"Dantrolene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
| Descriptor ID |
D003620
|
| MeSH Number(s) |
D03.383.129.308.432.555.287
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dantrolene".
Below are MeSH descriptors whose meaning is more specific than "Dantrolene".
This graph shows the total number of publications written about "Dantrolene" by people in this website by year, and whether "Dantrolene" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dantrolene" by people in Profiles.
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Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, Umezawa A, Greer PA, Urano F. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):E5292-301.
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Muehlschlegel S, Carandang R, Hall W, Kini N, Izzy S, Garland B, Ouillette C, van der Bom IM, Flood TF, Gounis MJ, Weaver JP, Barton B, Wakhloo AK. Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial. J Neurol Neurosurg Psychiatry. 2015 Sep; 86(9):1029-35.
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Muehlschlegel S, Rordorf G, Sims J. Effects of a single dose of dantrolene in patients with cerebral vasospasm after subarachnoid hemorrhage: a prospective pilot study. Stroke. 2011 May; 42(5):1301-6.
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Muehlschlegel S, Rordorf G, Bodock M, Sims JR. Dantrolene mediates vasorelaxation in cerebral vasoconstriction: a case series. Neurocrit Care. 2009; 10(1):116-21.
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Muehlschlegel S, Sims JR. Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit. Neurocrit Care. 2009; 10(1):103-15.
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Charles AC, Dirksen ER, Merrill JE, Sanderson MJ. Mechanisms of intercellular calcium signaling in glial cells studied with dantrolene and thapsigargin. Glia. 1993 Feb; 7(2):134-45.
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Bowers W, Daum P, Blaha M, Stevens C, Castro I, Leav I. Calcium antagonists and heat-induced hepatic injury. Virchows Arch B Cell Pathol Incl Mol Pathol. 1987; 53(4):235-42.