"Phenytoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
| Descriptor ID |
D010672
|
| MeSH Number(s) |
D03.383.129.308.432.555.730
|
| Concept/Terms |
Phenytoin- Phenytoin
- 5,5-Diphenylhydantoin
- Fenitoin
- 5,5-diphenylimidazolidine-2,4-dione
- Diphenylhydantoin
Phenytoin Sodium- Phenytoin Sodium
- Sodium Diphenylhydantoinate
- Diphenylhydantoinate, Sodium
|
Below are MeSH descriptors whose meaning is more general than "Phenytoin".
Below are MeSH descriptors whose meaning is more specific than "Phenytoin".
This graph shows the total number of publications written about "Phenytoin" by people in this website by year, and whether "Phenytoin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Phenytoin" by people in Profiles.
-
Holmes LB, Hunt AT, Will LA, Dhillon R, Deutsch C, Adams J. Facial dysmorphology in children exposed in pregnancy to anticonvulsant medications correlates with deficits in IQ. Am J Med Genet A. 2024 04; 194(4):e63511.
-
Walker A, Rupal A, Jani C, Al Omari O, Singh H, Patel D, Perrino C, McCannon J. Longstanding Phenytoin Use as a Cause of Progressive Dyspnea. Chest. 2022 02; 161(2):e91-e96.
-
Alix V, James M, Jackson AH, Visintainer PF, Singh R. Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital. J Child Neurol. 2021 01; 36(1):30-37.
-
McCune JS, Wang T, Bo-Subait K, Aljurf M, Beitinjaneh A, Bubalo J, Cahn JY, Cerny J, Chhabra S, Cumpston A, Dupuis LL, Lazarus HM, Marks DI, Maziarz RT, Norkin M, Prestidge T, Mineishi S, Krem MM, Pasquini M, Martin PJ. Association of Antiepileptic Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning. Biol Blood Marrow Transplant. 2019 07; 25(7):1424-1431.
-
Gleeson TP, Griswold MK, Broach J, Babu KM. What is This Rash? J Med Toxicol. 2016 06; 12(2):199-200.
-
Sonis J, Borczuk P, Ptak T, Miller ES. Seizure and Fever. J Emerg Med. 2016 May; 50(5):773-7.
-
Orup HI, Deutsch CK, Holmes LB. Laser light scan analysis of the "anticonvulsant face". Birth Defects Res A Clin Mol Teratol. 2014 Dec; 100(12):905-11.
-
Burns JM, Marino A, Manno M, Rhyee S, Boyer EW. Status epilepticus in a child secondary to ingestion of skin-lightening cream. Pediatr Emerg Care. 2013 May; 29(5):662-4.
-
Yu W, Calos M, Pilitsis J, Shin DS. Deconstructing the neural and ionic involvement of seizure-like events in the striatal network. Neurobiol Dis. 2013 Apr; 52:128-36.
-
VanCott AC, Cramer JA, Copeland LA, Zeber JE, Steinman MA, Dersh JJ, Glickman ME, Mortensen EM, Amuan ME, Pugh MJ. Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system. BMC Med. 2010 Jan 11; 8:4.