Complement C4b-Binding Protein

"Complement C4b-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serum protein that regulates the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. It binds as a cofactor to COMPLEMENT FACTOR I which then hydrolyzes the COMPLEMENT C4B in the CLASSICAL PATHWAY C3 CONVERTASE (C4bC2a).

Descriptor ID	D050716
MeSH Number(s)	D12.776.124.486.274.920.662
Concept/Terms	Complement C4b-Binding Protein Complement C4b-Binding Protein C4b-Binding Protein, Complement Complement C4b Binding Protein Protein, Complement C4b-Binding C4b-C3b Inactivator Cofactor C4b C3b Inactivator Cofactor Cofactor, C4b-C3b Inactivator C4bC3bINA-Cofactor C4bC3bINA Cofactor Complement C3b-C4b Inactivator Cofactor Complement C3b C4b Inactivator Cofactor Complement Component 4b-Binding Protein Complement Component 4b Binding Protein C4b-Binding Protein C4b Binding Protein Protein, C4b-Binding Complement 4b Binding Protein

Below are MeSH descriptors whose meaning is more general than "Complement C4b-Binding Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement Inactivator Proteins [D12.776.124.486.274.920]
Complement C4b-Binding Protein [D12.776.124.486.274.920.662]

Below are MeSH descriptors whose meaning is related to "Complement C4b-Binding Protein".

Below are MeSH descriptors whose meaning is more specific than "Complement C4b-Binding Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C4b-Binding Protein" by people in this website by year, and whether "Complement C4b-Binding Protein" was a major or minor topic of these publications.

Bar chart showing 17 publications over 10 distinct years, with a maximum of 3 publications in 2008 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	1	2
2007	2	0	2
2008	2	1	3
2012	0	2	2
2013	0	1	1
2018	0	1	1
2019	2	1	3
2020	1	0	1
2021	1	0	1
2026	1	0	1

Below are the most recent publications written about "Complement C4b-Binding Protein" by people in Profiles.

Broden MW, Shaughnessy J, Mohlin F, Cardenas AJ, Blom AM, Ram S, Criss AK. C4BP occludes the non-opsonic interaction of Neisseria gonorrhoeae with human neutrophil CEACAMs. Infect Immun. 2026 Jul 14; 94(7):e0017626.

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Bettoni S, Maziarz K, Stone MRL, Blaskovich MAT, Potempa J, Bazzo ML, Unemo M, Ram S, Blom AM. Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae. Front Immunol. 2021; 12:726801.

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Laabei M, Colineau L, Bettoni S, Maziarz K, Ermert D, Riesbeck K, Ram S, Blom AM. Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing. Front Immunol. 2020; 11:2122.

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Bettoni S, Shaughnessy J, Maziarz K, Ermert D, Gulati S, Zheng B, M?rgelin M, Jacobsson S, Riesbeck K, Unemo M, Ram S, Blom AM. C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections. JCI Insight. 2019 12 05; 4(23).

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Gulati S, Beurskens FJ, de Kreuk BJ, Roza M, Zheng B, DeOliveira RB, Shaughnessy J, Nowak NA, Taylor RP, Botto M, He X, Ingalls RR, Woodruff TM, Song WC, Schuurman J, Rice PA, Ram S. Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody. PLoS Biol. 2019 06; 17(6):e3000323.

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Ermert D, Laabei M, Weckel A, M?rgelin M, Lundqvist M, Bj?rck L, Ram S, Linse S, Blom AM. The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus. Front Immunol. 2019; 10:1230.

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Ermert D, Weckel A, Magda M, M?rgelin M, Shaughnessy J, Rice PA, Bj?rck L, Ram S, Blom AM. Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion. J Immunol. 2018 05 15; 200(10):3495-3505.

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Lewis LA, Ram S. Meningococcal disease and the complement system. Virulence. 2014 Jan 01; 5(1):98-126.

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Lewis LA, Shafer WM, Dutta Ray T, Ram S, Rice PA. Phosphoethanolamine residues on the lipid A moiety of Neisseria gonorrhoeae lipooligosaccharide modulate binding of complement inhibitors and resistance to complement killing. Infect Immun. 2013 Jan; 81(1):33-42.

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Gulati S, Agarwal S, Vasudhev S, Rice PA, Ram S. Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein. J Immunol. 2012 Apr 01; 188(7):3416-25.

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