Cell Degranulation

"Cell Degranulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.

Descriptor ID	D015550
MeSH Number(s)	G04.468.160
Concept/Terms	Cell Degranulation Cell Degranulation Degranulation, Cell

Below are MeSH descriptors whose meaning is more general than "Cell Degranulation".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Exocytosis [G04.468]
Cell Degranulation [G04.468.160]

Below are MeSH descriptors whose meaning is related to "Cell Degranulation".

Below are MeSH descriptors whose meaning is more specific than "Cell Degranulation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cell Degranulation" by people in this website by year, and whether "Cell Degranulation" was a major or minor topic of these publications.

Bar chart showing 17 publications over 13 distinct years, with a maximum of 3 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
2005	1	2	3
2010	0	2	2
2012	0	1	1
2014	0	1	1
2016	1	0	1
2017	0	1	1
2018	0	2	2
2020	0	1	1
2021	0	1	1
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "Cell Degranulation" by people in Profiles.

Ranjitkar S, Krajewski D, Garcia C, Tedeschi C, Polukort SH, Rovatti J, Mire M, Blesso CN, Jellison E, Schneider SS, Ryan JJ, Mathias CB. IL-10 Differentially Promotes Mast Cell Responsiveness to IL-33, Resulting in Enhancement of Type 2 Inflammation and Suppression of Neutrophilia. J Immunol. 2024 May 01; 212(9):1407-1419.

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Mielke D, Stanfield-Oakley S, Jha S, Keyes T, Zalaquett A, Dunn B, Rodgers N, Oguin T, Sempowski GD, Binder RA, Gray GC, Karuna S, Corey L, Hural J, Tomaras GD, Pollara J, Ferrari G. Development of flow cytometry-based assays to assess the ability of antibodies to bind to SARS-CoV-2-infected and spike-transfected cells and mediate NK cell degranulation. Cytometry A. 2022 06; 101(6):483-496.

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Harcha PA, Garc?s P, Arredondo C, Fern?ndez G, S?ez JC, van Zundert B. Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions. Int J Mol Sci. 2021 Feb 15; 22(4).

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Krajewski D, Polukort SH, Gelzinis J, Rovatti J, Kaczenski E, Galinski C, Pantos M, Shah NN, Schneider SS, Kennedy DR, Mathias CB. Protein Disulfide Isomerases Regulate IgE-Mediated Mast Cell Responses and Their Inhibition Confers Protective Effects During Food Allergy. Front Immunol. 2020; 11:606837.

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Pulsifer AR, Vashishta A, Reeves SA, Wolfe JK, Palace SG, Proulx MK, Goguen J, Bodduluri SR, Haribabu B, Uriarte SM, Lawrenz MB. Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function Approach. Infect Immun. 2020 02 20; 88(3).

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Rodr?guez-Alc?zar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenm?ller W, Latz E, Franklin BS. Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1? Inflammation in Human Macrophages. J Immunol. 2019 01 15; 202(2):550-558.

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Krajewski D, Kaczenski E, Rovatti J, Polukort S, Thompson C, Dollard C, Ser-Dolansky J, Schneider SS, Kinney SRM, Mathias CB. Epigenetic Regulation via Altered Histone Acetylation Results in Suppression of Mast Cell Function and Mast Cell-Mediated Food Allergic Responses. Front Immunol. 2018; 9:2414.

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Martin RK, Damle SR, Valentine YA, Zellner MP, James BN, Lownik JC, Luker AJ, Davis EH, DeMeules MM, Khandjian LM, Finkelman FD, Urban JF, Conrad DH. B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade. Cell Rep. 2018 02 13; 22(7):1824-1834.

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Ries M, Reynolds MR, Bashkueva K, Crosno K, Capuano S, Prall TM, Wiseman R, O'Connor DH, Rakasz EG, Uno H, Lifson JD, Evans DT. KIR3DL01 upregulation on gut natural killer cells in response to SIV infection of KIR- and MHC class I-defined rhesus macaques. PLoS Pathog. 2017 Jul; 13(7):e1006506.

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Bhutto IA, McLeod DS, Jing T, Sunness JS, Seddon JM, Lutty GA. Increased choroidal mast cells and their degranulation in age-related macular degeneration. Br J Ophthalmol. 2016 May; 100(5):720-6.

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