Ornithine

"Ornithine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An amino acid produced in the urea cycle by the splitting off of urea from arginine.

Descriptor ID	D009952
MeSH Number(s)	D12.125.068.665 D12.125.095.765
Concept/Terms	Ornithine Ornithine Ornithine, (L)-Isomer 2,5-Diaminopentanoic Acid 2,5 Diaminopentanoic Acid Ornithine Hydrochloride, (D)-Isomer Ornithine Hydrochloride, (D)-Isomer Ornithine Hydrochloride, (DL)-Isomer Ornithine Hydrochloride, (DL)-Isomer Ornithine Hydrochloride, (L)-Isomer Ornithine Hydrochloride, (L)-Isomer Ornithine Monoacetate, (L)-Isomer Ornithine Monoacetate, (L)-Isomer Ornithine, (DL)-Isomer Ornithine, (DL)-Isomer Ornithine Monohydrochloride, (D)-Isomer Ornithine Monohydrochloride, (D)-Isomer Ornithine Monohydrochloride, (DL)-Isomer Ornithine Monohydrochloride, (DL)-Isomer Ornithine Phosphate (1:1), (L)-Isomer Ornithine Phosphate (1:1), (L)-Isomer Ornithine Sulfate (1:1), (L)-Isomer Ornithine Sulfate (1:1), (L)-Isomer Ornithine, (D)-Isomer Ornithine, (D)-Isomer Ornithine Dihydrochloride, (L)-Isomer Ornithine Dihydrochloride, (L)-Isomer Ornithine Monohydrobromide, (L)-Isomer Ornithine Monohydrobromide, (L)-Isomer

Below are MeSH descriptors whose meaning is more general than "Ornithine".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Basic [D12.125.068]
Ornithine [D12.125.068.665]
Amino Acids, Diamino [D12.125.095]
Ornithine [D12.125.095.765]

Below are MeSH descriptors whose meaning is related to "Ornithine".

Below are MeSH descriptors whose meaning is more specific than "Ornithine".

Ornithine
Eflornithine

publications

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This graph shows the total number of publications written about "Ornithine" by people in this website by year, and whether "Ornithine" was a major or minor topic of these publications.

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Below are the most recent publications written about "Ornithine" by people in Profiles.

Kawalkowska J, Quirke AM, Ghari F, Davis S, Subramanian V, Thompson PR, Williams RO, Fischer R, La Thangue NB, Venables PJ. Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses. Sci Rep. 2016 05 23; 6:26430.

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Horibata S, Vo TV, Subramanian V, Thompson PR, Coonrod SA. Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells. J Vis Exp. 2015 May 20; (99):e52727.

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Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ. Inhibiting protein arginine deiminases has antioxidant consequences. J Pharmacol Exp Ther. 2015 Apr; 353(1):64-70.

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Lange S, Rocha-Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M, Raivich G. Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates. J Neurochem. 2014 Aug; 130(4):555-62.

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Knight JS, Luo W, O'Dell AA, Yalavarthi S, Zhao W, Subramanian V, Guo C, Grenn RC, Thompson PR, Eitzman DT, Kaplan MJ. Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circ Res. 2014 Mar 14; 114(6):947-56.

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Knight JS, Zhao W, Luo W, Subramanian V, O'Dell AA, Yalavarthi S, Hodgin JB, Eitzman DT, Thompson PR, Kaplan MJ. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J Clin Invest. 2013 Jul; 123(7):2981-93.

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Kan R, Jin M, Subramanian V, Causey CP, Thompson PR, Coonrod SA. Potential role for PADI-mediated histone citrullination in preimplantation development. BMC Dev Biol. 2012 Jun 19; 12:19.

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Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol. 2012 Jan 20; 7(1):160-5.

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Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem. 2011 Oct 13; 54(19):6919-35.

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