdui CM, Tsang AW. Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development. BMC Microbiol. 2014 Dec 04; 14:277.
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Rosenblum F, Hutchinson LM, Garver J, Woda B, Cosar E, Kurian EM. Cytology specimens offer an effective alternative to formalin-fixed tissue as demonstrated by novel automated detection for ALK break-apart FISH testing and immunohistochemistry in lung adenocarcinoma. Cancer Cytopathol. 2014 Nov; 122(11):810-21.
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Lindberg JM, Newhook TE, Adair SJ, Walters DM, Kim AJ, Stelow EB, Parsons JT, Bauer TW. Co-treatment with panitumumab and trastuzumab augments response to the MEK inhibitor trametinib in a patient-derived xenograft model of pancreatic cancer. Neoplasia. 2014 Jul; 16(7):562-71.
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Hosur V, Johnson KR, Burzenski LM, Stearns TM, Maser RS, Shultz LD. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2200-9.
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Qin Y, Liu XJ, Li L, Liu XJ, Li Y, Gao RJ, Shao RG, Zhen YS. MMP-2/9-oriented combinations enhance antitumor efficacy of EGFR/HER2-targeting fusion proteins and gemcitabine. Oncol Rep. 2014 Jul; 32(1):121-30.
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Peterson JL, Phelps ED, Doll MA, Schaal S, Ceresa BP. The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis. Invest Ophthalmol Vis Sci. 2014 May 01; 55(5):2870-80.
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Wang X, Beitler JJ, Wang H, Lee MJ, Huang W, Koenig L, Nannapaneni S, Amin AR, Bonner M, Shin HJ, Chen ZG, Arbiser JL, Shin DM. Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis. PLoS One. 2014; 9(2):e86369.
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Fan Y, Wang S, Hernandez J, Yenigun VB, Hertlein G, Fogarty CE, Lindblad JL, Bergmann A. Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila. PLoS Genet. 2014 Jan; 10(1):e1004131.
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Shazeeb MS, Gupta S, Bogdanov A. MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model. Mol Imaging Biol. 2013 Dec; 15(6):675-84.
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