"Epoprostenol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
| Descriptor ID |
D011464
|
| MeSH Number(s) |
D10.251.355.255.550.550.500 D23.469.050.175.725.550.500
|
| Concept/Terms |
Epoprostenol- Epoprostenol
- PGI2
- Prostaglandin I2
- Prostacyclin
- Prostaglandin I(2)
- Epoprostanol
- PGX
Epoprostenol Sodium- Epoprostenol Sodium
- Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer
|
Below are MeSH descriptors whose meaning is more general than "Epoprostenol".
Below are MeSH descriptors whose meaning is more specific than "Epoprostenol".
This graph shows the total number of publications written about "Epoprostenol" by people in this website by year, and whether "Epoprostenol" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Epoprostenol" by people in Profiles.
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Ling QL, Akasaka H, Chen C, Haile CN, Winoske K, Ruan KH. The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus. J Neuroimmune Pharmacol. 2020 06; 15(2):292-308.
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Ling QL, Murdoch E, Ruan KH. How can we address the controversies surrounding the use of NSAIDS in neurodegeneration? Future Med Chem. 2016 07; 8(11):1153-5.
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Daley JT, Brown ML, Watkins T, Traish AM, Huang YH, Moreland RB, De Tejada IS. Prostanoid production in rabbit corpus cavernosum: I. regulation by oxygen tension. J Urol. 1996 Apr; 155(4):1482-7.
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Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD. Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. J Clin Invest. 1996 Feb 15; 97(4):979-87.
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Weber C, Kruse HJ, Sellmayer A, Erl W, Weber PC. Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. Biochem Biophys Res Commun. 1993 Sep 15; 195(2):874-80.
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Siess W, Boehlig B, Weber PC, Lapetina EG. Prostaglandin endoperoxide analogues stimulate phospholipase C and protein phosphorylation during platelet shape change. Blood. 1985 May; 65(5):1141-8.