"Complement C2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Descriptor ID |
D003175
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MeSH Number(s) |
D12.776.124.486.274.150
|
Concept/Terms |
Complement C2- Complement C2
- C2, Complement
- Complement 2
- Complement Component 2
- Component 2, Complement
- C2 Complement
- Complement, C2
|
Below are MeSH descriptors whose meaning is more general than "Complement C2".
Below are MeSH descriptors whose meaning is more specific than "Complement C2".
This graph shows the total number of publications written about "Complement C2" by people in this website by year, and whether "Complement C2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 0 | 1 | 1 |
2008 | 0 | 2 | 2 |
2009 | 0 | 1 | 1 |
2012 | 1 | 0 | 1 |
2013 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C2" by people in Profiles.
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Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997.
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Merle BM, Silver RE, Rosner B, Seddon JM. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016 Apr; 103(4):1135-44.
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Seddon JM, Reynolds R, Yu Y, Rosner B. Validation of a prediction algorithm for progression to advanced macular degeneration subtypes. JAMA Ophthalmol. 2013 Apr; 131(4):448-55.
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Thakkinstian A, McEvoy M, Chakravarthy U, Chakrabarti S, McKay GJ, Ryu E, Silvestri G, Kaur I, Francis P, Iwata T, Akahori M, Arning A, Edwards AO, Seddon JM, Attia J. The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis. Am J Epidemiol. 2012 Sep 01; 176(5):361-72.
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Reynolds R, Hartnett ME, Atkinson JP, Giclas PC, Rosner B, Seddon JM. Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5818-27.
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Seddon JM, Reynolds R, Maller J, Fagerness JA, Daly MJ, Rosner B. Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2044-53.
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Seddon JM, Reynolds R, Rosner B. Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):586-91.
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Montezuma SR, Sobrin L, Seddon JM. Review of genetics in age related macular degeneration. Semin Ophthalmol. 2007 Oct-Dec; 22(4):229-40.