Multiple Endocrine Neoplasia Type 1

"Multiple Endocrine Neoplasia Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

Descriptor ID	D018761
MeSH Number(s)	C04.588.322.400.500 C04.651.600.500 C04.700.630.500 C16.320.700.630.500 C19.344.400.500
Concept/Terms	Multiple Endocrine Neoplasia Type 1 Multiple Endocrine Neoplasia Type 1 Multiple Endocrine Neoplasia Type I Neoplasms, Multiple Endocrine Type I Multiple Endocrine Neoplasms Type 1 Neoplasia, Multiple Endocrine Type 1 Neoplasms, Multiple Endocrine Type 1 Wermer Syndrome

Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 1".

Diseases [C]
Neoplasms [C04]
Neoplasms by Site [C04.588]
Endocrine Gland Neoplasms [C04.588.322]
Multiple Endocrine Neoplasia [C04.588.322.400]
Multiple Endocrine Neoplasia Type 1 [C04.588.322.400.500]
Neoplasms, Multiple Primary [C04.651]
Multiple Endocrine Neoplasia [C04.651.600]
Multiple Endocrine Neoplasia Type 1 [C04.651.600.500]
Neoplastic Syndromes, Hereditary [C04.700]
Multiple Endocrine Neoplasia [C04.700.630]
Multiple Endocrine Neoplasia Type 1 [C04.700.630.500]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Neoplastic Syndromes, Hereditary [C16.320.700]
Multiple Endocrine Neoplasia [C16.320.700.630]
Multiple Endocrine Neoplasia Type 1 [C16.320.700.630.500]
Endocrine System Diseases [C19]
Endocrine Gland Neoplasms [C19.344]
Multiple Endocrine Neoplasia [C19.344.400]
Multiple Endocrine Neoplasia Type 1 [C19.344.400.500]

Below are MeSH descriptors whose meaning is related to "Multiple Endocrine Neoplasia Type 1".

Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 1" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 1" was a major or minor topic of these publications.

Bar chart showing 7 publications over 4 distinct years, with a maximum of 3 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
2016	2	1	3
2017	0	1	1
2022	1	1	2

Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 1" by people in Profiles.

Cheng Z, Guo D, Ruzi A, Pan T, You K, Chen Y, Huang X, Zhang J, Yang F, Niu L, Xu K, Li YX. Modeling MEN1 with Patient-Origin iPSCs Reveals GLP-1R Mediated Hypersecretion of Insulin. Cells. 2022 08 03; 11(15).

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Seabrook A, Wijewardene A, De Sousa S, Wong T, Sheriff N, Gill AJ, Iyer R, Field M, Luxford C, Clifton-Bligh R, McCormack A, Tucker K. MEN4, the MEN1 Mimicker: A Case Series of three Phenotypically Heterogenous Patients With Unique CDKN1B Mutations. J Clin Endocrinol Metab. 2022 07 14; 107(8):2339-2349.

View in: PubMed
Liu H, Guo D, Ruzi A, Chen Y, Pan T, Yang F, Li J, Xu K, Zhou T, Qin D, Li YX. Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells. PLoS One. 2017; 12(6):e0179353.

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Guo D, Wu F, Liu H, Gao G, Kou S, Yang F, Abbas N, Zhou T, Cai X, Zhang H, Qin D, Li J, Xu K, Li YX. Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome. Stem Cell Res. 2017 01; 18:64-66.

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Guo D, Liu H, Gao G, Liu Y, Zhuang Y, Yang F, Wang K, Zhou T, Qin D, Hong L, Li J, Xu K, Li YX. Creating a patient carried Men1 gene point mutation on wild type iPSCs locus mediated by CRISPR/Cas9 and ssODN. Stem Cell Res. 2017 01; 18:67-69.

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Guo D, Wu F, Liu H, Gao G, Kou S, Yang F, Abbas N, Zhou T, Cai X, Zhang H, Qin D, Li J, Xu K, Li YX. Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome. Stem Cell Res. 2017 01; 18:70-72.

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Lambert LA, Shapiro SE, Lee JE, Perrier ND, Truong M, Wallace MJ, Hoff AO, Gagel RF, Evans DB. Surgical treatment of hyperparathyroidism in patients with multiple endocrine neoplasia type 1. Arch Surg. 2005 Apr; 140(4):374-82.

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Stock JL, Warth MR, Teh BT, Coderre JA, Overdorf JH, Baumann G, Hintz RL, Hartman ML, Seizinger BR, Larsson C, Aronin N. A kindred with a variant of multiple endocrine neoplasia type 1 demonstrating frequent expression of pituitary tumors but not linked to the multiple endocrine neoplasia type 1 locus at chromosome region 11q13. J Clin Endocrinol Metab. 1997 Feb; 82(2):486-92.

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